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Organic compounds that contain a carboxyl group bonded to an organic functional group; carboxyl groups consist of a carbonyl group bonded to a hydroxy group. Includes compounds that are derived from carboxylic acids.
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CA-074 Me (CAS 147859-80-1) is a cell-permeable methyl ester derivative of CA-074 functioning primarily as a selective inhibitor of cathepsin B It exhibits potent inhibitory activity against cathepsin B (IC50 36 3 nM) In cultured human gingival fibroblasts CA-074 Me effectively suppresses cathepsin B activity while moderately reducing combined cathepsin B and L activities Under strong reducing conditions (e g presence of DTT or GSH) CA-074 Me inhibits cathepsin L substantially Thus it is widely utilized in biomedical research to study lysosomal enzyme functions and roles of cathepsins in cellular processes
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Methyl stearate, isolated from Rheum palmatum L., is a component of soybean and rapeseed biodiesels. It inhibits the egg hatching of root-knot nematode (Meloidogyne incognita) and has a repellent effect on second-stage larvae (J2s), thereby reducing nematode infection of plants.
Component of soybean and rapeseed biodiesels
Inhibits egg hatching of root-knot nematode
Repellent effect on second-stage larvae (J2s)
Reduces nematode infection of plants
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Neratinib maleate is an orally available, irreversible, highly selective HER2 and EGFR inhibitor with IC50s of 59 nM and 92 nM, respectively. It is for research use only.
Orally available
Irreversible inhibitor
Highly selective HER2 and EGFR inhibitor
Inhibits proliferation of cell lines with high HER-2 levels
Less active in cell lines expressing neither HER-2 nor EGFR
Arrests BT474 cell cycle at G1-S phase
Inhibits MAPK and Akt phosphorylation
Down-regulates cyclin D1 levels
Induces p27
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