Aminophenols
Medchemexpress LLC CC-115 hydrochloride | 1300118-55-1 | 98.01% | 372.81 | 1 ML
CC-115 hydrochloride is a potent, dual DNA-PK and mTOR kinase inhibitor. It targets both mTORC1 and mTORC2 signaling, making it a valuable tool for research applications. This compound has demonstrated significant inhibitory effects against PC-3 cell proliferation and exhibits good in vivo pharmacokinetic profiles, including high oral bioavailability in various animal models.
- Potent DNA-PK inhibitor (IC50 of 13 nM)
- Potent mTOR kinase inhibitor (IC50 of 21 nM)
- Blocks both mTORC1 and mTORC2 signaling
- Inhibits PC-3 cell proliferation with an IC50 of 138 nM
- Exhibits good in vivo pharmacokinetic profiles
- Demonstrates high oral bioavailability in mouse, rat, and dog
- Sustains inhibition through 24 hours
- Shows tumor volume reductions in vivo studies
Medchemexpress LLC ZLN024 hydrochloride | 1883548-91-1 | 98.5% | 361.69 | 100 MG
ZLN024 hydrochloride is an allosteric activator of AMPK. It directly activates recombinant AMPK α1β1γ1, AMPK α2β1γ1, AMPK α1β2γ1, and AMPK α2β2γ1 heterotrimers.
- Allosterically stimulates active AMPK heterotrimers and inactive α1 subunit truncations.
- AMPK activation requires pre-phosphorylation of Thr-172 and protects AMPK Thr-172 against dephosphorylation by PP2Cα.
- Activates AMPK in L6 myotubes, stimulating glucose uptake and fatty acid oxidation without increasing the ADP/ATP ratio.
- Increases the activity of α1β1γ1 by 1.5-fold (EC50 of 0.42 μM), α2β1γ1 by 1.7-fold (EC50 of 0.95 μM), α1β2γ1 by 1.7-fold (EC50 of 1.1 μM), and α2β2γ1 by 1.6-fold (EC50 of 0.13 μM).
- Improves glucose tolerance in C57BKS db/db mice after 4 weeks of treatment.
- Reduces fasting blood glucose by 15%, liver tissue weight, triacylglycerol, and total cholesterol content in mice.
eMolecules 125697-91-8 | Medchem Express | Lavendustin B | 5mg | 596608002 | HY-108935 | MFCD00133446 | 365.385 | C21H19NO5
Medchem Express | S-acetyl-PEG4-propargyl | 50mg | 752823151 | HY-141350 | 1422540-88-2 | MFCD29764347 | 290.370 | C13H22O5S
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Medchemexpress LLC YIL781 hydrochloride | 1640226-17-0 | 99.5% | 445.96 g/mol | C24H29ClFN3O2 | 5 MG
YIL781 hydrochloride is the hydrochloride salt of a potent, orally active ghrelin receptor (GHSR) antagonist used in preclinical research to study ghrelin signaling, metabolic regulation, and insulin secretion. The compound is provided with solubility guidance and storage recommendations for reliable use in experimental workflows.
- Potent ghrelin receptor (GHSR) antagonist suitable for pharmacological studies.
- Usable in vitro and in vivo applications.
- High purity (~99.5%) for reliable experimental results.
- Soluble in DMSO; formulation guidance provided for aqueous preparations.
- Stable when stored sealed at -20°C; solvent stability recommendations available.
- Available in small research pack sizes for early-stage studies.
Medchemexpress LLC CBB1007 hydrochloride | 2070014-96-7 | C27H39Cl5N8O4 | 50 MG
CBB1007 hydrochloride is a reversible and selective LSD1 inhibitor. It significantly blocks the demethylase activity of LSD1 on H3K4Me2 and H3K4Me, showing selectivity for LSD1 over LSD2 or JARID1A. This compound induces differentiation-related genes in pluripotent cells and is studied in non-pluripotent cancer research, targeting teratocarcinoma, embryonic carcinoma, and seminoma.
- Reversible and selective LSD1 inhibitor
- Blocks demethylase activity of LSD1 on H3K4Me2 and H3K4Me
- Induces differentiation-related genes in pluripotent cells
- Targeted in non-pluripotent cancer research
TARGETMOL CHEMICALS INC L-Azidohomoalanine hydrochlori
Also available in 5 mg, 10 mg, 25 mg, 50 mg, 200 mg and bulk. Please contact Fisher for quotes. L-Azidohomoalanine hydrochloride (H-L-Aha-OH hydrochloride) is an alkyl chain-based PROTAC linker. Purity 98.16%
Cayman Chemical Acetaminophen Inhibitors
An analgesic and antipyretic compound; an inhibitor of COX-2 that is selective over COX-1 (IC50s = 113.7 and 25.8 µM, respectively, in human blood ex vivo); induces ferroptotic cell death in primary mouse hepatocytes; has a metabolite that depletes glutathione reserves in the liver
![Medchemexpress LLC 4-pyridinecarboxylic acid, 2-[[[2-[[2-(dimethylamino)ethyl]...]]-, hydrochloride | 3026728-26-4 | 96.6% | 25 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000231786.png-250.jpg)
Medchemexpress LLC 4-pyridinecarboxylic acid, 2-[[[2-[[2-(dimethylamino)ethyl]...]]-, hydrochloride | 3026728-26-4 | 96.6% | 25 MG
KDM5-C49 hydrochloride is a potent, selective inhibitor of KDM5 histone demethylases used for biochemical and cellular research, including cancer studies. It is supplied as a high-purity solid-liquid mixture with defined storage recommendations to maintain stability.
- Potent KDM5 inhibitor with reported IC50s of 40 nM (KDM5A), 160 nM (KDM5B), and 100 nM (KDM5C).
- High purity suitable for research applications.
- Molecular weight approximately 344.84 g/mol.
- Physical form: solid-liquid mixture, colorless to light yellow.
- Recommended storage: 4°C sealed; stock solutions: -80°C (up to 6 months) or -20°C (up to 1 month).
- Available in small milligram pack sizes for laboratory use.
Medchemexpress LLC HY-100689 5mg Medchemexpress, Propyl pyrazole triol CAS:263717-53-9 Purity:>98%
Medchemexpress, HY-100689 5mg Propyl pyrazole triol CAS:263717-53-9 Propyl pyrazole triol (PPT) is an estrogen receptor alpha (ERα) agonist. The relative binding affinity of Propyl pyrazole triol for ERα (ERα: 49%) around 410 times higher compared with estrogen receptor beta (ERβ: 0.12%) [1] . Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC A-350619 hydrochloride | 1217201-17-6 | ≥99.0% | 425.41 g/mol | C21H25ClN2OS·HCl | 10 MG
A-350619 hydrochloride is a small-molecule soluble guanylate cyclase (sGC) activator used in preclinical research. It enhances cGMP production by activating basal sGC and synergizing with nitric oxide, producing vasodilatory effects such as cavernosum smooth muscle relaxation and increased blood flow in animal models. The material is supplied as a hydrochloride salt for improved solubility.
- High purity suitable for in vitro and in vivo studies.
- Soluble hydrochloride salt with good DMSO and aqueous solubility.
- Activates soluble guanylate cyclase and enhances NO-mediated signaling.
- Demonstrated vasodilatory and penile erection effects in rodent models.
- Store at 4°C to maintain stability.
eMolecules 1448584-12-0 | Medchem Express | S55746 | 5mg | 446260465 | HY-117288 | 710.831 | C43H42N4O6
Ambeed | (R)-2-(6-Methylpyridin-2-yl)-4-phenyl-45-dihydrooxazole | 100mg | 649269024 | A1476160 | 199277-73-1 | 238.290 | C15H14N2O
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Medchemexpress LLC MT-7716 hydrochloride | 1215859-93-0 | 99.1% | 477.0 | C27H29ClN4O2 | 1 ML
MT-7716 hydrochloride is the hydrochloride salt of a selective non-peptide nociceptin (NOP) receptor agonist used for preclinical pharmacology research. It is supplied at high purity and is offered both as a ready-to-use DMSO solution and as solid quantities for formulation and biological testing. The compound is commonly used in studies of alcohol dependence, withdrawal, and relapse mechanisms.
Medchemexpress LLC CGP71683 hydrochloride | 192322-50-2 | MFCD07783999 | 99.4% | 512.07 g/mol | C26H30ClN5O2S | 50 MG
CGP71683 hydrochloride is a selective, non-peptide neuropeptide Y (NPY) Y5 receptor antagonist used for in vitro pharmacology and receptor signaling studies. The compound is supplied as a white solid and as a 10 mM solution in DMSO and is reported with high purity for research applications.
- Selective NPY Y5 receptor antagonist with low nanomolar affinity.
- Reported high purity suitable for research use.
- Available as a solid and as a 10 mM solution in DMSO for assay convenience.
- Molecular weight 512.07 g/mol aiding stoichiometric calculations.
- CAS registry number 192322-50-2 for unambiguous identification.
- Intended for biochemical and pharmacological studies in vitro.