Benzenesulfonamides
Medchemexpress LLC HY-112438 5mg Medchemexpress, MF-094 CAS:2241025-68-1 Purity:>98%
Medchemexpress, HY-112438 5mg MF-094 CAS:2241025-68-1 MF-094 is a potent and selective USP30 inhibitor with an IC 50 of 120 nM. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
eMolecules 97-04-1 | ChemScene | 2-Chloro-5-sulfamoylbenzoic acid | 100mg | 761228608 | CS-0462903 | MFCD00036103 | 235.64 | C7H6ClNO4S
ChemScene | 2-Chloro-5-sulfamoylbenzoic acid | 100mg | 761228608 | CS-0462903 | 97-04-1 | MFCD00036103 | 235.640 | C7H6ClNO4S
AdipoGen Glimepiride (1 g)
Chemical. CAS: 93479-97-1. Formula: C24H34N4O5S. MW: 490.62. Glimepiride is a long-acting sulfonylurea antidiabetic agent inhibiting ATP-sensitive potassium (KATP) channels in pancreatic beta-cells, which leads to the release of insulin. In addition, Glimepiride increases the activity of intracellular insulin receptors. Studies conducted on adipocytes and skeletal muscle suggest that Glimepiride induces the PI3 kinase (PI3K) and Akt pathway, along with insulin receptor substrate-1/2 and endothelial nitric oxide synthase and stimulates glucose transporter 1 and 4 (GLUT1/4) expression. Glimepiride also increases osteoblast proliferation and differentiation, which is thought to be related to its ability to activate the PI3K and Akt pathway and exhibits neuroprotective benefit, decreasing expression and activity of BACE1 and amyloid-beta (Abeta) in neurons in a PPARgamma-dependent manner.
Frontier Specialty Chemicals 5G 4-BROMO-N,N-DIMETHYLBENZENE
4-Bromo-N,N-dimethylbenzenesulfonamide; CAS No: 707-60-8
Medchemexpress LLC HY-16586 10mg Medchemexpress, PFI-1 CAS:1403764-72-6 Purity:>98%
Medchemexpress, HY-16586 10mg PFI-1 CAS:1403764-72-6 PFI-1 is a selective BET (bromodomain-containing protein) inhibitor for BRD4 with IC50 of 0.22 μM in a cell-free assay. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Apexbio Technology LLC Sulfasalazine 599-79-1 10mM (in 1mL DMSO)
Sulfasalazine (599-79-1) is a small-molecule inhibitor targeting the NF- B signaling pathway and the cystine-glutamate antiporter system (system Xc-) It is designed to suppress NF- B activation and inhibit cystine uptake thereby modulating inflammatory gene expression and intracellular glutathione synthesis Sulfasalazine exerts its biological activity primarily through inhibition of NF- B activation and blockade of system Xc- In in vitro studies sulfasalazine demonstrates growth inhibition and induction of apoptosis in several cancer cell lines including MIA PaCa-2 PANC-1 and glioblastoma cells with reported IC50 values ranging from approximately 0 2 to 0 5 mM depending on cell type and conditions Based on these pharmacological properties sulfasalazine holds research potential in inflammation NF- B signaling oxidative stress modulation and cancer studies
Apexbio Technology LLC Glibenclamide 10238-21-8 10mM (in 1mL DMSO)
Glibenclamide (CAS 10238-21-8) is a sulfonylurea-class small molecule widely utilized in biomedical research for its ability to modulate insulin release It acts primarily by binding to ATP-sensitive potassium channels (K ATP channels) in pancreatic beta cells This interaction results in channel closure leading to cellular depolarization calcium ion influx and subsequent insulin secretion Due to its well-characterized mechanism glibenclamide is particularly relevant in diabetes-related research focusing on insulin regulation and beta-cell physiology
eMolecules 1349796-36-6 | XL765 Analogue | MFCD18252649 | 50mg
Medchem Express | 680C91 | 5mg | 721309296 | HY-108681 | 163239-22-3 | MFCD20926361 | 238.265 | C15H11FN2
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Cayman Chemical GlImepIrIde 500mg
An inhibitor of SUR1/Kir6.2, SUR2A/Kir6.2, and SUR2B/Kir6.2 (IC50s = 3, 5.4, and 7.3 nM, respectively, in Xenopus oocytes expressing the mouse receptor); induces InsR complex dissociation and insulin degradation in HepG2 cells at 20 µM; decreases blood glucose and plasma insulin levels in a KKAy mouse model of insulin-resistant type 2 diabetes at 0.05 mg/kg per day; reduces HbA1c levels in the same model at 0.5 mg/kg per day
eMolecules 957060-91-2 | 4-(N-(4-Methoxybenzyl)sulfamoyl)phenylboronic acid | Combi-Blocks | MFCD09027228 | 321.150 | C14H16BNO5S | 98.000 | COc1ccc(CNS(=O)(=O)c2ccc(cc2)B(O)O)cc1 | 1g | 117522926
4-(N-(4-Methoxybenzyl)sulfamoyl)phenylboronic acid | Combi-Blocks | 957060-91-2 | MFCD09027228 | 321.150 | C14H16BNO5S | 98.000 | COc1ccc(CNS(=O)(=O)c2ccc(cc2)B(O)O)cc1 | 1g | 117522926
Medchemexpress LLC HY-B0442A 100mg Medchemexpress, Vardenafil (hydrochloride) CAS:224785-91-5 Purity:>98%
Medchemexpress, HY-B0442A 100mg Vardenafil (hydrochloride) CAS:224785-91-5 Vardenafil hydrochloride is a selective, orally active, potent inhibitor of phosphodiesterase-5 (PDE5), with an IC50 of 0.7 nM. Vardenafil hydrochloride shows selectivity over PDE1 (180 nM), PDE6 (11 nM), PDE2, PDE3, and PDE4 (>1000 nM). Vardenafil hydrochloride competitively inhibits cyclic guanosine monophosphate (cGMP) hydrolysis and thus increases cGMP levels. Vardenafil hydrochloride can be used for the research of erectile dysfunction. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Apexbio Technology LLC Bosentan 147536-97-8 50mg
Bosentan (CAS 147536-97-8) is a small molecule that acts as a competitive antagonist at both endothelin-A (ET-A) and endothelin-B (ET-B) receptors By blocking the binding of endothelin-1 to these receptors bosentan modulates endothelin-mediated vasoconstriction and cellular proliferation pathways This compound is utilized in biomedical research to investigate the endothelin signaling axis and its role in cardiovascular physiology pulmonary hypertension and related pathologies Bosentan enables the study of receptor-specific effects of endothelin-1 inhibition and offers a tool for evaluating therapeutic strategies targeting the endothelin system