4-alkoxyphenols
Medchemexpress LLC 3-methoxyphenol | 150-19-6 | MFCD00002267 | 98.9% | 1mL
3-Methoxyphenol is a phenolic compound that is biologically toxic 3-Methoxyphenol is systemically absorbed disrupts the function of the liver kidneys central nervous system and redox processes and increases levels of Hb red blood cells and white blood cells in the body
Medchemexpress LLC 3-Methoxyphenol | 150-19-6 | MFCD00002267 | 25g
3-Methoxyphenol is a phenolic compound that is biologically toxic 3-Methoxyphenol is systemically absorbed disrupts the function of the liver kidneys central nervous system and redox processes and increases levels of Hb red blood cells and white blood cells in the body
Medchemexpress LLC 3-methoxyphenol | 150-19-6 | MFCD00002267 | 100g
3-Methoxyphenol is a phenolic compound that is biologically toxic 3-Methoxyphenol is systemically absorbed disrupts the function of the liver kidneys central nervous system and redox processes and increases levels of Hb red blood cells and white blood cells in the body
Medchemexpress LLC CHS-828 (GMX1778) | 200484-11-3 | 99.3% | 371.86 | 25 MG
CHS-828 (GMX1778) is a competitive inhibitor of nicotinamide phosphoribosyltransferase (NAMPT) with an IC50 of less than 25 nM. It decreases cellular NAD+ levels, exerting a cytotoxic and potent anticancer effect. The compound increases intracellular reactive oxygen species (ROS) in cancer cells by elevating superoxide levels without inducing ROS in normal cells. Its ROS-inducing effects can be modulated by nicotinic acid in a NAPRT1-dependent manner.
- Competitive inhibitor of NAMPT (IC50 < 25 nM).
- Decreases cellular NAD+ levels.
- Demonstrates potent anticancer activity.
- Increases intracellular ROS in cancer cells.
- Does not induce ROS in normal cells.
- ROS induction can be reduced by nicotinic acid.
Medchemexpress LLC PI-828 | 942289-87-4 | 99.62% | 322.36 | 100 MG
PI-828 is a dual inhibitor of PI3K and casein kinase 2 (CK2) with IC50s of 173 nM for p110α, 149 nM for CK2, and 1127 nM for CK2α2 in a lipid kinase assay. It is intended for research use only.
- Dual PI3K and casein kinase 2 (CK2) inhibitor.
- Exhibits cytotoxic effect on 4T1 breast cancer cells and 4306 ovarian cancer cells.
- Decreases caspase 3 activation at concentrations ranging from 0.78 to 3.12 μM; higher concentrations (6.25-12.5 μM) alone induce apoptosis.
Medchemexpress LLC CHS-828 (GMX1778) | 200484-11-3 | MFCD03700766 | 99.3% | 371.86 g/mol | C19H22ClN5O | 100 MG
CHS-828 (GMX1778) is a small-molecule competitive inhibitor of nicotinamide phosphoribosyltransferase (NAMPT) used for research and analytical applications. It lowers cellular NAD+ levels and shows cytotoxic activity in cancer cell models. Supplied as a high-purity analytical standard for laboratory use.
- Competitive inhibitor of nicotinamide phosphoribosyltransferase (NAMPT).
- Reduces cellular NAD+ levels leading to cytotoxic effects in cell models.
- High purity suitable for analytical and research applications.
- Provided as a solid analytical standard for easy handling and storage.
- Intended for research use only; not for human or clinical use.
Medchemexpress LLC PI-828 | 942289-87-4 | 99.6% | 322.36 | 25 MG
PI-828 is a dual inhibitor targeting both PI3K and casein kinase 2 (CK2). This compound demonstrates inhibitory activity against p110α, CK2, and CK2α2 in lipid kinase assays, making it suitable for various research applications.
- Dual inhibitor of PI3K and casein kinase 2 (CK2)
- IC50 of 173 nM for p110α
- IC50 of 149 nM for CK2
- IC50 of 1127 nM for CK2α2
- Shows cytotoxic effects on 4T1 breast and 4306 ovarian cancer cells
- Decreases caspase 3 activation and induces apoptosis in NCCIT cells
Medchemexpress LLC 3,4-Dimethoxyphenol | 2033-89-8 | 154.16 | 50 G
3,4-Dimethoxyphenol is a plant-derived phenylpropanoid compound that can be used as a whitening agent in cosmetics. It exhibits broad-spectrum antimicrobial activity, tyrosinase-inhibiting activity, and a potent antioxidant effect, isolated from bacterial fermentation broth. It can be used for the study of infection.
- Induces morphological damage in Xoo cells (62.5-125 μg/mL in vitro).
Apexbio Technology LLC 3-5-DIMETHOXYPHENOL-500MG
3 5-Dimethoxyphenol (CAS No 500-99-2) is a compound of interest in the biomedical research field originating from phenolic derivatives Its mechanism of action involves modulation of oxidative stress pathways where it acts as an antioxidant by neutralizing free radicals Researchers have observed its in vitro activity in the nanomolar to low micromolar range highlighting its potency in cellular assays Typical applications include investigations using cell models such as fibroblasts and hepatocytes as well as in animal studies to explore its potential therapeutic effects This compound is also utilized in drug screening to assess antioxidant properties Experimental concentrations typically depend on the specific research design ensuring targeted efficacy without toxicity
Apexbio Technology LLC 3-5-DIMETHOXYPHENOL-1G
3 5-Dimethoxyphenol (CAS No 500-99-2) is a compound of interest in the biomedical research field originating from phenolic derivatives Its mechanism of action involves modulation of oxidative stress pathways where it acts as an antioxidant by neutralizing free radicals Researchers have observed its in vitro activity in the nanomolar to low micromolar range highlighting its potency in cellular assays Typical applications include investigations using cell models such as fibroblasts and hepatocytes as well as in animal studies to explore its potential therapeutic effects This compound is also utilized in drug screening to assess antioxidant properties Experimental concentrations typically depend on the specific research design ensuring targeted efficacy without toxicity
Medchemexpress LLC 1,1,1,3,3,3-hexafluoropropan-2-yl 4-(3-phenoxybenzyl)piperazine-1-carboxylate | 1416133-89-5 | MFCD22987956 | 99.9% | 462.39 | C21H20F6N2O3 | 50MG
JW-642 is a research-grade, selective inhibitor of monoacylglycerol lipase (MAGL) used to probe endocannabinoid signaling and lipid metabolism. It provides low-nanomolar potency against MAGL across species while showing much weaker activity against fatty acid amide hydrolase, supporting its use as a selective pharmacological tool.
- Potent MAGL inhibition in human, mouse, and rat (IC50: 3.7 nM human; 7.6 nM mouse; 14 nM rat).
- Reduced activity versus FAAH (micromolar IC50s), indicating selectivity.
- High purity (99.9% by HPLC) for consistent experimental performance.
- Solid, stable material suitable for analytical and preparative applications.
- Recommended storage under nitrogen at 4°C; in solution store at -80°C for long-term stability.
- Suitable for biochemical, enzymatic, and cell-based assays.