Aniline and substituted anilines
Medchemexpress LLC TC LPA5 4 5mg | 1393814-38-4 | 5MG
TC LPA5 4 is a LPA5 (GPR92)-specific non-lipid antagonist TC LPA5 4 inhibits LPA-induced aggregation of isolated human platelet (LPA5-RH7777 cell line) with an IC50 of 800 nM TC LPA5 4 displays selectivity for LPA5 over 80 other screened agent targets[1 TC LPA5 4 inhibits cell proliferation and migration of thyroid cancer cells[2
Medchemexpress LLC 5-(3-chloro-4-cyclohexylphenyl)-1-(3-methoxyphenyl)-1H-pyrazole-3-carboxylic acid | 1393814-38-4 | MFCD26792575 | 99.7% | 410.89 g·mol-1 | C23H23ClN2O3 | 10 MG
TC LPA5 4 is a selective, non-lipid antagonist of the lysophosphatidic acid receptor 5 (LPA5/GPR92) used as a research tool to probe LPA5 signaling. It inhibits LPA-induced platelet aggregation (IC50 ≈ 0.8 μM) and has been reported to reduce proliferation and migration in certain cancer cell lines. The compound is provided with high reported purity and DMSO solubility for preparation of concentrated stock solutions.
- Selective LPA5 antagonist suitable for receptor signaling studies.
- Non-lipid, small-molecule antagonist with reported IC50 ~0.8 μM.
- Inhibits LPA-induced platelet aggregation and cell migration.
- High reported purity appropriate for biochemical and cell-based assays.
- High solubility in DMSO for convenient stock preparation.
Medchemexpress LLC 5-(3-chloro-4-cyclohexylphenyl)-1-(3-methoxyphenyl)-1H-pyrazole-3-carboxylic acid | 1393814-38-4 | 99.7% | 410.89 | C23H23ClN2O3 | 100 MG
TC LPA5 4 is a selective, non-lipid antagonist of the lysophosphatidic acid receptor LPA5 (GPR92). It inhibits LPA-induced platelet aggregation and reduces proliferation and migration in certain cancer cell lines, with reported IC50 ≈ 0.8 μM in LPA5-RH7777 cells. Supplied as a high-purity research compound (C23H23ClN2O3, MW 410.89).
- Selective LPA5 receptor antagonist suitable for receptor pharmacology studies.
- Inhibits LPA-induced platelet aggregation with low micromolar potency.
- High purity for reliable biological assay results.
- Characterized by molecular formula C23H23ClN2O3 and MW 410.89.
- Available in milligram-scale packs for preclinical research.
![Medchemexpress LLC 5-bromo-2-(4-fluorophenyl)-3-[4-(methylsulfonyl)phenyl]-thiophene | 88149-94-4 | MFCD02684527 | 99.8% | 411.31 | C17H12BrFO2S2 | 5 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000244742.png-250.jpg)
Medchemexpress LLC 5-bromo-2-(4-fluorophenyl)-3-[4-(methylsulfonyl)phenyl]-thiophene | 88149-94-4 | MFCD02684527 | 99.8% | 411.31 | C17H12BrFO2S2 | 5 MG
DuP-697 (CAS 88149-94-4) is a selective, irreversible cyclooxygenase-2 (COX-2) inhibitor provided as a solid research reagent for biochemical and cell-based assays. It exhibits potent inhibition of human COX-2 with marked selectivity over COX-1 and is used to investigate prostaglandin-mediated inflammation and related pharmacology.
- Selective, irreversible COX-2 inhibitor with hCOX-2 IC50 = 10 nM.
- High purity solid suitable for biochemical and cell-based assays.
- Demonstrates activity in cellular models and animal inflammation assays.
- Stable as a powder at -20°C for long-term storage; limit solvent storage to -80°C for extended periods.
- Useful tool compound for studies of prostaglandin synthesis and inflammation pathways.
Medchemexpress LLC TC LPA5 4 | 1393814-38-4 | 99.7% | 410.89 | C23H23ClN2O3 | 50 MG
TC LPA5 4 is a selective, non-lipid antagonist of the lysophosphatidic acid receptor LPA5 used in research to probe LPA5-mediated signaling. It exhibits antagonist activity at human LPA5 (cellular IC50 ~0.8 μM), inhibits LPA-induced platelet aggregation, reduces proliferation and migration of thyroid cancer cells in vitro, and has shown efficacy in mouse xenograft studies.
Apexbio Technology LLC DuP 697 88149-94-4 50mg
DuP 697 (CAS 88149-94-4) is an ortho-diaryl heterocyclic compound that selectively and irreversibly inhibits cyclooxygenase-2 (COX-2) displaying an IC50 of 10 nM for human COX-2 and 800 nM for COX-1 DuP 697 is demonstrated to suppress prostaglandin synthesis and in vitro exhibits antiproliferative pro-apoptotic and anti-angiogenic effects in HT29 colorectal cancer cells (IC50 42 8 nM) This small molecule is commonly utilized to explore COX-2-mediated inflammatory pathways as well as tumor biology providing a valuable tool for dissecting mechanisms underlying inflammation and cancer
Apexbio Technology LLC DuP 697 88149-94-4 10mg
DuP 697 (CAS 88149-94-4) is an ortho-diaryl heterocyclic compound that selectively and irreversibly inhibits cyclooxygenase-2 (COX-2) displaying an IC50 of 10 nM for human COX-2 and 800 nM for COX-1 DuP 697 is demonstrated to suppress prostaglandin synthesis and in vitro exhibits antiproliferative pro-apoptotic and anti-angiogenic effects in HT29 colorectal cancer cells (IC50 42 8 nM) This small molecule is commonly utilized to explore COX-2-mediated inflammatory pathways as well as tumor biology providing a valuable tool for dissecting mechanisms underlying inflammation and cancer
Medchemexpress LLC 5-bromo-2-(4-fluorophenyl)-3-(4-methylsulfonylphenyl)thiophene | 88149-94-4 | MFCD02684527 | 99.8% | 411.31 g·mol⁻¹ | C17H12BrFO2S2 | 10 MG
DuP-697 (CAS 88149-94-4) is a selective, irreversible cyclooxygenase-2 (COX-2) inhibitor used as a research chemical. It inhibits prostaglandin synthesis and has demonstrated antiproliferative, antiangiogenic, and antipyretic effects in cellular studies. The compound is provided as a high-purity solid for biochemical assays and preclinical research; it is not intended for human or veterinary use.
- Selective, irreversible COX-2 inhibition (IC50 ≈ 10 nM for human COX-2)
- Minimal COX-1 activity (IC50 ≈ 800 nM for human COX-1)
- High purity (≈99.8%) suitable for analytical and biological studies
- Molecular weight 411.31 g·mol⁻¹; formula C17H12BrFO2S2
- Suitable for biochemical assays and cell-based research; research use only