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Filtered Search Results
Medchemexpress LLC MD2-TLR4-IN-1 | 2249801-12-3 | 98.2% | 10 MG
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MD2-TLR4-IN-1 is a myeloid differentiation protein 2/toll-like receptor 4 (MD2-TLR4) complex antagonist. It inhibits Lipopolysaccharides (LPS)-induced expression of TNF-α and IL-6 in macrophages with IC50 values of 0.89 μM and 0.53 μM, respectively. This compound can be utilized for the study of acute lung injury (ALI).
- Exerts anti-inflammatory activity by inhibiting NF-κB in RAW264.7 macrophages.
- Directly binds to the MD2-TLR4 complex and disrupts MD2-TLR4 activation.
- Suppresses NF-κB p65 subunit nuclear levels in LPS-induced macrophages.
- Significantly inhibits macrophage infiltration and ameliorates histopathological changes in lung tissues.
- Effectively reduces airspace inflammation and amends pulmonary lobule tissue structure.
- Decreases LPS-induced myeloperoxidase (MPO) activity and serum TNF-α levels.
- Reduces mRNA levels of TNF-α, IL-6, IL-1β, IL-12, IL-33, and COX-2 in lung tissues.
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Sigma Aldrich Fine Chemicals Biosciences Pirodavir >=98% (HPLC) | 124436-59-5 | MFCD00866965 | 25MG
Pirodavir >=98% (HPLC) | Purity: >=98% (HPLC) | Mol Wt: 369.46 | 124436-59-5 | MFCD00866965 | 25MG
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![eMolecules 128249-70-7 | 2,6-Bis((R)-4-phenyl-4,5-dihydrooxazol-2-yl)pyridine | Ambeed369.424 | C23H19N3O2 | 98.000 | C1OC(=N[C@@H]1c1ccccc1)c1cccc(n1)C1=N[C@@H](CO1)c1ccccc1 | 100mg | 525196869](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502425075.PNG-250.jpg)
eMolecules 128249-70-7 | 2,6-Bis((R)-4-phenyl-4,5-dihydrooxazol-2-yl)pyridine | Ambeed369.424 | C23H19N3O2 | 98.000 | C1OC(=N[C@@H]1c1ccccc1)c1cccc(n1)C1=N[C@@H](CO1)c1ccccc1 | 100mg | 525196869
2,6-Bis((R)-4-phenyl-4,5-dihydrooxazol-2-yl)pyridine | Ambeed | 128249-70-7369.424 | C23H19N3O2 | 98.000 | C1OC(=N[C@@H]1c1ccccc1)c1cccc(n1)C1=N[C@@H](CO1)c1ccccc1 | 100mg | 525196869
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Active Motif CTPB
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Active Motif's A selective activator of p300 HAT (histone acetyltransferase). Selective over PCAF (p300 CPB-associated factor).
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Medchemexpress LLC MD2-TLR4-IN-1 | 2249801-12-3 | 98.2% | 100 MG
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MD2-TLR4-IN-1 is an antagonist of the myeloid differentiation protein 2/toll-like receptor 4 (MD2-TLR4) complex. It inhibits Lipopolysaccharides (LPS)-induced expression of TNF-α and IL-6 in macrophages. This product is suitable for research related to acute lung injury (ALI).
- Inhibits NF-κB in RAW264.7 macrophages
- Directly binds to the MD2-TLR4 complex and disrupts its activation
- Suppresses NF-κB p65 subunit nuclear levels in LPS-induced macrophages
- Significantly inhibits dimerization of the MD2-TLR4 complex in LPS-activated mouse primary macrophages (MPMs)
- Reduces airspace inflammation and ameliorates histopathological changes in lung tissues of LPS-challenged mice
- Decreases LPS-induced myeloperoxidase (MPO) activity and serum TNF-α levels
- Lowers mRNA levels of TNF-α, IL-6, IL-1β, IL-12, IL-33, and COX-2 in lung tissues
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Medchemexpress LLC Tucatinib hemiethanolate | 1429755-56-5 | 100.0% | 503.57 g·mol⁻¹ | C26H24N8O2 · 1/2 C2H6O | 10 MG
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Tucatinib hemiethanolate is a research-grade small molecule that potently and selectively inhibits HER2 (reported IC50 8 nM). It is supplied as the hemiethanolate salt for analytical and research applications and is not for human therapeutic use.
- Potent HER2 inhibition (IC50 8 nM).
- Selective activity for HER2, supporting targeted research applications.
- High purity suitable for analytical and in vitro studies.
- Available in small research-scale quantities, such as 10 mg.
- Provided with batch-specific certificate of analysis for traceability.
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eMolecules 1435488-37-1 | XMD17-109 | MFCD26142929 | 50mg
Medchem Express | Fenoterol (hydrobromide) | 100mg | 518571288 | HY-B0976A | 1944-12-3 | MFCD00079288 | 384.270 | C17H22BrNO4
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Sigma Aldrich Fine Chemicals Biosciences 14 Dimethoxybenzene 99 fG
1 4-Dimethoxybenzene can be used as a flavoring agent in the food industry. It s one of the main volatile constituents identified inTuber brumale Vietnamese green tea and lotus tea.
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Medchemexpress LLC IBT6A | 1022150-12-4 | 99.6% | 500 MG
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IBT6A is identified as an impurity of Ibrutinib and can be utilized in the synthesis of IBT6A Ibrutinib dimer and IBT6A adduct. Ibrutinib is a selective, irreversible Btk inhibitor. IBT6A can also be used in the synthesis of Ibrutinib and Ibrutinib-based activity-based probes (ABPs).
- Impurity of Ibrutinib
- Used in synthesis of Ibrutinib dimer and adduct
- Related to a selective, irreversible Btk inhibitor
- Utilized in synthesis of Ibrutinib and Ibrutinib-based activity-based probes (ABPs)
- Available as a white to yellow solid
- Molecular weight of 386.45
- Chemical formula is C22H22N6O
- Soluble in DMSO at 50 mg/mL (129.38 mM)
- Intended for research use only
- Long-term storage at -20°C for powder, -80°C for solvent
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Medchemexpress LLC AMG-548 | 864249-60-5 | MFCD26792556 | 98.3% | 461.6 g/mol | C29H27N5O | 5 MG
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AMG-548 | 864249-60-5 | MFCD26792556 | 98.3% | 461.6 g/mol | C29H27N5O | 5 MG
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eMolecules 173334-57-1 | Aliskiren | MFCD09839018 | 50mg
Medchem Express | ICAM-1-IN-1 | 5mg | 446276030 | HY-U00003 | 251994-14-6 | 363.230 | C15H11BrN2O2S
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Medchemexpress LLC AMG 579 | 1227067-61-9 | 99.0% | 10 MG
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AMG 579 is a potent, selective, and efficacious inhibitor of phosphodiesterase 10A (PDE10A) with an IC50 of 0.1 nM. It has shown a statistically significant reduction of PCP induced behavior in rats.
- Potent, selective, and efficacious inhibitor of phosphodiesterase 10A (PDE10A)
- IC50 of 0.1 nM for phosphodiesterase 10A
- Statistically significant reduction of PCP induced behavior in rats
- Minimum effective dose of 0.3 mg/kg for efficacy in PCP-LMA model
- Exhibits a superior oral bioavailability of 72% in dogs
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Medchemexpress LLC HY-18256 5mg Medchemexpress, Ombrabulin (hydrochloride) CAS:253426-24-3 Purity:>98%
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Medchemexpress, HY-18256 5mg Ombrabulin (hydrochloride) CAS:253426-24-3 Ombrabulin hydrochloride is a derivative of CA-4 phosphate, which is known to exhibit antivascular effects through selective disruption of the tubulin cytoskeleton of endothelial cells. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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502082352 AZASETRON HYDROCHLO 10MG
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Medchemexpress LLC HY-10917 1g , GW2580 CAS:870483-87-7 Purity:98%
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Medchemexpress, HY-10917 1g GW2580 CAS:870483-87-7 Formula:C20H22N4O3 IC50: 30 nM (c-FMS) Purity:98% GW2580 is a selective CSF-1R inhibitor for c-FMS with IC 50 of 30 nM, and shows 150- to 500-fold selective compared to b-Raf, CDK4, c-KIT, c-SRC, EGFR, ERBB2/4, ERK2, FLT-3, GSK3, ITK, JAK2, etc. Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
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