Aminophenols
Medchemexpress LLC Sotalol (hydrochloride) | 959-24-0 | 99.9% | 1 ML
Sotalol hydrochloride is an orally active, non-selective β-adrenergic receptor blocker and a potent antiarrhythmic agent. It is used for the research of pediatric arrhythmias. Sotalol hydrochloride blocks β-receptors and potassium KCNH2 channels, and acts as an Antiepileptic Agent.
- Orally active
- Non-selective β-adrenergic receptor blocker
- Potent antiarrhythmic agent
- Blocks β-receptors
- Blocks potassium KCNH2 channels
- Acts as an antiepileptic agent
- Used for pediatric arrhythmias research
Medchemexpress LLC Benzenepropanol | 122-97-4 | 99.8% | 136.19 | 1000 G
Benzenepropanol is a biochemical reagent that can be used as a biological material or organic compound for life science related research. It is for research use only and not sold to patients.
- It has a liquid appearance.
- Its color ranges from colorless to light yellow.
- Pure form can be stored at -20°C for 3 years, or 4°C for 2 years.
- It is soluble in DMSO at 100 mg/mL.
- Various in vivo dissolution protocols are available.
Medchemexpress LLC UNC9994 hydrochloride | 2108826-33-9 | 99.5% | 457.84 | 100 MG
UNC9994 hydrochloride is a functionally selective, β-arrestin-biased dopamine D2 receptor (D2R) agonist that selectively activates β-arrestin recruitment and signaling. It shows a binding affinity with a Ki of 79 nM for D2R. UNC9994 hydrochloride is also an antagonist of Gi-regulated cAMP production and a partial agonist for D2R/β-arrestin-2 interactions. It demonstrates antipsychotic-like activity. It is for research use only.
- Functions as a β-arrestin-biased dopamine D2 receptor agonist.
- Selectively activates β-arrestin recruitment and signaling.
- Exhibits a binding affinity (Ki) of 79 nM for D2R.
- Acts as an antagonist of Gi-regulated cAMP production.
- Serves as a partial agonist for D2R/β-arrestin-2 interactions.
- Demonstrates antipsychotic-like activity.
eMolecules Key Organics/BIONET Medetomidine Hydrochloride 10mg 564356419 AS-2748 99 000 86347-15-1 236 740 C13H17ClN2
Key Organics/BIONET Medetomidine Hydrochloride 10mg 564356419 AS-2748 99 000 86347-15-1 236 740 C13H17ClN2
eMolecules 3-METHYL-5-NITROPHENOL | 127818-58-0 | MFCD09038591 | 1g
WuXi ChemSupply | 3-METHYL-5-NITROPHENOL | 1g | 599166725 | LN00335137 | 95.000 | 127818-58-0 | MFCD09038591 | 153.137 | C7H7NO3
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Medchemexpress LLC Abaucin hydrochloride | 1173022-16-6 | >98% | 426.86 | 1 ML
Abaucin hydrochloride is a potent CCR2 antagonist (IC50: 360 nM) with no effect on CCR1, primarily used in neurological disease and endocrinology research. It targets human α1a, α1d receptors, and rat brain cortex 5HT1a receptor, and suppresses wild type and D284N mutant MCP-1 receptor activity. In vivo studies show it decreases pain thresholds in rats with bone cancer pain.
- Potent CCR2 antagonist (IC50: 360 nM), no effect on CCR1
- Inhibits α1a, α1d, and 5HT1a receptors
- Suppresses wild type and D284N mutant MCP-1 receptor
- Reduces extracellular matrix protein expression
- Blocks fibronectin and type IV collagen expression in high glucose-stimulated mesangial cells
- Abrogates increased TGF-1 levels in mesangial cells
- Decreases pain threshold in rats with bone cancer pain
- Reverses NR2B, nNOS, and SIGIRR expression in spinal cord
- Used in neurological disease and endocrinology research
Medchemexpress LLC Chromotropic acid disodium dihydrate | 5808-22-0 | MFCD00150612 | 400.29 g/mol | C10H10Na2O10S2 | 25G
Chromotropic acid disodium dihydrate is the disodium salt dihydrate of chromotropic acid used as an analytical reagent for colorimetric detection of formaldehyde and as a staining/dyeing reagent. It is supplied in multiple pack sizes, including a 25 g unit, and is characterized by the molecular formula C10H10Na2O10S2 and a molecular weight of 400.29 g/mol.
- Reagent for colorimetric detection of formaldehyde.
- Available in multiple pack sizes, including 25 g.
- Provided as the disodium salt dihydrate form.
- Molecular formula C10H10Na2O10S2; molecular weight 400.29 g/mol.
- Suitable for analytical and staining applications.
Medchemexpress LLC CX-6258 hydrochloride | 1353859-00-3 | 99.0% | 498.40 | 50 MG
CX-6258 hydrochloride is a potent and kinase-selective pan-Pim kinases inhibitor, demonstrating IC50s of 5 nM for Pim-1, 25 nM for Pim-2, and 16 nM for Pim-3.
- Causes dose-dependent inhibition of the phosphorylation of pro-survival proteins, bad and 4e-bp1, at specific pim kinase sites.
- Treatment diminishes steady-state levels of ectopic nkx3.1 in pc3 cells.
- Treatment results in a significant reduction in nkx3.1 half-life.
- Exhibits robust in vivo efficacy in two pim kinase-driven tumor models.
- Demonstrates dose-dependent efficacy, producing 45% tumor growth inhibition at 50 mg/kg and 75% tumor growth inhibition at 100 mg/kg.
Medchemexpress LLC Cyclohexanecarboxylic acid, 1-phenyl-, 2-(4-morpholinyl)ethyl ester, hydrochloride (1:1) | 75136-54-8 | 99.79% | 353.88 | 5 MG
PRE-084 hydrochloride is a highly selective σ1 receptor (S1R) agonist with an IC50 of 44 nM.
- Exhibits good neuroprotective effects.
- Can improve motor function and motor neuron survival in mice.
- Can ameliorate myocardial ischemia-reperfusion injury in rats by activating the Akt-eNOS pathway.
Medchemexpress LLC 9-Hexadecenoic acid, 1,1'-[(9,10-dihydro-5,8-dihydroxy-9,10-dioxo-1,4-anthracenediyl)bis(imino-2,1-ethanediy... | 1349197-90-5 | 98.37% | 917.27 | 25 MG
di-Pal-MTO is a palm oil-based lipid created by combining the anticancer agent mitoxantrone (MTO) with palmitoleic acid. When nanoparticles of mono-Pal-MTO and di-Pal-MTO are combined in a molar ratio of 1:1, they effectively deliver siRNA to cells and enhance anticancer activity.
- Effective siRNA cell delivery
- Enhances anticancer activity
- Reduces tumor cell viability by 81% in vitro
- Reduces tumor size by 83% in vitro
Medchemexpress LLC HAIYPRH hydrochloride | 100.0% | 929.46 | 5 MG
HAIYPRH hydrochloride is a targeting ligand that specifically binds to the transferrin receptor (TfR). It can mediate the transport of nanocarriers across the blood-brain barrier.
- Can be conjugated to liposomes for ischemic stroke targeting treatment.
- Heptapeptide that can be used to target gliomas.
- Used as a ligand to target co-delivery systems to tumor cells expressing transferrin receptors.
- Modified co-delivery systems show higher efficiency in cellular uptake and gene expression in U87 MG cells.
- Modified co-delivery systems accumulate in tumors more efficiently in vivo.