Benzenesulfonic acids and derivatives
Medchemexpress LLC QL-X-138 | 1469988-63-3 | 99.8% | 421.45 | C25H19N5O2 | 1MG
QL-X-138 is a small-molecule BTK/MNK dual kinase inhibitor that covalently binds to BTK and non-covalently to MNK. It is provided as a high-purity solid for laboratory research and has been characterized in preclinical studies for activity against hematologic malignancies and dengue virus.
- Dual inhibition of Bruton tyrosine kinase (BTK) and MAPK-interacting kinase (MNK).
- Covalent binding to BTK and non-covalent binding to MNK.
- High-purity solid form suitable for laboratory research.
- Molecular formula C25H19N5O2 and molecular weight 421.45.
- Demonstrated preclinical activity in models of lymphoma, leukemia, and dengue virus.
- For research use only; not for human or clinical use.
Medchemexpress LLC I-138 | 2098211-50-6 | C26H23F3N6O | 25 MG
I-138 is an orally active, reversible inhibitor of USP1-UAF1, with an IC50 of 4.1 nM and a Ki of 5.4 nM. It induces monoubiquitination of FANCD2 and PCNA in cells and eliminates USP1 autocleavage in cells. It is structurally related to ML323.
- Reversible inhibitor of USP1-UAF1
- Induces monoubiquitination of FANCD2 and PCNA in cells
- Eliminates USP1 autocleavage in cells
- Inhibits MDA-MB-436 cell viability
- Shows modest antitumor activity in mice bearing MDA-MB-436 tumors
- Can be combined with Niraparib for BRCA1/2 mutant tumor inhibition
Medchemexpress LLC I-138 | 2098211-50-6 | C26H23F3N6O | 1 MG
I-138 is an orally active, reversible inhibitor of USP1-UAF1 (IC50: 4.1 nM; Ki: 5.4 nM), structurally related to ML323 (HY-17543). I-138 induces monoubiquitination of FANCD2 and PCNA in cells and eliminates USP1 autocleavage in cells.
- Orally active and reversible inhibitor of USP1-UAF1.
- Potent inhibitory activity against USP1-UAF1 (IC50: 4.1 nM; Ki: 5.4 nM).
- Induces monoubiquitination of FANCD2 and PCNA in cells.
- Eliminates USP1 autocleavage in cells.
- Demonstrates modest antitumor activity in mice bearing MDA-MB-436 tumors.
- Shows enhanced inhibition of BRCA1/2 mutant tumors in vivo when combined with the PARP inhibitor Niraparib.
Cayman Chemical 2 4-Dinitrobenzenesulfonic Ac
A hapten; induces the proliferation of primary lymphocytes and epithelial cells isolated from 2,4-DNCB-sensitized guinea pigs at 25, 50, or 100 ppm; inhibits 2,4-DNCB-induced contact sensitivity in 2,4-DNCB-sensitized guinea pigs at 600 mg/kg; has been used to induce ulcerative colitis in rats
Medchemexpress LLC I-138 | 2098211-50-6 | C26H23F3N6O | 100 MG
I-138 is an orally active, reversible inhibitor of USP1-UAF1. It induces monoubiquitination of FANCD2 and PCNA in cells and eliminates USP1 autocleavage. This compound is structurally related to ML323.
- Orally active and reversible inhibitor of USP1-UAF1
- Induces monoubiquitination of FANCD2 and PCNA in cells
- Eliminates USP1 autocleavage in cells
- Shows dose-dependent inhibition of MDA-MB-436 cell viability
- Exhibits modest antitumor activity in mice bearing MDA-MB-436 tumors
- Can be combined with Niraparib for BRCA1/2 mutant tumor inhibition in vivo
Medchemexpress LLC I-138 | 2098211-50-6 | C26H23F3N6O | 50 MG
I-138 is an orally active, reversible inhibitor of USP1-UAF1 (IC50: 4.1 nM; Ki: 5.4 nM), structurally related to ML323. It induces monoubiquitination of FANCD2 and PCNA in cells and eliminates USP1 autocleavage in cells.
- Eliminates USP1 self-lysis in HAP-1 USP1 WT and knockout cells
- Induces monoubiquitination of FANCD2 and PCNA in MDA-MB-436 cells
- Dose-dependently inhibits MDA-MB-436 cell viability
- Results in USP1 inhibition and modest antitumor activity in mice bearing MDA-MB-436 tumors
- Benefits BRCA1/2 mutant tumor inhibition when combined with Niraparib
eMolecules 77182-82-2 | DL-Phosphinothricin, monoammonium salt | Apollo Scientific198.159 | C5H15N2O4P | 0.000 | N.CP(O)(=O)CCC(N)C(O)=O | 1g | 562428419
DL-Phosphinothricin, monoammonium salt | Apollo Scientific | 77182-82-2198.159 | C5H15N2O4P | 0.000 | N.CP(O)(=O)CCC(N)C(O)=O | 1g | 562428419
Medchemexpress LLC Setmelanotide monoacetate | 2759937-80-7 | 99.7% | 1177.36 g/mol | C51H72N18O11S2 | 10 MG
Setmelanotide monoacetate is a selective melanocortin 4 receptor (MC4R) agonist peptide intended for laboratory research. It is supplied as a white to off-white solid with supporting analytical data and storage guidance for both solution and bulk formats.
- Potent MC4R agonist with EC50 ≈ 0.27 nM (human and rat).
- Purity: 99.71% by HPLC.
- Molecular weight: 1177.36 g/mol.
- Chemical formula: C51H72N18O11S2.
- Physical appearance: white to off-white solid.
- Storage: store sealed at -20°C; in solvent -80°C up to 6 months, -20°C up to 1 month.
- Available pack sizes: 1 mg, 5 mg, 10 mg, 25 mg; larger sizes available by quote.
- Analytical documents available: data sheet, COA, SDS, HNMR, LCMS.
![eMolecules 17625-03-5 | 3-Sulfobenzoic acid monosodium salt | Combi-Blocks, Inc. | MFCD00066378 | 224.160 | C7H5NaO5S | 95.000 | [Na+].OC(=O)c1cccc(c1)S([O-])(=O)=O | 25g | 603138216](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502184095.JPG-250.jpg)
eMolecules 17625-03-5 | 3-Sulfobenzoic acid monosodium salt | Combi-Blocks, Inc. | MFCD00066378 | 224.160 | C7H5NaO5S | 95.000 | [Na+].OC(=O)c1cccc(c1)S([O-])(=O)=O | 25g | 603138216
3-Sulfobenzoic acid monosodium salt | Combi-Blocks, Inc. | 17625-03-5 | MFCD00066378 | 224.160 | C7H5NaO5S | 95.000 | [Na+].OC(=O)c1cccc(c1)S([O-])(=O)=O | 25g | 603138216
Medchemexpress LLC Setmelanotide (monoacetate) | 2759937-80-7 | 99.8% | 1177.36 | 25 MG
Setmelanotide (monoacetate) is a melanocortin 4 receptor (MC4R) agonist. It acts on human and rat MC4R with EC50 values of 0.27 nM and 0.28 nM, respectively, and is intended for research use only.
- Acts on human and rat MC4R
- Stable as a solid
- Suitable for research use
Medchemexpress LLC Setmelanotide monoacetate | 2759937-80-7 | 99.9% | 1177.36 | 5 MG
Setmelanotide (monoacetate) is a melanocortin 4 receptor (MC4R) agonist that acts on human and rat MC4R with EC50 values of 0.27 nM and 0.28 nM, respectively. It is for research use only and not sold to patients.
- Melanocortin 4 receptor (MC4R) agonist
- Acts on human and rat MC4R
- EC50 values of 0.27 nM (human) and 0.28 nM (rat)
- Available for bulk orders
- Supported by 8 publications in Google Scholar