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Filtered Search Results
Medchemexpress LLC Prexasertib (dimesylate) | 1234015-58-7 | 98.9% | 557.60 | 5 MG
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Prexasertib dimesylate is a selective, ATP-competitive second-generation checkpoint kinase 1 (CHK1) inhibitor with a Ki of 0.9 nM and an IC50 of <1 nM. It also inhibits CHK2 (IC50=8 nM) and RSK1 (IC50=9 nM). This compound induces double-stranded DNA breakage and replication catastrophe, leading to apoptosis, and demonstrates potent anti-tumor activity.
- Selective, ATP-competitive CHK1 inhibitor
- Inhibits CHK1 (Ki 0.9 nM, IC50 <1 nM), CHK2, and RSK1
- Induces double-stranded DNA breakage and replication catastrophe
- Leads to apoptosis and potent anti-tumor activity
- Inhibits MELK, SIK, BRSK2, and ARK5
- Requires CDC25A and CDK2 for DNA damage
- Causes DNA damage during S-phase
- Inhibits CHK1 and CHK2 autophosphorylation
- Induces cell-cycle shift with H2AX phosphorylation
- Triggers chromosomal fragmentation and replication stress
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eMolecules Medchem Express / LY341495 / 5mg / 446271395 / HY-70059 / / 201943-63-7 / MFCD00949707 / 353.374 / C20H19NO5
Medchem Express / LY341495 / 5mg / 446271395 / HY-70059 / / 201943-63-7 / MFCD00949707 / 353.374 / C20H19NO5
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MEDCHEMEXPRESS LLC BAY-598 5MG
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501873741 BAY-598 5MG
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MEDCHEMEXPRESS LLC SBI-0206965 5MG
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501873527 SBI-0206965 5MG
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Chem-Impex International, Inc. o-Phenyl chlorothiocarbonate | MFCD00004920 | 25G
o-Phenyl chlorothiocarbonate, MFCD00004920, 25G
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MEDCHEMEXPRESS LLC PFI-4 5MG
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501873670 PFI-4 5MG
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Medchemexpress LLC HY-16046 10mg Medchemexpress, Rimiducid CAS:195514-63-7 Purity:>98%
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Medchemexpress, HY-16046 10mg Rimiducid CAS:195514-63-7 Rimiducid (AP1903) is a dimerizer agent that acts by cross-linking the FKBP domains. Rimiducid (AP1903) dimerizes the Caspase 9 suicide switch and rapidly induces apoptosis. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
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eMolecules Medchem Express / VU 0238429 / 5mg / 446260776 / HY-12157 / / 1160247-92-6 / MFCD16618396 / 351.281 / C17H12F3NO4
Medchem Express / VU 0238429 / 5mg / 446260776 / HY-12157 / / 1160247-92-6 / MFCD16618396 / 351.281 / C17H12F3NO4
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MEDCHEMEXPRESS LLC MAYTANSINOL 5MG
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501873734 MAYTANSINOL 5MG
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MEDCHEMEXPRESS LLC D-64131 10MG
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501873253 D-64131 10MG
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eMolecules Bromodichloronitromethane | 918-01-4 | MFCD06795111 | 100mg
Toronto Research Chemicals | Bromodichloronitromethane | 100mg | 601591383 | B683425 | | 918-01-4 | MFCD06795111 | 208.820 | CBrCl2NO2
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000378998 MAO-B-IN-2 50MG
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Medchemexpress LLC HY-114157 5mg Medchemexpress, DO-264 CAS:2301866-59-9 Purity:>98%
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Medchemexpress, HY-114157 5mg DO-264 CAS:2301866-59-9 DO-264 is a selective and in vivo-active inhibitor of Abhydrolase Domain Containing 12 ( ABHD12 ), with an IC 50 of 11 nM. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
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Medchemexpress LLC GW6471 | 880635-03-0 | C35H36F3N3O4 | 100 MG
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GW6471 is a potent PPARα antagonist that inhibits GW409544-induced activation of PPARα with an IC50 of 0.24 μM. It significantly inhibits cell viability in Caki-1 and 786-O renal cell carcinoma cell lines in vitro. In vivo studies demonstrate its antitumor activity, showing decreased tumor growth and c-Myc levels in xenograft mouse models without observed toxicity.
- Potent PPARα antagonist
- Inhibits cell viability in renal cell carcinoma cell lines
- Demonstrates antitumor activity in vivo
- No toxicity observed at effective doses in animal studies
- Cited in numerous publications, including Nat Metab, Cell Metab, and Immunity
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Medchemexpress LLC AMG 900 5MG
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AMG 900, 5mg
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