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Macrolide lactams

Compounds that are analog of macrolides that contain lactam rings in place of lactone rings; they are a class of antibiotics. Lactam rings are nitrogen analogs of lactone rings.

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1

Research Products International Corp FK-506, 25 MG
SDP

Substance Name: [Tacrolimus] [Fujimycin]
CAS Number: 104987-11-3
Molecular Formula: C44H69NO12
Molecular Weight: 804.0

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2

Medchemexpress LLC Tacrolimus monohydrate | 109581-93-3 | MFCD11045918 | 99.9% | 822.03 g·mol⁻¹ | C44H71NO13 | 5 MG
SDP

Tacrolimus monohydrate is a macrocyclic lactone immunosuppressant reagent that binds FK506 binding protein (FKBP) and inhibits calcineurin phosphatase, suppressing T-cell signaling and IL-2 transcription for in vitro immunology and biochemical studies.

  • High purity suitable for research applications.
  • Molecular formula C44H71NO13; molecular weight 822.03 g·mol⁻¹.
  • CAS number 109581-93-3 for unambiguous identification.
  • Store protected from light at 4°C; in solution store at -80°C for long-term stability.
  • Commonly used in assays targeting calcineurin and FKBP-mediated pathways.

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3

Medchemexpress LLC (+)-(R)-[(E)-3-(2-phenylpyrazolo[1,5-a]pyridin-3-yl)acryloyl]-2-piperidineethanol | 121524-18-3 | 99.2% | 375.46 | C23H25N3O2 | 50 MG
SDP

FK 453 is a non-xanthine adenosine A1 receptor antagonist (compound 1d) used in pharmacological research. It is reported as potent and selective, with an IC50 of 17.2 nM. The compound has chemical formula C23H25N3O2, molecular weight 375.46, and reported purity 99.20%.

  • Potent and selective A1 receptor antagonist (IC50 17.2 nM).
  • High reported purity suitable for research use (99.2%).
  • Chemical formula C23H25N3O2 and molecular weight 375.46.
  • Available in small research quantities, for example 50 mg.
  • Supplied with supporting analytical data such as COA, HPLC, and LCMS.

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4

Medchemexpress LLC (E)-1-[(2R)-2-(2-hydroxyethyl)piperidin-1-yl]-3-(2-phenylpyrazolo[1,5-a]pyridin-3-yl)prop-2-en-1-one | 121524-18-3 | 99.2% | 375.46 g/mol | C23H25N3O2 | 1 MG
SDP

FK 453 is a research-grade small molecule adenosine A1 receptor antagonist with low-nanomolar potency (IC50 = 17.2 nM). It is supplied as a high-purity powder intended for in vitro pharmacology, receptor profiling, and other laboratory research applications.

  • Potent and selective adenosine A1 receptor antagonist.
  • Low-nanomolar potency (IC50 17.2 nM).
  • High purity (99.2%).
  • Molecular formula C23H25N3O2; molecular weight 375.46 g/mol.
  • Supplied as a powder with DMSO solubility for assay preparation.
  • Available in small-scale quantities suitable for research use.

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5

Medchemexpress LLC E/Z-FK-506 26,28-allylic ester rearrangement impurity | 131944-48-4 | >90.0% | 804.02 | C44H69NO12 | 10 MG
SDP

(E/Z)-FK-506 26,28-allylic ester rearrangement impurity (FK506-A) is an impurity of tacrolimus used as a reference standard for analytical and stability studies. It is intended for research and analytical applications to identify, quantify, and qualify impurity profiles; consult the certificate of analysis for storage and handling details.

  • Reference impurity of tacrolimus for analytical method development.
  • Suitable for impurity identification, reporting, and qualification studies.
  • High-purity material for reliable chromatographic and mass spectrometric analysis (>90.0%).
  • Supplied as a solid for laboratory use; consult the certificate of analysis for storage instructions.
  • Molecular formula C44H69NO12 and molecular weight 804.02 for compound identification.

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6

Medchemexpress LLC FK 453 | 121524-18-3 | 99.2% | 375.46 | C23H25N3O2 | 25 MG
SDP

FK 453 is a research-use adenosine A1 receptor antagonist (compound 1d) characterized by potent activity and a defined chemical profile. It exhibits an IC50 of 17.2 nM and is supplied as a high-purity powder with recommended storage conditions for both powder and solution forms.

  • Potent, selective adenosine A1 receptor antagonist (IC50 = 17.2 nM).
  • High purity: 99.2%.
  • Molecular formula C23H25N3O2 and molecular weight 375.46.
  • Available in multiple small-scale package sizes, including 25 mg.
  • Storage recommended as powder at -20°C (3 years) or 4°C (2 years).
  • In solvent storage guidance: -80°C (6 months) or -20°C (1 month).
  • For research use only; not for human or clinical use.

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7

Medchemexpress LLC Fk 453 (compound 1d) | 121524-18-3 | 99.2% | 375.46 g·mol⁻¹ | C23H25N3O2 | 5 MG
SDP

FK 453 (compound 1d) is a potent and selective adenosine A1 receptor antagonist (IC50 17.2 nM) intended for research use. It is a non-xanthine small molecule used in pharmacological studies to probe A1 receptor function and ligand interactions.

  • Potent adenosine A1 antagonist (IC50 17.2 nM).
  • High purity 99.2%.
  • Molecular weight 375.46 g·mol⁻¹.
  • Chemical formula C23H25N3O2.
  • Supplied as 5 mg solid for laboratory research.
  • Suitable for in vitro pharmacology and receptor binding assays.

ENCOMPASS_PREFERRED
8

Medchemexpress LLC (E/Z)-FK-506 26,28-allylic ester rearrangement impurity | 131944-48-4 | 804.02 | C44H69NO12 | 5 MG
SDP

(E/Z)-FK-506 26,28-allylic ester rearrangement impurity (FK506-A) is an impurity of tacrolimus supplied as a reference substance for analytical and research applications. It is intended for use in impurity identification, method development, and stability studies where characterization of tacrolimus-related degradation or synthesis by-products is required.

  • Provides a characterized impurity reference for analytical validation.
  • Enables impurity profiling and stability testing of tacrolimus samples.
  • Compatible with HPLC and LC-MS analytical workflows.
  • Offered in small milligram quantities suitable for method development.
  • Includes CAS and molecular data to support documentation.

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9

Medchemexpress LLC Tacrolimus | 104987-11-3 | MFCD00869853 | >98.0% | 804.02 | C44H69NO12 | 5 MG
SDP

Tacrolimus is a macrolide immunosuppressant (FK506) used in research to inhibit calcineurin-dependent T-cell activation. It binds FK506-binding protein to form a complex that inhibits calcineurin phosphatase, reducing IL-2 transcription and downstream immune responses. Supplied as a high-purity analytical standard for research and analytical applications.

  • Inhibits calcineurin-dependent T-cell activation.
  • Binds FK506-binding proteins to form an inhibitory complex.
  • High purity (>98%) suitable for analytical work.
  • Molecular weight 804.02, formula C44H69NO12.
  • Useful for immunology and signal transduction studies.
  • Provided in small research quantities appropriate for assays.

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10

Medchemexpress LLC Fk-453 | 121524-18-3 | 99.2% | 375.46 g·mol⁻¹ | C23H25N3O2 | 100 MG
SDP

FK 453 is a potent, selective adenosine A1 receptor antagonist (IC50 = 17.2 nM) supplied as a high-purity small-molecule powder for research use. It includes recommended storage and solvent handling guidance to support reproducible in vitro assays.

  • High purity 99.2%.
  • Potent adenosine A1 receptor antagonist, IC50 17.2 nM.
  • Molecular weight 375.46 g·mol⁻¹; formula C23H25N3O2.
  • Recommended solvent DMSO at 100 mg/mL; may require ultrasonication.
  • Storage: powder -20°C (up to 3 years), 4°C (up to 2 years); in solvent -80°C (6 months), -20°C (1 month).
  • Suitable for in vitro pharmacology and receptor binding studies.

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11

Medchemexpress LLC (E)-1-[(2R)-2-(2-hydroxyethyl)piperidin-1-yl]-3-(2-phenylpyrazolo[1,5-a]pyridin-3-yl)prop-2-en-1-one | 121524-18-3 | 99.2% | 375.46 | C23H25N3O2 | 10 MG
SDP

FK 453 is a potent, selective adenosine A1 receptor antagonist intended for research use. It inhibits human A1 receptor activity with an IC50 of 17.2 nM, appears as an off-white to light yellow solid, and also shows activity at adenosine A2B and in primary rat hepatocytes.

  • Potent adenosine A1 receptor antagonist (IC50 17.2 nM).
  • Additional activity at adenosine A2B (cAMP accumulation IC50 0.98 μM).
  • Inhibits NECA-induced glucose production in primary rat hepatocytes (IC50 8.1 μM).
  • High purity: 99.2%.
  • Molecular weight: 375.46.
  • Off-white to light yellow solid; soluble in DMSO (100 mg/mL).
  • Storage recommendations: powder -20°C (3 years); in solvent -80°C (6 months).

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