Benzenesulfonamides
Apexbio Technology LLC Bosentan Hydrate 157212-55-0 50mg
Bosentan Hydrate (CAS 157212-55-0) is a sulfonamide-derived competitive antagonist of endothelin receptors exhibiting preferential affinity toward endothelin A over endothelin B receptors By interfering with endothelin-triggered signaling in endothelial and vascular smooth muscle cells it attenuates vasoconstrictive and bronchoconstrictive responses In vitro studies revealed bosentan inhibited endothelin receptor activity in P388/dx cells (IC50 15 1 1 6 M) and effectively reversed antiangiogenic effects of systemic sclerosis patient sera on dermal microvascular endothelial cells In animal models bosentan administration post-myocardial infarction significantly elevated plasma leptin levels Clinically bosentan is applied extensively in research on pulmonary arterial hypertension showing beneficial outcomes on patients exercise capacity
eMolecules 342404-46-0 | 1-(Phenylsulfonyl)indole-2-boronic acid | Combi-Blocks | MFCD03086094 | 301.120 | C14H12BNO4S | 96.000 | OB(O)c1cc2ccccc2n1S(=O)(=O)c1ccccc1 | 1g | 117525753
1-(Phenylsulfonyl)indole-2-boronic acid | Combi-Blocks | 342404-46-0 | MFCD03086094 | 301.120 | C14H12BNO4S | 96.000 | OB(O)c1cc2ccccc2n1S(=O)(=O)c1ccccc1 | 1g | 117525753
Medchemexpress LLC HY-10858 5mg Medchemexpress, WAY 316606 CAS:915759-45-4 Purity:>98%
Medchemexpress, HY-10858 5mg WAY 316606 CAS:915759-45-4 WAY 316606 is an inhibitor of the secreted protein sFRP-1, an endogenous antagonist of the secreted glycoprotein Wnt. The affinity of WAY-316606 for sFRP-1 is determined using the FP binding assay with IC50 of 0.5 μM. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC HY-15833 50mg , Chlorthalidone CAS:77-36-1 Purity:98%
Medchemexpress, HY-15833 50mg Chlorthalidone CAS:77-36-1 Formula:C14H11ClN2O4S Purity:98% Chlorthalidone is a thiazide-like diuretic used to treat hypertension. Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
![eMolecules 31696-45-4 | Ethyl 3-[(phenylsulfonyl)oxy]-5-isoxazoleacetate | Synthonix311.310 | C13H13NO6S | 97.000 | CCOC(=O)Cc1cc(OS(=O)(=O)c2ccccc2)no1 | 10mg | 786491789](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502456934.PNG-250.jpg)
eMolecules 31696-45-4 | Ethyl 3-[(phenylsulfonyl)oxy]-5-isoxazoleacetate | Synthonix311.310 | C13H13NO6S | 97.000 | CCOC(=O)Cc1cc(OS(=O)(=O)c2ccccc2)no1 | 10mg | 786491789
Ethyl 3-[(phenylsulfonyl)oxy]-5-isoxazoleacetate | Synthonix | 31696-45-4311.310 | C13H13NO6S | 97.000 | CCOC(=O)Cc1cc(OS(=O)(=O)c2ccccc2)no1 | 10mg | 786491789
Medchemexpress LLC GW806742X hydrochloride | 98.3% | 610.01 | 100 MG
GW806742X hydrochloride is an ATP mimetic and a potent inhibitor of MLKL (Mixed Lineage Kinase Domain-Like protein), binding to the MLKL pseudokinase domain with a Kd of 9.3 μM. It also exhibits activity against VEGFR2 with an IC50 of 2 nM. This compound has been shown to retard MLKL membrane translocation and inhibit necroptosis.
- Retards MLKL membrane translocation
- Inhibits necroptosis
- Inhibits necroptotic death of wild-type mouse dermal fibroblasts (MDFs) stimulated with TSQ in a dose-dependent manner
- Inhibits VEGF-induced proliferation of HUVECs with an IC50 of 5 nM
- Binds MLKL pseudokinase domain with a Kd of 9.3 μM
- Activity against VEGFR2 with an IC50 of 2 nM
Medchemexpress LLC Tolazamide | 1156-19-0 | MFCD00083504 | 99.9% | 100 MG
Tolazamide (U-17835) is an orally active sulfonylurea agent that inhibits sulfonylurea receptor 1 (SUR1) linked to the inwardly rectifying potassium channel (IC50 = 4.2 μM in HEK293 cells transfected with the human receptor). It possesses anti-diabetic properties, lowering blood glucose in the sulfonylurea class. Tolazamide decreases insulin dose while maintaining adequate metabolic control and can improve or normalize hyperglycemia and HbA.
- Orally active sulfonylurea agent
- Inhibits sulfonylurea receptor 1 (SUR1)
- Lowers blood glucose
- Decreases insulin dose while maintaining metabolic control
- Improves or normalizes hyperglycemia and HbA
- Attenuates gluconeogenesis and ketogenesis in diabetic rats
Medchemexpress LLC HY-15531 50mg Medchemexpress, Venetoclax CAS:1257044-40-8 Purity:>98%
Medchemexpress, HY-15531 50mg Venetoclax CAS:1257044-40-8 Venetoclax (ABT-199; GDC-0199) is a highly potent, selective and orally bioavailable Bcl-2 inhibitor with a Ki of less than 0.01 nM. Venetoclax induces autophagy[2][3]. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
![eMolecules 171599-83-0 | Sildenafil citrate | Target Molecule | MFCD09026931 | 666.700 | C28H38N6O11S | 0.000 | OC(=O)CC(O)(CC(O)=O)C(O)=O.CCCc1nn(C)c2c1nc([nH]c2=O)-c1cc(ccc1OCC)S(=O)(=O)N1CCN(C)CC1 | 500mg | 574599324](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000126977.jpg-250.jpg)
eMolecules 171599-83-0 | Sildenafil citrate | Target Molecule | MFCD09026931 | 666.700 | C28H38N6O11S | 0.000 | OC(=O)CC(O)(CC(O)=O)C(O)=O.CCCc1nn(C)c2c1nc([nH]c2=O)-c1cc(ccc1OCC)S(=O)(=O)N1CCN(C)CC1 | 500mg | 574599324
Sildenafil citrate | Target Molecule | 171599-83-0 | MFCD09026931 | 666.700 | C28H38N6O11S | 0.000 | OC(=O)CC(O)(CC(O)=O)C(O)=O.CCCc1nn(C)c2c1nc([nH]c2=O)-c1cc(ccc1OCC)S(=O)(=O)N1CCN(C)CC1 | 500mg | 574599324
AdipoGen Glimepiride (250 mg)
Chemical. CAS: 93479-97-1. Formula: C24H34N4O5S. MW: 490.62. Glimepiride is a long-acting sulfonylurea antidiabetic agent inhibiting ATP-sensitive potassium (KATP) channels in pancreatic beta-cells, which leads to the release of insulin. In addition, Glimepiride increases the activity of intracellular insulin receptors. Studies conducted on adipocytes and skeletal muscle suggest that Glimepiride induces the PI3 kinase (PI3K) and Akt pathway, along with insulin receptor substrate-1/2 and endothelial nitric oxide synthase and stimulates glucose transporter 1 and 4 (GLUT1/4) expression. Glimepiride also increases osteoblast proliferation and differentiation, which is thought to be related to its ability to activate the PI3K and Akt pathway and exhibits neuroprotective benefit, decreasing expression and activity of BACE1 and amyloid-beta (Abeta) in neurons in a PPARgamma-dependent manner.
Medchemexpress LLC HY-111383 5mg Medchemexpress, LX2343 CAS:333745-53-2 Purity:>98%
Medchemexpress, HY-111383 5mg LX2343 CAS:333745-53-2 LX2343 is a BACE1 enzyme inhibitor with an IC50 value of 11.43±0.36 μM. LX2343 acts as a non-ATP competitive PI3K inhibitor with an IC50 of 15.99±3.23 μM. LX2343 stimulates autophagy in its promotion of Aβ clearance. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC HY-18054 5mg Medchemexpress, BVT 2733 CAS:376640-41-4 Purity:>98%
Medchemexpress, HY-18054 5mg BVT 2733 CAS:376640-41-4 BVT 2733 is a potent, selective, and orally active non-steroidal 11β-hydroxydehydrogenase 1 (11β-HSD1) inhibitor. BVT 2733 is potently against the mouse enzyme (IC50=96 nM) over the human enzyme (IC50=3341 nM). BVT 2733 has the potential for the study of arthritis and obesity related disease. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
eMolecules 151720-43-3 | Medchem Express | Oxamflatin | 1mg | 446257610 | HY-102033 | MFCD00949087 | 342.37 | C17H14N2O4S
ChemScene | 1-Methyl-1H-indole-6-carbonitrile | 1g | 791178640 | CS-0043605 | 20996-87-6 | MFCD08690254 | 156.188 | C10H8N2
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Medchemexpress LLC Sildenafil (citrate) | 171599-83-0 | C28H38N6O11S | 5 G
Sildenafil citrate is a potent phosphodiesterase type 5 (PDE5) inhibitor with an IC50 of 5.22 nM. It is intended for research use only.
- Potent phosphodiesterase type 5 (PDE5) inhibitor with IC50 of 5.22 nM.
- Potentiates phosphorylation of ERK1/ERK2.
- Increases percentage of cells in S phase and cell proliferation.
- Enhances upregulation of ERK1/ERK2 phosphorylation induced by serotonin.
- Increases intracavernosal pressure (ICP) and ICP/BP in dog models.
- Reduces the number of TL+-cells and microglia/macrophages in ischemic models.
- Decreases flap necrosis by increasing growth factors (FGF and VEGF).
- Used in clinical trials for pulmonary arterial hypertension, erectile dysfunction, spinal cord injuries, pregnancy complication, cancer, and more.