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Filtered Search Results
Medchemexpress LLC HY-B0290A 100mg Medchemexpress, Pranlukast (hemihydrate) CAS:150821-03-7 Purity:>98%
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Medchemexpress, HY-B0290A 100mg Pranlukast (hemihydrate) CAS:150821-03-7 Pranlukast hemihydrate is a highly potent, selective and competitive antagonist of peptide leukotrienes. Pranlukast inhibits [3H]LTE4, [3H]LTD4, and [3H]LTC4 bindings to lung membranes with Kis of 0.63±0.11, 0.99±0.19, and 5640±680 nM, respectively. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
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Medchemexpress LLC (+)-Schisandrin B | 82467-52-5 | 5 MG
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(+)-Schisandrin B is an enantiomer of Schisandrin B, an active dibenzocyclooctadiene derivative isolated from the fruit of Schisandra chinensis. It exhibits an antioxidant effect on rodent liver and heart.
- Purity: 99.56%
- Molecular weight: 400.46
- Formula: C23H28O6
- Appearance: Solid
- Color: White to off-white
- Structure classification: Phenylpropanoids, Lignans
- Initial source: Plants, Schisandraceae, Schisandra chinensis (Turcz.) Baill.
- Storage: 4°C, protect from light. In solvent: -80°C, 6 months; -20°C, 1 month (protect from light)
- Solubility in DMSO: 25 mg/mL (62.43 mM)
- Intended for research use only
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Medchemexpress LLC FR194738 FR BS10MM 1ML SOLN
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MedChemExpress | FR194738 free base | 10 mM * 1 mL in DMSO Solution | HY-100303 10 mM * 1 mL in DMSO | Purity: 99.79% | 204067-45-8 | MW: 439.65
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Medchemexpress LLC AMG 579 | 1227067-61-9 | 99.0% | 50 MG
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AMG 579 is a potent, selective, and efficacious inhibitor of phosphodiesterase 10A (PDE10A) with an IC50 of 0.1 nM. It is intended for research use only. In vivo, AMG 579 has shown a statistically significant reduction of PCP-induced behavior in rats over a 2-hour period, with a minimum effective dose for efficacy in the PCP-LMA model determined to be 0.3 mg/kg. In dogs, it exhibits a superior oral bioavailability of 72%. One clinical trial (NCT01568203) is listed, sponsored by Amgen for Schizophrenia, with a start date of 2011-09, and it is in Phase 1.
- Potent, selective, and efficacious PDE10A inhibitor
- Demonstrates in vivo efficacy in reducing PCP-induced behavior in rats
- Exhibits superior oral bioavailability in dogs
- Underwent early-phase clinical trials for Schizophrenia
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Medchemexpress LLC 10-methyl-9-(phenoxycarbonyl) acridinium trifluoromethanesulfonate | 161006-14-0 | MFCD01320487 | 99.4% | 463.43 | C22H16F3NO5S | 5 MG
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10-Methyl-9-(phenoxycarbonyl) acridinium trifluoromethanesulfonate is an acridinium-based chemiluminescent reagent used in chemiluminescent assays for sensitive detection of enzymes, antigens, antibodies, and hormones. It converts to a fluorescent acridone upon oxidation and is supplied in small quantities for research and assay development.
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Medchemexpress LLC HY-120056 10mg Medchemexpress, YKL-06-061 CAS:2172617-15-9 Purity:>98%
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Medchemexpress, HY-120056 10mg YKL-06-061 CAS:2172617-15-9 YKL-06-061 is a potent, selective, second-generation salt-inducible kinase (SIK) inhibitor with IC50 values of 6.56 nM/1.77 nM/20.5 nM for SIK1/2/3, respectively. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
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Medchemexpress LLC HY-18932 5mg Medchemexpress, DEL-22379 CAS:181223-80-3 Purity:>98%
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Medchemexpress, HY-18932 5mg DEL-22379 CAS:181223-80-3 DEL-22379 is an ERK dimerization Inhibitor. DEL-22379 readily binds to ERK2 with a Kd estimated in the low micromolar range, though binding is detectable even at low nanomolar concentrations. ERK2 dimerization is progressively inhibited with an IC50 of ~0.5 μM. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
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Medchemexpress LLC Berotralstat | 10 MG
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Berotralstat | 10 MG
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Medchemexpress LLC CM-579 trihydrochloride | 2448471-08-5 | 97.0% | 602.04 g/mol | C29H43Cl3N4O3 | 10 MG
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CM-579 trihydrochloride is a reversible, dual inhibitor of histone methyltransferase G9a and DNA methyltransferases (DNMT) with potent in vitro activity in cancer cell lines. It is supplied as a research reagent for biochemical and cellular studies and is for research use only.
- Reversible dual inhibition of G9a and DNMT.
- Low nanomolar potency (IC50 ≈ 16 nM for G9a, ≈ 32 nM for DNMT).
- High reported purity (97.0%).
- Supplied in a small-mass vial suitable for biochemical and cellular assays.
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Medchemexpress LLC HY-13455A 5mg Medchemexpress, LDN-192960 (hydrochloride) CAS:2309172-48-1 Purity:>98%
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Medchemexpress, HY-13455A 5mg LDN-192960 (HCl) CAS:2309172-48-1 LDN-192960 hydrochloride is an inhibitor of Haspin and Dual-specificity Tyrosine-regulated Kinase 2 (DYRK2) with IC50s of 10 nM and 48 nM, respectively. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
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Medchemexpress LLC HY-112613 10mg Medchemexpress, UCB9608 CAS:1616413-96-7 Purity:>98%
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Medchemexpress, HY-112613 10mg UCB9608 CAS:1616413-96-7 UCB9608 is a potent, selective and orally active PI4KIIIβ inhibitor, with an IC50 of 11 nM, selective over PI3KC2 α, β, and γ lipid kinases. UCB9608 improves metabolic stability and exhibits excellent pharmacokinetic profile, acts as a potent immunosuppressive agent. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
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Medchemexpress LLC Tivozanib hydrochloride hydrate | 682745-41-1 | 99.8% | 509.34 | 10 MM 1 ML
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Tivozanib hydrochloride hydrate is the hydrate hydrochloride form of Tivozanib. It is a selective, orally active inhibitor for vascular endothelial growth factor receptor (VEGFR)-1, 2, and 3. This compound exhibits antitumor efficacy.
- Selective, orally active inhibitor for VEGFR-1, 2, and 3
- Exhibits antitumor efficacy
- Available in solid form, white to off-white color
- Soluble in DMSO (125 mg/mL)
- Inhibits the phosphorylation of VEGFR-1, VEGFR-2, and VEGFR-3
- Inhibits VEGF-induced proliferation and migration of HUVECs
- Selectively inhibits VEGF-stimulated phosphorylation of MAPKs in endothelial cells
- Exhibits antitumor efficacy against various cancers in athymic mice models
- Reversibly suppresses vascular permeability and angiogenesis in tumor-bearing rats
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Medchemexpress LLC Mesdopetam hemitartrate | 2562346-14-7 | 99.86% | 350.39 | 50 MG
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Mesdopetam (IRL790) hemitartrate is a dopamine D3 receptor antagonist with psychomotor stabilizing properties, exhibiting a Ki of 90 nM and an IC50 of 9.8 μM for the human recombinant D3 receptor. It is utilized in research for motor and psychiatric complications associated with Parkinson disease.
- Dopamine D3 receptor antagonist
- Psychomotor stabilizing properties
- Used for research of motor and psychiatric complications in Parkinson disease
- Exhibits a Purity of 99.86%
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Medchemexpress LLC HY-101354 5mg Medchemexpress, R-IMPP CAS:2133832-83-2 Purity:>98%
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Medchemexpress, HY-101354 5mg R-IMPP CAS:2133832-83-2 R-IMPP is an anti-secretagogue of PCSK9 (IC50=4.8 μM), which targets the 80S ribosome to inhibit PCSK9 protein translation. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
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Medchemexpress LLC HY-102014 5mg Medchemexpress, RN-18 CAS:431980-38-0 Purity:>98%
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Medchemexpress, HY-102014 5mg RN-18 CAS:431980-38-0 RN-18 is a HIV-1 viral infectivity factor (HIV-1 Vif) inhibitor with an IC50 of 6 μM in nonpermissive H9 cells. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
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