Aminophenols
Medchemexpress LLC L-NAME hydrochloride (NG-Nitroarginine methyl ester hydrochloride) | 51298-62-5 | 99.9% | 269.69 | 500 MG
L-NAME hydrochloride is a nitric oxide synthase (NOS) inhibitor with an IC50 of 70 μM. It acts as a precursor to the more potent NOS inhibitor L-NOARG (IC50 of 1.4 μM), making it valuable in studies of L-arginine analogues that inhibit NOS activity. Its efficacy can increase with prolonged incubation at neutral or alkaline pH, correlating with its hydrolysis to L-NOARG. This compound is also used to induce hypertension and preeclampsia models in animal studies.
- Inhibits NOS with an IC50 of 70 μM.
- Precursor to NOS inhibitor L-NOARG.
- Used to induce hypertension and preeclampsia models in animal studies.
- Appearance: solid, white to off-white.
- Storage: -20°C, sealed, away from moisture.
- In solvent: -80°C for 6 months; -20°C for 1 month.
Medchemexpress LLC R 59-022 (hydrochloride) | 93076-98-3 | MFCD34676749 | 98.9% | 496.04 | C27H27ClFN3OS | 5 MG
R 59-022 (hydrochloride) is a research-grade small-molecule inhibitor used to probe diacylglycerol kinase (DGK) activity and downstream lipid signaling pathways in biochemical and cellular studies. The compound is supplied as a hydrochloride salt with reported molecular weight 496.04 and high analytical purity appropriate for laboratory research applications.
- Selective diacylglycerol kinase inhibitor activity.
- Potentiates protein kinase C activation in cellular assays.
- High purity suitable for biochemical and cell-based studies.
- Supplied as a hydrochloride salt to aid solubility in polar solvents.
- Provided in small research pack sizes for laboratory use.
Medchemexpress LLC ZZW-115 hydrochloride | 10122-45-9 | 98.09% | 573.97 | 25 MG
ZZW-115 hydrochloride is a potent NUPR1 inhibitor with a Kd of 2.1 μM. It induces tumor cell death through necroptosis and apoptosis, demonstrating anticancer activity.
- Effective in killing cancer cells with IC50 values ranging from 0.84 μM to 4.93 μM in various cell lines in vitro.
- Induces pancreatic cell death by necrosis and apoptosis, leading to decreased ATP production and increased ROS overproduction.
- Causes higher LDH release and greater caspase 3/7 activity in a concentration-dependent manner.
- Inhibits the growth of pancreatic xenografted tumors in mice when administered at 0.5-5 mg/kg daily for 30 days via injection.
- Dosage of 5 mg/kg for 30 days resulted in almost unmeasurable tumor sizes in some cases of C57BL/6 mice.
- Caused tumors to progressively decrease and almost disappear by the end of treatment in nude mice xenografted with MiaPaCa-2 cells at a 5 mg/kg dose.
Medchemexpress LLC NS8593 hydrochloride | 875755-24-1 | 99.76% | 299.80 | 1 MG
NS8593 hydrochloride is a potent and selective inhibitor of small conductance Ca2+-activated K+ channels (SK channels). It reversibly inhibits SK3-mediated currents with a Kd value of 77 nM. NS8593 hydrochloride inhibits all SK1-3 subtypes in a Ca2+-dependent manner (Kds of 0.42, 0.60, and 0.73 μM, respectively, at 0.5 μM Ca2+), but does not affect intermediate and large conductance Ca2+-activated K+ channels (hIK and hBK channels, respectively). It is for research use only and not sold to patients.
- Potent and selective small conductance Ca2+-activated K+ channels inhibitor
- Reversibly inhibits SK3-mediated currents with a Kd value of 77 nM
- Inhibits SK1-3 subtypes Ca2+-dependently
- Does not affect intermediate and large conductance Ca2+-activated K+ channels
- Affects firing rate and firing pattern of dopaminergic neurons in vivo in C57Bl/6 mice at doses of 3 and 10 mg/kg intravenously
Medchemexpress LLC Guvacine hydrochloride | 6027-91-4 | MFCD00055191 | 99.9% | 163.60 g/mol | C6H10ClNO2 | 25 MG
Guvacine hydrochloride is the hydrochloride salt of guvacine, a pyridine alkaloid that acts as a GABA uptake inhibitor. Supplied as a high-purity research reagent, it is used in biochemical and neuropharmacological studies to probe GABA transporter activity. The substance is intended for laboratory research use only and is not for human or veterinary use.
- High purity (99.93%) for reliable experimental results.
- Molecular weight 163.60 g/mol.
- Molecular formula C6H10ClNO2.
- CAS number 6027-91-4 for unambiguous identification.
- Available in multiple pack sizes and solution formats for flexible use.
- Suitable for in vitro biochemical and pharmacology research.
Medchemexpress LLC Mepazine hydrochloride | 2975-36-2 | 99.3% | 10 MG
Mepazine hydrochloride is a small-molecule MALT1 protease inhibitor used in cellular and biochemical research to study apoptosis and signaling pathways.
- High listed purity (99.25%).
- Molecular weight 346.92 g/mol and formula C19H23ClN2S.
- Available in small research pack sizes including 10 MG.
- Suitable for cellular assays probing MALT1 activity and apoptosis.
- Storage: solid at 4°C; solutions at -80°C for long-term, sealed and protected from moisture.
Medchemexpress LLC ZLN024 hydrochloride | 1883548-91-1 | 98.5% | 361.69 | 1 ML
ZLN024 hydrochloride is an allosteric activator of AMPK, directly stimulating active AMPK heterotrimers as well as inactive α1 subunit truncations. This activation requires pre-phosphorylation of Thr-172 by upstream kinases and protects AMPK Thr-172 from dephosphorylation. It activates AMPK in L6 myotubes, promoting glucose uptake and fatty acid oxidation without altering the ADP/ATP ratio. In vivo studies showed improved glucose tolerance and reduced fasting blood glucose in C57BKS db/db mice.
- Allosterically stimulates active AMPK heterotrimers.
- Activates AMPK in L6 myotubes.
- Stimulates glucose uptake and fatty acid oxidation.
- Improves glucose tolerance.
- Reduces fasting blood glucose.
Medchemexpress LLC LCKLSL hydrochloride | 98.1% | 712.34 | 1 MG
LCKLSL hydrochloride is an N-terminal hexapeptide and a competitive annexin A2 (AnxA2) inhibitor. It potently inhibits the binding of tissue plasminogen activator (tPA) to AnxA2, inhibits the generation of plasmin, and has anti-angiogenic roles. In human retinal microvascular endothelial cells (RMVECs), LCKLSL inhibits plasmin generation and suppresses VEGF-induced tPA activity under hypoxic conditions. Application in in vivo models of angiogenesis demonstrates suppression of angiogenic responses.
- Competitive annexin A2 (AnxA2) inhibitor
- Inhibits binding of tissue plasminogen activator (tPA) to AnxA2
- Inhibits generation of plasmin
- Anti-angiogenic roles
- Decreases vascular length in vivo
Cayman Chemical NGaminoLArginine hydrochlori
Inhibits nNOS, iNOS, and eNOS (Ki = 0.3, 3, and 2.5 μM, respectively); can be used both in cell culture and in vivo
Medchemexpress LLC Cyclohexanecarboxylic acid, 1-phenyl-, 2-(4-morpholinyl)ethyl ester, hydrochloride (1:1) | 75136-54-8 | 99.8% | 353.88 | 10 MG
PRE-084 hydrochloride is a highly selective σ1 receptor (S1R) agonist, with an IC50 of 44 nM. This product is intended for research and analytical applications.
- Highly selective σ1 receptor (S1R) agonist with an IC50 of 44 nM.
- Exhibits good neuroprotective effects.
- Can improve motor function and motor neuron survival in mice.
- Can ameliorate myocardial ischemia-reperfusion injury in rats by activating the Akt-eNOS pathway.
Medchemexpress LLC G-5555 hydrochloride | 2319590-15-1 | 98.3% | 529.42 | 1 ML
G-5555 hydrochloride is a potent and selective p21-activated kinase 1 (PAK1) inhibitor with a Ki of 3.7 nM.
- Excellent kinase selectivity, inhibiting only eight out of 235 kinases tested (>70% inhibition).
- High selectivity for group I PAKs.
- Negligible activity against the hERG channel (IC50 > 10 μM).
- Exhibits significantly greater growth inhibitory activity in PAK-amplified breast cancer cell lines.
- Low blood clearance and acceptable half-life in vivo.
- Good oral exposure (AUC=30 μM•h) and high oral bioavailability (F=80%) in vivo.
- Inhibits phosphorylation of MEK1 S298 and shows 60% tumor growth inhibition in xenograft models.
Cambridge Isotope Laboratories 4-AMINOPHENOL (D7, 98%), 1 G, 285132-88-9
4-AMINOPHENOL (D7, 98%), 1 G, 285132-88-9
eMolecules 3,4-Diaminophenol | 615-72-5 | MFCD06799539 | 1g
Combi-Blocks | 3,4-Diaminophenol | 1g | 205381631 | AN-3892 | 96.000 | 615-72-5 | MFCD06799539 | 124.143 | C6H8N2O
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