Sulfanylbenzoic acids and derivatives
Medchemexpress LLC TAS-119 | 1453099-83-6 | 98.0% | 506.36 | 1 ML
TAS-119 is a potent, selective, and orally active Aurora A inhibitor. It demonstrates high selectivity for Aurora A over other protein kinases and exhibits potent antitumor activities.
- Potent and selective Aurora A inhibitor with an IC50 of 1.0 nM.
- Shows high selectivity for Aurora A over Aurora B (IC50 of 95 nM).
- Enhances the antiproliferative effect of paclitaxel in various human cancer cell lines, including paclitaxel-resistant cells.
- Dose-dependently enhances cell growth inhibition by taxanes.
- Induces mitotic accumulation predominantly in tumor cells.
Selleck Chemical LLC Anti-mouse Ter-119-InVivo
Anti-mouse Ter-119-InVivo reacts with mouse Ter-119 a 52 kDa glycophorin A-associated protein that is expressed by erythroid cells from the early proerythroblast stage to mature erythrocytes Anti-mouse Ter-119-InVivo is commonly used for identifying erythrocytes and cells in the erythroid lineage
Selleck Chemical LLC Anti-mouse Ter-119-InVivo
Anti-mouse Ter-119-InVivo reacts with mouse Ter-119 a 52 kDa glycophorin A-associated protein that is expressed by erythroid cells from the early proerythroblast stage to mature erythrocytes Anti-mouse Ter-119-InVivo is commonly used for identifying erythrocytes and cells in the erythroid lineage
Selleck Chemical LLC Anti-mouse Ter-119-InVivo-1MG
Anti-mouse Ter-119-InVivo reacts with mouse Ter-119 a 52 kDa glycophorin A-associated protein that is expressed by erythroid cells from the early proerythroblast stage to mature erythrocytes Anti-mouse Ter-119-InVivo is commonly used for identifying erythrocytes and cells in the erythroid lineage
Selleck Chemical LLC Anti-mouse Ter-119-InVivo-5MG
Anti-mouse Ter-119-InVivo reacts with mouse Ter-119 a 52 kDa glycophorin A-associated protein that is expressed by erythroid cells from the early proerythroblast stage to mature erythrocytes Anti-mouse Ter-119-InVivo is commonly used for identifying erythrocytes and cells in the erythroid lineage
Medchemexpress LLC Diuron | 330-54-1 | 99.1% | 500 MG
Diuron is an orally active phenylurea herbicide that inhibits photosynthesis in plants by blocking the formation of ATP and NADH. It promotes DMBA/BBN-induced bladder cancer and can be utilized in breast cancer research. It increases the production of reactive oxygen species (ROS) and the expression of p53 in certain cell lines. It exhibits herbicidal activity against annual and perennial broadleaf and grass weeds.
- Significantly increases ROS production in BeWo and MCF-7 cells
- Induces DNA damage in MCF-7 cells
- Inhibits *Allium cepa* root tip cell division and causes mitotic abnormalities
- Can induce urothelial hyperplasia in bladder and renal pelvis in Wistar rats
- Promotes bladder cancer occurrence in female Swiss mice
Medchemexpress LLC Anti-Mouse Ter-119 A 10mg | 10mg
Anti-Mouse Ter-119 Antibody (TER-119) is an anti-mouse Ter-119 IgG2b monoclonal antibody Anti-Mouse Ter-119 Antibody (TER-119) can increase platelet count Anti-Mouse Ter-119 Antibody (TER-119) can remove red blood cells and their precursor cells to isolate and enrich natural killer (NK) cells Anti-Mouse Ter-119 Antibody (TER-119) can be used for research on immune thrombocytopenia Anti-Mouse Ter-119 Antibody (TER-119) can be used to construct a model of immune thrombocytopenic purpura combined with CD41 mAb[1][2][3]
Medchemexpress LLC Anti-Mouse Ter-119 A 5mg | 5mg
Anti-Mouse Ter-119 Antibody (TER-119) is an anti-mouse Ter-119 IgG2b monoclonal antibody Anti-Mouse Ter-119 Antibody (TER-119) can increase platelet count Anti-Mouse Ter-119 Antibody (TER-119) can remove red blood cells and their precursor cells to isolate and enrich natural killer (NK) cells Anti-Mouse Ter-119 Antibody (TER-119) can be used for research on immune thrombocytopenia Anti-Mouse Ter-119 Antibody (TER-119) can be used to construct a model of immune thrombocytopenic purpura combined with CD41 mAb[1][2][3]
Medchemexpress LLC Anti-Mouse Ter-119 A 1mg | 1mg
Anti-Mouse Ter-119 Antibody (TER-119) is an anti-mouse Ter-119 IgG2b monoclonal antibody Anti-Mouse Ter-119 Antibody (TER-119) can increase platelet count Anti-Mouse Ter-119 Antibody (TER-119) can remove red blood cells and their precursor cells to isolate and enrich natural killer (NK) cells Anti-Mouse Ter-119 Antibody (TER-119) can be used for research on immune thrombocytopenia Anti-Mouse Ter-119 Antibody (TER-119) can be used to construct a model of immune thrombocytopenic purpura combined with CD41 mAb[1][2][3]
Medchemexpress LLC OP-1074 | 1443752-76-8 | 99.8% | 457.56 | 5 MG
OP-1074 is a pure anti-estrogen drug, functioning as a selective ER degrader (PA-SERD). It exhibits specific anti-estrogenic activity against ERα and ERβ.
- Inhibits 17β-estradiol (E2)-stimulated transcription with IC50 values of 1.6 nM for ERα and 3.2 nM for ERβ.
- Inhibits the proliferation of MCF-7 and CAMA-1 cells with IC50 values of 6.3 nM and 9.2 nM, respectively, after 24 hours.
- Destabilizes ERα protein expression in MCF-7 and CAMA-1 cells at 100 nM for 24 hours.
Medchemexpress LLC TAS-119 | 1453099-83-6 | 98.0% | 506.36 | 25 MG
TAS-119 is a potent, selective, and orally active Aurora A inhibitor. It exhibits an IC50 of 1.0 nM for Aurora A and 95 nM for Aurora B. This compound has demonstrated potent antitumor activities, enhancing the antiproliferative effect of Paclitaxel in various human cancer cell lines, including drug-resistant ones.
- Potent, selective, and orally active Aurora A inhibitor
- IC50 of 1.0 nM for Aurora A
- High selectivity over Aurora B (IC50 of 95 nM)
- Demonstrates potent antitumor activities
- Enhances antiproliferative effect of Paclitaxel
- Induces mitotic accumulation in tumor cells
- For research use only
Medchemexpress LLC Synstatin (92-119) | 1259384-47-8 | 99.4% | 3032.27 | 5 MG
Synstatin (92-119) is an inhibitor of αvβ3/αvβ5 integrins and IGF1R, exhibiting anti-angiogenic, anti-proliferative, antioxidant, and anti-tumor activities. It competitively blocks the capture of αvβ3/αvβ5 integrins and IGF1R by syndecan-1, disrupting the formation of the syndecan-1: integrin: IGF1R ternary complex. It also inhibits integrin activation, talin-mediated signaling, and VEGF-induced angiogenesis, making it suitable for cancer and hepatocellular carcinoma research.
- Directly inhibits assembly of Sdc1:αvβ3 integrin:IGF1R ternary complex
- Binds to αvβ3 integrin, αvβ5 integrin, and IGF1R on activated vascular endothelial cells
- Inhibits αvβ3-dependent adhesion and migration of tumor cells
- Inhibits VEGF- and αvβ3-dependent angiogenesis
- Reduces hepatocellular carcinoma progression in thioacetamide-induced rats
Medchemexpress LLC bFGF (119-126) | 152051-61-1 | 99.93% | 993.16 | 10 MG
bFGF (119-126) is a ligand of basic fibroblast growth factor (bFGF) that inhibits its interaction with fibroblast growth factor receptor 1 (FGFR1). This suppresses FGFR1 phosphorylation and downstream signaling, leading to cell apoptosis and inhibition of proliferation, migration, angiogenesis, and metastasis. It can enhance cellular uptake when conjugated with a carrier and has shown enhanced tumor inhibitory effects in combination with ultrasound and Doxorubicin, useful in various cancer research.
- Enhances cellular uptake via FGFR-mediated endocytosis when conjugated with a carrier
- Effective FGFR-targeted ligand
- Enhances tumor inhibitory effects when combined with ultrasound and Doxorubicin
- Applicable for research in lung, breast, glioblastoma, and ovarian cancers.