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Aromatic organic compounds that consist of a phenyl functional group (−C6H5) bonded to a hydroxyl functional group (−OH). Includes compounds with more substitutions and derivatives.
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h/m NRP1-sh-Puro shRNA lentiviral vector expressing with Puromycin selection for studies in Human/Mouse Each vial provides a nominal titer of 5x10E6 transducing units TU Validated h/m NRP1 shRNA Lentivirus High-titer shRNA lentiviral particles specific for human/mouse neuropilin 1 (NRP1) The shRNA has been validated to meet or exceed 70% knockdown of NRP1 using a specific fluorescence-based method that is more rapid and reliable than qPCR The lentiviral particles are ultra-purified and concentrated by PEG precipitation and sucrose gradient centrifugation and are ideal for transducing difficult-to-transfect cells including thawed and/or primary cells Order a shRNA lentivirus set and receive lentivirus produced from mix of 2 independent shRNAs validated to knockdown the target gene ( 70%) plus control lentivirus produced from mix of 2 scrambled shRNA constructs
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h/m SREBP2-sh-RFP-BSD shRNA lentiviral vector expressing RFP with Blasticidin selection for studies in Human/Mouse Each vial provides a nominal titer of 5x10E6 transducing units TU Validated h/m SREBP2 shRNA Lentivirus High-titer shRNA lentiviral particles specific for human/mouse sterol regulatory element binding transcription factor 2 (SREBP2/SREBF2) The shRNA has been validated to meet or exceed 70% knockdown of SREBP2 using a specific fluorescence-based method that is more rapid and reliable than qPCR The lentiviral particles are ultra-purified and concentrated by PEG precipitation and sucrose gradient centrifugation and are ideal for transducing difficult-to-transfect cells including thawed and/or primary cells Order a shRNA lentivirus set and receive lentivirus produced from mix of 2 independent shRNAs validated to knockdown the target gene ( 70%) plus control lentivirus produced from mix of 2 scrambled shRNA constructs
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h/m EGFR-sh-RFP-Puro shRNA lentiviral vector expressing RFP with Puromycin selection for studies in Human/Mouse Each vial provides a nominal titer of 5x10E6 transducing units TU Validated h/m EGFR shRNA Lentivirus High-titer shRNA lentiviral particles specific for human/mouse epidermal growth factor receptor (EGFR) The shRNA has been validated to meet or exceed 70% knockdown of EGFR using a specific fluorescence-based method that is more rapid and reliable than qPCR The lentiviral particles are ultra-purified and concentrated by PEG precipitation and sucrose gradient centrifugation and are ideal for transducing difficult-to-transfect cells including thawed and/or primary cells Order a shRNA lentivirus set and receive lentivirus produced from mix of 2 independent shRNAs validated to knockdown the target gene ( 70%) plus control lentivirus produced from mix of 2 scrambled shRNA constructs
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Dehydrothio-p-toluidine (DHPT) is a chemical intermediate used in dyestuff production and related industrial dye synthesis. It is supplied as a light yellow to green yellow solid with a high stated purity and is intended for research or industrial intermediate use; it is not for human or clinical applications.
Chemical intermediate for dyestuff production
Light yellow to green yellow solid appearance
High stated purity (99.9%)
Available documentation: datasheet, COA, and SDS
Shows inhalation toxicity; handle with appropriate controls
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SKI-178 is a potent inhibitor of both sphingosine kinase-1 (SphK1) and SphK2. It exhibits cytotoxicity at IC50 concentrations ranging from 0.1 to 1.8 μM in various cancer cell lines, including those resistant to multiple agents. This compound has been shown to induce apoptosis in human acute myeloid leukemia cell lines through a CDK1-dependent mechanism.
Potent sphingosine kinase-1 and SphK2 inhibitor
Exhibits cytotoxicity in various cancer cell lines
Induces apoptosis in a CDK1-dependent manner
Inhibits leukemic progression in an MLL-AF9 mouse model
Suitable for in vitro and in vivo studies
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5 -O-[Bis(4-methoxyphenyl)phenylmethyl]-adenosine is an adenosine analog Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression Its popular products are adenosine phosphate Acadesine (HY-13417) Clofarabine (HY-A0005) Fludarabine phosphate (HY-B0028) and Vidarabine (HY-B0277)[1]
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Bemotrizinol (Tinosorb S) a compound that can absorb ultraviolet light has been shown to accept atomic oxygen generated by N-oxide photodeoxygenation[1][2][3][4]
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Bromophenol blue indicator (3 0-4 6) is a synthetic dye commonly used as an acid-base indicator with a transition range of pH 3 0-4 6 Bromophenol blue indicator (3 0-4 6) is water soluble and changes color from yellow to blue as the pH of the solution changes from acidic to basic Its unique chemical properties make it an important ingredient in a variety of scientific applications especially in biochemistry and molecular biology In addition it can be used as a stain in microbiology and histology However Bromophenol blue indicator (3 0-4 6) has potential irritating and staining properties
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hsa-miR-21-5p antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs The miRNA antagomirs have 2 phosphorothioates at the 5 end 4 phosphorothioates at the 3 end 1 cholesterol group at the 3 end and full-length nucleotide 2 -methoxy modification The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes thereby inhibiting miRNAs from functioning Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors they exhibits enhanced cellular uptake stability and regulatory activity in vivo
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