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Organic compounds that contain a carboxyl group bonded to an organic functional group; carboxyl groups consist of a carbonyl group bonded to a hydroxy group. Includes compounds that are derived from carboxylic acids.
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CA-074 is a potent, selective inhibitor of cathepsin B with a reported Ki of 2-5 nM, used in biochemical and cell-based research to study cysteine protease activity. It is an epoxysuccinyl peptide derivative with typical purity over 98% and a molecular weight of 383.44 g/mol.
Potent cathepsin B inhibition with Ki of 2-5 nM.
Suitable for biochemical and cell-based assays.
Typical purity greater than 98% (HPLC).
Molecular formula C18H29N3O6 and molecular weight 383.44 g/mol.
Available in multiple pack sizes, including 100 MG, for research use.
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CA-074 methyl ester is a selective, cell-permeable inhibitor of cathepsin B used in biochemical and cellular research to probe cathepsin-mediated pathways. It is commonly used in studies of neuroprotection, cancer biology, and inflammation where targeted inhibition of cathepsin B activity is required.
Selective inhibition of cathepsin B in biochemical assays.
Cell-permeable to enable intracellular targeting in cell-based studies.
High purity suitable for analytical and research applications.
Comes with supporting documentation including a datasheet and COA.
Available in multiple pack sizes to accommodate different experimental needs.
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CA-074 is a potent, selective inhibitor of cathepsin B with a reported Ki of 2-5 nM (CAS 134448-10-5). It is supplied as a research-grade solid for biochemical and cell-based studies of cathepsin B-dependent processes.
Potent inhibitor of cathepsin B (Ki = 2-5 nM).
High purity by HPLC (>98%).
Molecular weight 383.44 g/mol.
Chemical formula C18H29N3O6.
White to off-white powder appearance.
Intended for research use only.
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Silvestrol is a natural product isolated from Agave americana that inhibits eukaryotic translation initiation factor 4A (eIF4A) and is used as a research reagent to study translation regulation, autophagy, and apoptosis.
Inhibits eIF4A-mediated translation.
Induces autophagy and caspase-mediated apoptosis.
Exhibits cytotoxic activity in human cancer cell lines.
Supplied as a powder for research use.
Purity >98.0%.
Available in small pack sizes (1 mg-10 mg).
Recommended storage: powder -20°C (3 years) or 4°C (2 years).
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Z-WEHD-FMK is a potent, cell-permeable, and irreversible caspase-1/5 inhibitor. It also exhibits a robust inhibitory effect on cathepsin B activity (IC50=6 μM) and can be used to investigate cells for evidence of apoptosis.
Potent, cell-permeable and irreversible caspase-1/5 inhibitor
Exhibits robust inhibitory effect on cathepsin B activity
Can be used to investigate cells for evidence of apoptosis
Elicits near-complete blockage of C. trachomatis-induced cleavage of golgin-84
Inhibits E. piscicida-induced ZF4 cells cytotoxicity and pyroptotic morphology
Significantly induces a decrease in IL-1β release in bone marrow-derived macrophages
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Medchemexpress, HY-15876 5mg Clopidogrel thiolactone CAS:1147350-75-1 Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
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CA-074 is a potent, selective inhibitor of cathepsin B (Ki = 2-5 nM) commonly supplied as a 10 mM solution in DMSO for use in biochemical and cellular research. The compound has molecular formula C18H29N3O6 and a molecular weight of 383.44 g·mol⁻¹.
Potent cathepsin B inhibition with Ki = 2-5 nM.
Supplied as a 10 mM solution, 1 mL vial, ready for in vitro use.
Soluble in DMSO; example in vitro stock concentrations provided by the manufacturer.
Storage guidance: powder -20 °C; in solvent -80 °C (up to 6 months) or -20 °C (up to 1 month).
Molecular formula C18H29N3O6; molecular weight 383.44 g·mol⁻¹.
Intended for research use only (not for human or veterinary use).
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Also available in 1 mg 2 mg 10 mg 25 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. CA-074 methyl ester (Cathepsin B Inhibitor IV) is a specific inhibitor of Cathepsin B with neuroprotective anti-cancer and anti-inflammatory effects. purity: 99%
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CA 074 (CAS 134448-10-5) is a selective inhibitor of cathepsin B a cysteine protease involved in diverse pathological mechanisms By targeting cathepsin B CA 074 alleviates neurotoxicity induced by amyloid-activated microglia and inhibits proteolytic cascades associated with cell growth suppression and plasminogen activation Additionally CA 074 treatment modulates immune responses by shifting CD4 T cells from a Th2 to a Th1 phenotype reducing IgE and IgG1 levels In vivo studies indicate that CA 074 can attenuate TNF- -induced hepatic injury highlighting its relevance as a research tool in inflammation immunology and neurodegenerative disease investigations
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