Phenylhydrazines
Medchemexpress LLC Pyridostatin hydrochloride | 1781882-65-2 | C31H37Cl5N8O5 | 5 MG
Pyridostatin hydrochloride is a G-quadruplex DNA stabilizing agent that targets DNA and RNA G4s in cells. It promotes growth arrest in human cancer cells by inducing replication- and transcription-dependent DNA damage. This selective G-quadruplex DNA-binding small molecule also targets the proto-oncogene Src, reducing SRC protein levels and cellular motility in human breast cancer cells.
- G-quadruplex DNA stabilizing agent (Kd=490 nM)
- Targets DNA and RNA G4s in cells
- Promotes growth arrest in human cancer cells
- Induces replication- and transcription-dependent DNA damage
- Targets proto-oncogene Src
- Reduces SRC protein levels and cellular motility
- Causes neurite retraction, synaptic loss, and neuronal death
- Induces formation of DNA DSBs
- Downregulates BRCA1 protein at transcriptional level
Medchemexpress LLC 2-Methyl-1,2,5,6-tetrahydro-3H-pyrrolo[3,2,1-ij]quinazolin-3-imine hydrochloride | C11H14ClN3 | 5 MG
JBSNF-000028 hydrochloride is an orally active, small molecule inhibitor of tricyclic nicotinamide N-methyltransferase (NNMT) with IC50 values of 33 nM for human NNMT. It effectively reduces endogenous MNA levels in U2OS osteosarcoma cells with an EC50 of 2.5 μM. This compound has demonstrated significant anti-obesity and anti-diabetic activities in diet-induced obesity models.
- Inhibits NNMT activity with an EC50 of 2.5 μM in U2OS cells
- Shows no cytotoxicity against HepG2 cells at 10-100 μM
- Improves glucose and lipid handling in mice with diet-induced obesity
- Improves glucose tolerance in NNMT knockout mice with diet-induced obesity
- Used for studying metabolic diseases such as obesity, type 2 diabetes, and non-alcoholic fatty liver disease
Aobchem 4-(Hydroxymethyl)-2-methylphenylboronic acid | ≥97% | CAS 166386-66-9 | C8H11BO3 | 1g
4-(Hydroxymethyl)-2-methylphenylboronic acid | ≥97% | CAS 166386-66-9 | C8H11BO3 | 1g
Aobchem 4-Chloro-2-fluoro-5-methylphenylboronic acid | ≥97% | CAS 325786-09-2 | C7H7BClFO2 | 250mg
4-Chloro-2-fluoro-5-methylphenylboronic acid | ≥97% | CAS 325786-09-2 | C7H7BClFO2 | 250mg
Aobchem 3-(Difluoromethoxy)benzaldehyde | ≥97% | CAS 85684-61-3 | C8H6F2O2 | 10g
3-(Difluoromethoxy)benzaldehyde | ≥97% | CAS 85684-61-3 | C8H6F2O2 | 10g
Aobchem 4-Chloro-2-fluoro-3-methylphenylboronic acid | ≥97% | CAS 944128-92-1 | C7H7BClFO2 | 1g
4-Chloro-2-fluoro-3-methylphenylboronic acid | ≥97% | CAS 944128-92-1 | C7H7BClFO2 | 1g
Medchemexpress LLC Besifloxacin hydrochloride | 405165-61-9 | 98.5% | 430.30 | 5 MG
Besifloxacin Hydrochloride is a fourth generation fluoroquinolone antibiotic. It functions as a DNA gyrase and topoisomerase IV inhibitor. This compound demonstrates broad-spectrum antibacterial activity against Gram-negative and Gram-positive aerobic and anaerobic strains, and it helps reduce the incidence of drug resistance. Additionally, Besifloxacin Hydrochloride exhibits anti-inflammatory activity and is suitable for bacterial conjunctivitis research.
- Fourth generation fluoroquinolone antibiotic.
- DNA gyrase and topoisomerase IV inhibitor.
- Broad-spectrum antibacterial activity against Gram-negative and Gram-positive aerobic and anaerobic strains.
- Reduces the incidence of drug resistance.
- Anti-inflammatory activity.
- Used in bacterial conjunctivitis research.
Aobchem (3-Bromo-2-fluoro-5-methylphenyl)(piperidin-1-yl)methanone | 95% | CAS 2918897-70-6 | C13H15BrFNO | 5g
(3-Bromo-2-fluoro-5-methylphenyl)(piperidin-1-yl)methanone | 95% | CAS 2918897-70-6 | C13H15BrFNO | 5g
Aobchem (3-Bromo-2-fluoro-5-methylphenyl)(piperidin-1-yl)methanone | 95% | CAS 2918897-70-6 | C13H15BrFNO | 500mg
(3-Bromo-2-fluoro-5-methylphenyl)(piperidin-1-yl)methanone | 95% | CAS 2918897-70-6 | C13H15BrFNO | 500mg
Medchemexpress LLC Triprolidine hydrochloride | 550-70-9 | MFCD00039044 | 99.8% | 5 MG
Triprolidine hydrochloride is an orally active histamine H1 antagonist. It functions as a spinal cord motor and sensory block and is used for research related to allergic rhinitis.
- Orally active histamine H1 antagonist
- Functions as a spinal cord motor and sensory block
- Used in research for allergic rhinitis
Aobchem 3-(1-Methylethenyl)benzaldehyde | 97% | CAS 123926-80-7 | C10H10O | 250mg
3-(1-Methylethenyl)benzaldehyde | 97% | CAS 123926-80-7 | C10H10O | 250mg
Medchemexpress LLC Ethopropazine hydrochloride | 1094-08-2 | MFCD00012653 | 99.3% | 348.93 | C19H25ClN2S | 1 ML
Ethopropazine hydrochloride is a research-grade anticholinergic compound used in neuroscience and pharmacology studies. It functions primarily as a butyrylcholinesterase inhibitor, with weaker activity against acetylcholinesterase, and exhibits non-selective muscarinic and NMDA receptor antagonism. The compound is used for investigations of cholinergic signaling and in Parkinson's disease models, and is supplied in formats suitable for in vitro dosing and analytical work.
- Potent butyrylcholinesterase (BChE) inhibitor.
- Weak acetylcholinesterase (AChE) activity for selectivity studies.
- Non-selective muscarinic and NMDA receptor antagonism.
- Suitable for Parkinson's disease and neuropharmacology research.
- Available as solid or pre-made 10 mM solution for easy dosing.
- Documented stability and storage guidelines for reproducible results.
Medchemexpress LLC Levofloxacin (hydrochloride) | 177325-13-2 | 99.0% | 5 G
Levofloxacin hydrochloride is an orally active antibiotic that inhibits DNA gyrase and topoisomerase IV activity, inducing apoptosis. It demonstrates broad-spectrum antibacterial activity against both Gram-positive and Gram-negative bacteria, and has shown anticancer activity against lung cancer. This compound also exhibits anti-acnegenic, anxiogenic, and analgesic effects, and shortens sleep duration in mice, making it valuable for research into infectious diseases and lung cancer.
- Orally active antibiotic
- Inhibits DNA gyrase and topoisomerase IV activity
- Induces apoptosis
- Active against Gram-positive and Gram-negative bacteria
- Exhibits anticancer activity against lung cancer
- Possesses anti-acnegenic, anxiogenic, and analgesic effects
- Shortens sleep duration in mice
- Used in infectious diseases and lung cancer research
Medchemexpress LLC Triprolidine (hydrochloride) | 550-70-9 | 25MG
Triprolidine hydrochloride is an orally active histamine H1 antagonist. It has the function of spinal cord motor and sensory block and can be used for the research of allergic rhinitis.
- Orally active histamine H1 antagonist.
- Exhibits spinal cord motor and sensory block function.
- Can antagonize histamine H1 and decrease the expression of CD45 in maturing human dendritic cells.
- Produces a dose-dependent effect of spinal motor and sensory block in rats when administered intrathecally.
Aobchem Ethyl 2-(2-chloro-5-methylphenyl)-2-oxoacetate | 95% | CAS 1824024-44-3 | C11H11ClO3 | 500mg
Ethyl 2-(2-chloro-5-methylphenyl)-2-oxoacetate | 95% | CAS 1824024-44-3 | C11H11ClO3 | 500mg