Aminophenols
Medchemexpress LLC AZD9056 hydrochloride | 345303-91-5 | 98.2% | 455.46 | 50 MG
AZD9056 hydrochloride is a selective orally active inhibitor of P2X7, which plays a significant role in inflammation and pain-causing diseases. It is for research use only and not sold to patients.
- Selective orally active inhibitor of P2X7.
- Blocks P2X7 receptors with an IC50 of 11.2 nM in HEK-hP2X7 cell line.
- Exhibits high selectivity for the P2X7 receptor.
- Has an inhibitory effect (IC50=1-3 μM) in mouse microglia BV2 cells.
- Weakly inhibits BCRP-mediated transport of methotrexate (IC50=92 μM).
- Exerts pain-relieving and anti-inflammatory effects in vivo.
- Reverses upregulated expression of IL-1β, IL-6, TNF-α, MMP-13, SP, and PGE2 induced by MIA in cartilage tissues.
Medchemexpress LLC Oxprenolol-d7 hydrochloride | 1189649-47-5 | 98.3% | 308.85 | C15H17D7ClNO3 | 10 MG
Oxprenolol-d7 hydrochloride is a deuterium-labeled hydrochloride salt of oxprenolol used as an analytical standard and internal standard for LC-MS and other quantitative assays. Supplied at high purity in mg-scale packages, follow recommended cold storage to preserve stability.
- Deuterium-labeled hydrochloride salt for use as an analytical/internal standard.
- High purity (98.25%) for accurate quantitation.
- Available in mg-scale packages to support method development.
- Recommended storage: powder -20°C (3 years) or 4°C (2 years).
- Molecular formula C15H17D7ClNO3 and molecular weight 308.85 for identification.
Medchemexpress LLC AM-92016 hydrochloride | 133229-11-5 | 99.3% | 483.84 g/mol | C19H25Cl3N2O4S | 10 MG
AM-92016 hydrochloride is a research-grade small molecule that selectively blocks the rectifier potassium current (IK), delaying IK-mediated repolarization and restricting action potential duration. It is supplied as a high-purity solid intended for use in electrophysiology and ion-channel research.
- Specific blocker of rectifier potassium current (IK).
- Suitable for electrophysiology and ion-channel research.
- High purity (99.3%) for reliable experimental results.
- Solid, light yellow to yellow appearance.
- Storage: sealed at 4°C; in solvent -80°C (6 months) or -20°C (1 month).
- Pack size 10 mg for small-scale studies.
Medchemexpress LLC PD153035 hydrochloride | 183322-45-4 | 99.5% | 50 MG
PD153035 hydrochloride is the hydrochloride salt of a potent epidermal growth factor receptor (EGFR) inhibitor used in biochemical and cellular research. It is supplied as a high-purity, well-characterized small-molecule reagent with defined solubility and storage recommendations.
- Potent EGFR inhibitor with reported Ki = 6 pM and IC50 = 25 pM.
- High purity: 99.48%.
- Molecular formula C16H15BrClN3O2; molecular weight 396.67 g/mol.
- Soluble in DMSO (4 mg/mL); insoluble in water (< 0.1 mg/mL).
- Recommended storage: solid at 4°C; in solution -80°C (6 months) or -20°C (1 month).
- Supplied as a 50 mg package for research use.
Medchemexpress LLC BN82002 hydrochloride | 1049740-43-3 | 99.4% | 395.88 | 1 ML
BN82002 hydrochloride | 1049740-43-3 | 99.4% | 395.88 | 1 ML
Medchemexpress LLC ZK824859 hydrochlori 50mg | 2436760-76-6 | 50 MG
ZK824859 hydrochloride is a research-stage small-molecule hydrochloride salt that functions as an orally available, selective inhibitor of urokinase plasminogen activator (uPA). Reported potency includes IC50 values of 79 nM for human uPA, 1,580 nM for tPA, and 1,330 nM for plasmin. The compound is supplied as a solid powder for in vitro and in vivo research use.
- Orally available uPA inhibitor.
- Selective activity: human uPA IC50 = 79 nM; tPA = 1,580 nM; plasmin = 1,330 nM.
- Hydrochloride salt form for improved solubility.
- CAS 2436760-76-6; molecular formula C23H23ClF2N2O4; molecular weight 464.89 g·mol-1.
- Common research package sizes include 25 mg and 50 mg.
Medchemexpress LLC Metixene hydrochloride hydrate | 7081-40-5 | 99.9% | 50 MG
Metixene hydrochloride hydrate is an anticholinergic and antiparkinsonian research chemical supplied as a white to off-white solid for laboratory research. It is offered in multiple lab-scale pack sizes and in ready-to-use DMSO solution formats.
- White to off-white solid appearance.
- High reported purity of 99.9%.
- Available in multiple pack sizes including 50 MG.
- Chemical formula C20H26ClNOS; molecular weight 363.94.
- Offered in DMSO solution formats for ready use.
![Medchemexpress LLC Urea, N-[4-[4-(4-morpholinyl)-6-(3-oxa-8-azabicyclo[3.2.1]oct-8-yl)-1,3,5-triazin-2-yl]phenyl]-N'-4-pyridinyl-, hydrochloride (1:1) | 1463510-35-1 | 99.7% | 525.00 | 25 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/default.jpg-250.jpg)
Medchemexpress LLC Urea, N-[4-[4-(4-morpholinyl)-6-(3-oxa-8-azabicyclo[3.2.1]oct-8-yl)-1,3,5-triazin-2-yl]phenyl]-N'-4-pyridinyl-, hydrochloride (1:1) | 1463510-35-1 | 99.7% | 525.00 | 25 MG
PKI-179 hydrochloride is a potent and orally active dual PI3K/mTOR inhibitor. It shows anti-tumor activity in vivo, inhibiting tumor growth and PI3K signaling without significant weight loss in animal models. The product is suitable for laboratory research applications.
- Potent and orally active dual PI3K/mTOR inhibitor
- Anti-tumor activity in vivo
- Inhibits cell proliferation
- Available as a white to off-white solid
- Tested and complies with specifications
Medchemexpress LLC AT7519 Hydrochloride | 902135-91-5 | 98.6% | C16H18Cl3N5O2 | 25 MG
AT7519 Hydrochloride is a potent inhibitor of CDKs, with IC50s of 210, 47, 100, 13, 170, and <10 nM for CDK1, CDK2, CDK4 to CDK6, and CDK9, respectively. It is for research use only.
- Potent inhibitor of CDKs.
- Induces dose-dependent cytotoxicity and apoptosis in multiple myeloma cells.
- Inhibits cell cycle progression and induces apoptosis in human tumor cell lines.
- Inhibits transcription and RNA polymerase II in leukemia cell lines.
- Inhibits tumor growth in human xenograft mouse models.
- Investigated in clinical trials for various cancers.
Medchemexpress LLC CX-6258 hydrochloride hydrate | 1353858-99-7 | 99.2% | 516.42 | 1 ML
CX-6258 hydrochloride hydrate is a potent and kinase selective pan-Pim kinases inhibitor, with IC50s of 5 nM, 25 nM and 16 nM for Pim-1, Pim-2 and Pim-3, respectively.
- Potent and kinase selective pan-Pim kinases inhibitor
- IC50s of 5 nM (Pim-1), 25 nM (Pim-2), 16 nM (Pim-3)
- Causes dose-dependent inhibition of the phosphorylation of pro-survival proteins Bad and 4E-BP1 at specific Pim kinase sites (S112, S65, T37/46)
- Diminishes steady-state levels and reduces half-life of ectopic NKX3.1 in PC3 cells
- Exhibits robust in vivo efficacy in two Pim kinases driven tumor models (e.g., MV-4-11 xenograft models in nude mice)
![Medchemexpress LLC 4-pyridinecarboxylic acid, 2-[[[2-[[2-(dimethylamino)ethyl]...]]-, hydrochloride | 3026728-26-4 | 96.6% | 25 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000231786.png-250.jpg)
Medchemexpress LLC 4-pyridinecarboxylic acid, 2-[[[2-[[2-(dimethylamino)ethyl]...]]-, hydrochloride | 3026728-26-4 | 96.6% | 25 MG
KDM5-C49 hydrochloride is a potent, selective inhibitor of KDM5 histone demethylases used for biochemical and cellular research, including cancer studies. It is supplied as a high-purity solid-liquid mixture with defined storage recommendations to maintain stability.
- Potent KDM5 inhibitor with reported IC50s of 40 nM (KDM5A), 160 nM (KDM5B), and 100 nM (KDM5C).
- High purity suitable for research applications.
- Molecular weight approximately 344.84 g/mol.
- Physical form: solid-liquid mixture, colorless to light yellow.
- Recommended storage: 4°C sealed; stock solutions: -80°C (up to 6 months) or -20°C (up to 1 month).
- Available in small milligram pack sizes for laboratory use.
Medchemexpress LLC RS 67333 (hydrochloride) | 168986-60-5 | MFCD00938576 | 99.7% | 389.36 | C19H30Cl2N2O2 | 25 MG
RS 67333 hydrochloride is a research-grade, selective 5-HT4 receptor partial agonist used in preclinical and in vitro neuroscience studies to investigate serotonergic signaling and neuroprotective mechanisms.
- Potent, selective 5-HT4 receptor partial agonist for neuroscience research.
- High purity, 99.7% (as listed by manufacturer).
- Molecular weight 389.36 g/mol; formula C19H30Cl2N2O2.
- Solid, light yellow to yellow appearance supplied as a dry powder.
- Storage: 4°C, sealed and away from moisture; in solvent store at -80°C for long-term.
- Available as a 25 MG vial for laboratory use.
- CAS number 168986-60-5.
