Oligomycin A (MCH 32), created by Streptomyces, acts as a mitochondrial F0F1-ATPase inhibitor with a Ki of 1 μM. It also shows anti-fungal activity, is cytotoxic to NCI-60 cell lines (GI50 of 10 nM), and inhibits the activity of Triton X-100-solubilized ATPase. It suppresses progesterone-induced in vitro acrosome exocytosis (IVAE) and concomitant O2 consumption and ATP levels.
- Acts as a mitochondrial F0F1-ATPase inhibitor
- Shows anti-fungal activity
- Cytotoxic to NCI-60 cell lines
- Inhibits activity of Triton X-100-solubilized ATPase
- Suppresses progesterone-induced in vitro acrosome exocytosis (IVAE)
- Inhibits spermatozoa's ability to achieve feasible in vitro capacitation (IVC)