Phthalic acid and derivatives
Apexbio Technology LLC Cyclic somatostatin 38916-34-6 5mg
Cyclic somatostatin is a cyclic peptide neurohormone that targets somatostatin receptors It functions as an inhibitor of growth hormone secretion through interaction with these receptors thereby regulating neuroendocrine and cardiovascular pathways Cyclic somatostatin exerts its biological activity primarily by inhibiting isoproterenol-induced responses in ventricular myocytes and modulating myocardial contraction It is stored and co-released with acetylcholine from cardiac parasympathetic nerves Based on these pharmacological properties cyclic somatostatin holds research potential in studies of acute gastro-duodenal ulcer bleeding and in the investigation of receptor-mediated signaling pathways in cardiovascular and neuroendocrine systems Its defined molecular structure also enables its use as a reference standard in analytical assays
eMolecules MONOMETHYL-5-AMINO-ISOPHTHALATE | 28179-47-7 | MFCD00224870 | 5g
AstaTech | MONOMETHYL-5-AMINO-ISOPHTHALATE | 5g | 233616389 | 24682 | 95.000 | 28179-47-7 | MFCD00224870 | 195.174 | C9H9NO4
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Medchemexpress LLC Guanosine, cyclic 3',5'-(hydrogen phosphate) (TBAOH) | 99.1% | 604.68 | 10 MG
Cyclic GMP (cGMP) TBAOH is an important second messenger and a major intracellular mediator of extracellular signals like nitric oxide (NO) and natriuretic peptides (NPs). Its effects are mediated through cGMP-dependent protein kinases (PKGs), cGMP-gated cation channels, and PDEs. Cyclic GMP can inhibit platelet adhesion and aggregation. cGAMP (Cyclic-GMP-AMP), a conjugate of Cyclic GMP and AMP, can induce IRF3 phosphorylation and nuclear translocation, enhancing antiviral immune responses.
- Important second messenger
- Intracellular mediator of extracellular signals (nitric oxide and natriuretic peptides)
- Inhibits both platelet adhesion and aggregation
- Can activate cGMP-mediated protein kinases
- Can activate cGMP-stimulated phosphodiesterases when acting synergistically with Isoprenaline, reversing cAMP-mediated enhancement or inhibiting cAMP-induced inward calcium current (ICa)
Medchemexpress LLC Cyclic GMP (TBAOH) | 99.1% | 604.68 | 1 ML
Cyclic GMP (cGMP) TBAOH is an important second messenger and a major intracellular mediator of extracellular signals such as nitric oxide (NO) and natriuretic peptides (NPs). Its effects occur through three main groups of cellular targets: cGMP-dependent protein kinases (PKGs), cGMP-gated cation channels, and PDEs. Cyclic GMP can inhibit both platelet adhesion and aggregation. cGAMP (Cyclic-GMP-AMP), a conjugate of Cyclic GMP and AMP, can induce IRF3 phosphorylation and nuclear translocation, enhancing antiviral immune responses.
- Important second messenger
- Major intracellular mediator of extracellular signals such as nitric oxide (NO) and natriuretic peptides (NPs)
- Affects cGMP-dependent protein kinases (PKGs), cGMP-gated cation channels, and PDEs
- Can inhibit both platelet adhesion and aggregation
- A conjugate can enhance antiviral immune responses
Medchemexpress LLC Cyclic GMP sodium | 40732-48-7 | 99.9% | 367.19 | 25 MG
Cyclic GMP (cGMP) sodium is an important second messenger and a major intracellular mediator of extracellular signals like nitric oxide (NO) and natriuretic peptides (NPs). Its effects are mediated through three main groups of cellular targets: cGMP-dependent protein kinases (PKGs), cGMP-gated cation channels, and phosphodiesterases (PDEs). It can inhibit both platelet adhesion and aggregation, and its conjugate, cGAMP, can enhance antiviral immune responses.
- Important second messenger.
- Major intracellular mediator of extracellular signals such as nitric oxide (NO) and natriuretic peptides (NPs).
- Mediates effects through cGMP-dependent protein kinases, cGMP-gated cation channels, and PDEs.
- Inhibits platelet adhesion and aggregation.
- Can enhance antiviral immune responses through its conjugate.
- Activates cGMP-stimulated phosphodiesterases synergistically with Isoprenaline.
Medchemexpress LLC Cyclic GMP | 7665-99-8 | 99.8% | 345.21 | 25 MG
Cyclic GMP (cGMP) is an important second messenger and a major intracellular mediator of extracellular signals such as nitric oxide (NO) and natriuretic peptides (NPs). Its effects are primarily through cGMP-dependent protein kinases (PKGs), cGMP-gated cation channels, and phosphodiesterases (PDEs). Cyclic GMP can also inhibit platelet adhesion and aggregation. cGAMP (Cyclic-GMP-AMP), a conjugate of Cyclic GMP and AMP, can induce IRF3 phosphorylation and nuclear translocation, thereby enhancing antiviral immune responses.
- Important second messenger.
- Major intracellular mediator of extracellular signals.
- Acts primarily through cGMP-dependent protein kinases, cGMP-gated cation channels, and phosphodiesterases.
- Can inhibit platelet adhesion and aggregation.
- Conjugate cGAMP can induce IRF3 phosphorylation and nuclear translocation.
- Enhances antiviral immune responses.
Medchemexpress LLC 8-CPT-Cyclic AMP sodium | 93882-12-3 | 99.7% | 493.79 | 10 MG
8-CPT-Cyclic AMP sodium is a selective activator of cyclic AMP-dependent protein kinase (PKA). It is also a potent inhibitor of the cyclic GMP-specific phosphodiesterase (PDE VA) with an IC50 of 0.9 μM. Additionally, 8-CPT-Cyclic AMP sodium inhibits PDE III and PDE IV with IC50 values of 5.5 μM and 6.6 μM, respectively, and is a potent Epac activator. It has been shown to delay TNF-α/CHX-induced and α-Fas-induced apoptosis in neutrophils.
- Selective activator of cyclic AMP-dependent protein kinase (PKA).
- Potent inhibitor of cyclic GMP-specific phosphodiesterase (PDE VA) with an IC50 of 0.9 μM.
- Inhibits PDE III and PDE IV with IC50 values of 5.5 μM and 6.6 μM.
- Potent Epac activator.
- Delays TNF-α/CHX-induced and α-Fas-induced apoptosis in neutrophils.
Medchemexpress LLC Dioctyl phthalate | 117-84-0 | 99.4% | 390.56 | 50 MG
Dioctyl phthalate (DNOP) is an active compound intended for research use only. This colorless to light yellow liquid has a high purity of 99.40% and a molecular weight of 390.56. It is crucial for various research applications.
- High purity (99.40%)
- Molecular weight of 390.56
- Appears as a colorless to light yellow liquid
- Suitable for research applications
- Store at room temperature, keep dry and cool
- Store in solvent at -80°C for 1 year or -20°C for 6 months
Medchemexpress LLC Cyclic AMP-13C5 (Cyclic adenosine monophosphate-13C5) | 2170095-23-3 | 97.5% | 1 MG
Cyclic AMP-13C5 is a deuterated cyclic AMP. This compound can be used as a tracer and as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS. Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
- Contains stable heavy isotopes.
Medchemexpress LLC Carbenoxolone disodium | 7421-40-1 | MFCD03840711 | 99.9% | 25 MG
Carbenoxolone disodium is the active metabolite of Glycyrrhizic acid and an inhibitor of human 11β-HSD and bacterial 3α, 20β-HSD. It functions as an uncoupling agent for gap junctions and is a potent inhibitor of Vaccinia virus replication. This product is used for research into peptic, esophageal, and oral ulceration and inflammation.
- Active metabolite of Glycyrrhizic acid.
- Inhibitor of human 11β-HSD and bacterial 3α, 20β-HSD.
- Uncoupling agent for gap junctions.
- Inhibitor of Vaccinia virus replication.
- Used for studying peptic, esophageal, and oral ulceration and inflammation.
Medchemexpress LLC Sulbenicillin disodium | 28002-18-8 | 50 MG
Sulbenicillin disodium is the disodium salt of Sulbenicillin. Sulbenicillin is a Penicillin antibiotic that exhibits antibacterial activity against various mucoid and non-mucoid strains of Pseudomonas aeruginosa.
- Purity: 98.84%
- Molecular Weight: 458.42
- Formula: C16H16N2Na2O7S2
- Appearance: Solid
- Color: White to off-white
- Storage: 4°C, sealed storage, away from moisture
- In-solvent storage: -80°C for 6 months or -20°C for 1 month, sealed and away from moisture
- Solubility in H2O: 250 mg/mL (requires sonication)
- Solubility in PBS: 100 mg/mL (clear solution; requires sonication)
Apexbio Technology LLC Disodium (R)-2-Hydroxyglutarate 103404-90-6 10mM (in 1mL H2O)
Disodium (R)-2-Hydroxyglutarate (CAS 103404-90-6) is an enantiomer of 2-hydroxyglutarate that functions as an inhibitor of ATP synthase a rotary enzyme complex critical for ATP production via oxidative phosphorylation Studies have shown that (R)-2-hydroxyglutarate accumulates in human cancers harboring IDH1 or IDH2 mutations where it suppresses ATP synthase activity leading to tumor cell growth arrest and cell death particularly under glucose-limited conditions In IDH-mutant glioma cells elevated (R)-2-hydroxyglutarate levels reduce oxygen consumption linked to ATP synthase This molecule is used to investigate metabolic vulnerabilities in malignancies with altered 2-hydroxyglutarate metabolism and the role of ATP synthase in cancer cell survival
Medchemexpress LLC Croconic acid disod 50mg
Croconic acid (disodium) (Nacr) can promote cell growth and proliferation by enhancing the expression of genes associated with lysine crotonylation (Kcr) modification Croconic acid holds potential for improving somatic cell nuclear transfer (SCNT) efficiency and optimizing cell culture conditions research[1]
Apexbio Technology LLC Disodium (R)-2-Hydroxyglutarate 103404-90-6 100mg
Disodium (R)-2-Hydroxyglutarate (CAS 103404-90-6) is an enantiomer of 2-hydroxyglutarate that functions as an inhibitor of ATP synthase a rotary enzyme complex critical for ATP production via oxidative phosphorylation Studies have shown that (R)-2-hydroxyglutarate accumulates in human cancers harboring IDH1 or IDH2 mutations where it suppresses ATP synthase activity leading to tumor cell growth arrest and cell death particularly under glucose-limited conditions In IDH-mutant glioma cells elevated (R)-2-hydroxyglutarate levels reduce oxygen consumption linked to ATP synthase This molecule is used to investigate metabolic vulnerabilities in malignancies with altered 2-hydroxyglutarate metabolism and the role of ATP synthase in cancer cell survival