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Filtered Search Results
Apexbio Technology LLC IMDK-10MG
iMDK (CAS No 881970-80-5) is a promising compound in the field of biomedical research particularly known for its potential in oncology studies Originating from extensive research efforts to identify effective anti-cancer agents iMDK functions primarily by targeting specific signaling pathways involved in cell proliferation and apoptosis such as the MAPK/ERK pathway It is known to exhibit potent in vitro activity in the nanomolar to low micromolar range making it an attractive candidate for laboratory investigations Frequently utilized in various cellular models and animal studies iMDK helps to elucidate mechanisms of tumor growth and explores potential therapeutic interventions Its role in high-throughput drug screening further highlights its importance in the discovery of novel cancer treatments Experimental concentrations typically depend on the specific research design offering flexibility in diverse experimental setups to assess its effectiveness and safety profiles
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eMolecules 2250323-50-1 | Medchem Express | JWG-071 | 5mg | 495799688 | HY-108886 | 612.779 | C34H44N8O3
Ambeed | Methyl 2-benzyl-56-dihydroxypyrimidine-4-carboxylate | 100mg | 596569375 | A851948 | 519032-07-6 | MFCD09031861 | 260.249 | C13H12N2O4
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eMolecules 2226789-82-6 | Medchem Express | UNC5293 | 5mg | 632433237 | HY-132200 | 518.706 | C30H42N6O2
Ambeed | 46-Dichloro-5-methoxypyrimidine | 10g | 552633648 | A192394 | 5018-38-2 | MFCD00087680 | 179.000 | C5H4Cl2N2O
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Apexbio Technology LLC Canagliflozin(Synonyms: Invokana, TA-7284, JNJ-28431754, Sulisent, Canagliflozin hemihydrate), 100mg, CAS: 842133-18-0.
Canagliflozin (CAS 842133-18-0) is a selective inhibitor of sodium-glucose cotransporter 2 (SGLT2) a transporter responsible for renal glucose reabsorption By inhibiting SGLT2 activity Canagliflozin decreases renal glucose reabsorption resulting in increased urinary glucose excretion In CHO cells expressing human rat or mouse SGLT2 Canagliflozin potently inhibits sodium-dependent glucose uptake with IC50 values of 4 4 3 7 and 2 0 nM respectively Animal studies using db/db mice and Zucker diabetic fatty (ZDF) rats demonstrate dose-dependent reductions in blood glucose as well as decreased respiratory exchange ratio and body weight Canagliflozin is suitable for in vivo research through oral administration
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Medchemexpress LLC C17H11Br2NO2S2 | 893449-38-2 | 99.1% | 485.21 | 10 MG
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PRL-3 Inhibitor I is a potent PRL-3 inhibitor with an IC50 of 0.9 μM. It demonstrates reduced invasion in cell-based assays.
- Potent PRL-3 inhibitor with an IC50 of 0.9 μM.
- Reduces invasion in cell-based assay.
- For research use only.
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Enzo Life Sciences Gefitinib-based PROTAC 3 (5mg). CAS: 2230821-27-7
Gefitinib-based PROTAC 3 is targeting on EGFR, consisting of Gefitinib as the warhead linked to VHL-recruiting ligand. Purity: ≥99%. Solubility: Soluble in DMSO (75 mg/mL). Insoluble in water. Long Term Storage: -20°C.
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Medchemexpress LLC EGFR-IN-17 5mg | 2817679-31-3 | 568.01 | C27H31ClN7O3P | 5 MG
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EGFR-IN-17 is a potent, selective small-molecule inhibitor of the epidermal growth factor receptor (EGFR) developed to overcome C797S-mediated resistance in mutant EGFR variants. It is intended for research use only and is supplied as a solid or as a DMSO solution for in vitro studies.
- Potent EGFR inhibition (IC50 0.0002 μM).
- Active against C797S, T790M, and L858R EGFR mutants.
- Molecular formula C27H31ClN7O3P and molecular weight 568.01.
- High purity (98.18%) and off-white to light yellow solid.
- Available as small solid quantities (e.g., 5 MG) and as 10 mM solution in DMSO.
- Soluble in DMSO (12.5 mg/mL); ultrasonic warming may be required.
- Recommended storage: powder at -20 °C (up to 3 years); in solvent at -80 °C for long-term.
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Strem, An Ascensus Company Trityltetra(PFP)borate, 97% 5g
CAS# 136040-19-2. 5g. Trityltetra(pentafluorophenyl)borate, min. 97%. MFCD03426981. Molecular Weight: 922.40. Molecular Formula: (C6H5)3C+(C6F5)4Bae. Color/form: yellow pwdr. Strem# 05-5000. http://www.strem.com/catalog/v/05-5000/
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eMolecules 1629229-37-3 | Medchem Express | Fezolinetant | 1mg | 446270036 | HY-19632 | 358.4 | C16H15FN6OS
Ambeed | Benzo[h]quinoline | 1g | 525075070 | A160237 | 230-27-3 | MFCD00004984 | 179.222 | C13H9N
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![Medchemexpress LLC 8-(4-chlorophenyl)-6-(2-methyl-2H-indazol-5-yl)-2-[(2,2,2-trifluoroethyl)amino]pyrido[4,3-d]pyrimidin-7(6H)-one | 2377491-54-6 | 99.5% | 484.86 | C23H16ClF3N6O | 5 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000221684.png-250.jpg)
Medchemexpress LLC 8-(4-chlorophenyl)-6-(2-methyl-2H-indazol-5-yl)-2-[(2,2,2-trifluoroethyl)amino]pyrido[4,3-d]pyrimidin-7(6H)-one | 2377491-54-6 | 99.5% | 484.86 | C23H16ClF3N6O | 5 MG
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AGI-43192 is a potent small-molecule inhibitor of methionine adenosyltransferase 2A (MAT2A). It is orally active with limited blood-brain barrier penetration and is supplied as a light yellow solid for research use in biochemical and pharmacological studies.
- Potent MAT2A inhibition shown in biochemical assays.
- Orally active pharmacokinetic profile suitable for in vivo studies.
- Limited blood-brain barrier penetration for peripheral target engagement.
- High purity for reliable experimental results.
- Soluble in DMSO and compatible with published in vivo formulations.
- Stable under recommended storage conditions (powder -20°C).
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Medchemexpress LLC VEGFR-2-IN-5 hydrochloride | 1430089-64-7 | 364.45 | 5 MG
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VEGFR-2-IN-5 is a VEGFR2 inhibitor extracted from patent WO2013055780A1, Page 69. At equivalent molar concentrations, both the salt and free forms of a compound exhibit comparable biological activity. Nevertheless, the salt form (VEGFR-2-IN-5 hydrochloride) usually boasts enhanced water solubility and stability. It is for research use only and not sold to patients.
- VEGFR2 inhibitor.
- The salt form offers enhanced water solubility and stability compared to the free form.
- For research use only.
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Medchemexpress LLC HY-111540B 10mg Medchemexpress, (S)-IDO1-IN-5 CAS:2166616-76-6 Purity:>98%
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Medchemexpress, HY-111540B 10mg (S)-IDO1-IN-5 CAS:2166616-76-6 (S)-IDO1-IN-5 (Example 1B) is an active S-isomer of IDO1-IN-5. (S)-IDO1-IN-5 binds to IDOL with an IC50 value less than 1.5 µΜ. IDO1-IN-5 is a potent, selective and brain penetrated inhibitor of Indoleamine 2,3-Dioxygenase 1 (IDO1) activity, binds to apo-IDO1 lacking heme rather than mature heme-bound IDO1. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
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![eMolecules 493024-40-1 | 4-[5-(4-Fluorophenyl)-1,3,4-oxadiazol-2-yl]piperidine | Combi-Blocks | MFCD03424488 | 247.273 | C13H14FN3O | 95.000 | Fc1ccc(cc1)-c1nnc(o1)C1CCNCC1 | 1g | 517033964](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502185836.JPG-250.jpg)
eMolecules 493024-40-1 | 4-[5-(4-Fluorophenyl)-1,3,4-oxadiazol-2-yl]piperidine | Combi-Blocks | MFCD03424488 | 247.273 | C13H14FN3O | 95.000 | Fc1ccc(cc1)-c1nnc(o1)C1CCNCC1 | 1g | 517033964
4-[5-(4-Fluorophenyl)-1,3,4-oxadiazol-2-yl]piperidine | Combi-Blocks | 493024-40-1 | MFCD03424488 | 247.273 | C13H14FN3O | 95.000 | Fc1ccc(cc1)-c1nnc(o1)C1CCNCC1 | 1g | 517033964
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Medchemexpress LLC N-acetyl-phenylalanyl-lysyl-prolyl-leucyl-alanyl-alanyl-alanyl-arginine | 2891606-02-1 | 99.8% | C43H70N12O10 | 10MG
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BM213 is a selective C5a receptor 1 (C5aR1) agonist peptide used in research to activate complement signaling, promote neutrophil extracellular trap formation, increase reactive oxygen species, and induce cardiomyocyte apoptosis; it is employed as a tool compound in myocardial ischemia/reperfusion injury studies.
- Selective C5aR1 agonist with an EC50 of 59 nM.
- Peptide sequence Ac-Phe-Lys-Pro-Leu-Ala-Ala-Ala-Arg (Ac-FKPLAAAR).
- High reported purity (99.8%).
- Molecular formula C43H70N12O10 and molecular weight 915.09.
- Storage: protect from light and store under nitrogen; in solvent: -80°C (6 months) or -20°C (1 month).
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Medchemexpress LLC BCATc Inhibitor 2 10mg | 406191-34-2 | 418.77 g/mol | C16H10ClF3N2O4S | 10 MG
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BCATc Inhibitor 2 is a selective inhibitor of cytosolic branched-chain aminotransferase (BCATc/BCAT1) used as a research tool in studies of branched-chain amino acid metabolism and neurodegenerative disease mechanisms. Reported IC50 values include 0.2 μM (rat cytosolic rBCATc), 0.8 μM (human cytosolic hBCATc), and 3.0 μM (rat mitochondrial rBCATm). The compound is supplied in high-purity solid and DMSO solution formats for laboratory research.
- Selective inhibitor of cytosolic branched-chain aminotransferase (BCATc).
- Reported IC50s: 0.2 μM (rBCATc), 0.8 μM (hBCATc), 3.0 μM (rBCATm).
- High purity (99.28%).
- Molecular formula C16H10ClF3N2O4S; molecular weight 418.77 g/mol.
- Suitable for in vitro biochemical and cell-based assays.
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