Aminophenols
Medchemexpress LLC Tas4464 (hydrochloride) | 1848959-11-4 | 98.9% | 25 MG
TAS4464 hydrochloride is a long-acting, highly selective covalent inhibitor targeting NEDD8-activating enzyme (NAE) with an IC50 of 0.955 nM. It exhibits antiproliferative and cytotoxic effects with broad-spectrum antitumor activity against various hematologic and solid tumor cell lines and patient-derived tumor cells. This compound has a wide therapeutic window without obvious toxicity and is suitable for research in hematologic malignancies and solid tumors.
- Highly potent and selective NAE inhibitor
- Demonstrates broad-spectrum antitumor activity against various cancer models
- Induces tumor cell apoptosis
- Increases protein expression levels of CRL ubiquitin ligase substrates
- Inhibits migratory capacity of solid tumor cell lines
- Achieves complete tumor regression in various animal models
- Prolongs survival and reduces tumor burden in lymphoma models
- Possesses a wide therapeutic window without obvious toxicity
Accela Chembio Inc 3-amino-5-hydroxybenzoic Acid Hydrochloride | 5g | 14206-69-0 | MFCD00043420 | 97+% | Shelf Life: 1620 Days | Light Sensitive/moisture Sensitive
3-amino-5-hydroxybenzoic Acid Hydrochloride | 5g | 14206-69-0 | MFCD00043420 | 97+% | Shelf Life: 1620 Days | Light Sensitive/moisture Sensitive
Medchemexpress LLC Axc-715 hydrochloride | 2490497-93-1 | 99.5% | C18H26ClN5 | 10MG
AXC-715 hydrochloride is the hydrochloride salt of a small-molecule TLR7/TLR8 dual agonist used for preclinical immunology and oncology research. Supplied for research use only, it is described as an immune adjuvant and has been used in synthesis of antibody-adjuvant conjugates and in vivo antitumor models.
- Dual TLR7/TLR8 agonist activity for immune-modulating studies
- High purity (99.5%) for reproducible experimental results
- Hydrochloride salt form improves aqueous solubility relative to the free base
- Suitable for conjugation and formulation in antibody-adjuvant constructs
- Available in small-scale research quantities for preclinical work
- Storage recommendations provided for solid and solution forms to maintain stability
Medchemexpress LLC AFM32a hydrochloride | 2988594-85-8 | 99.4% | 517.00 | 1 ML
AFM32a hydrochloride, also known as PAD2-IN-1 hydrochloride, is a potent and selective benzimidazole-based derivative that inhibits protein arginine deiminase 2 (PAD2). It demonstrates high selectivity, being 95-fold more selective for PAD2 over PAD4 and 79-fold more selective over PAD3.
- Potent and selective PAD2 inhibitor.
- Exhibits superior selectivity over PAD4 and PAD3.
- Effective in inhibiting histone H3 citrullination in HEK293T/PAD2 cells.
Chemscene ChemScene | 2,3-Diaminophenol | 10G | CS-W005863 | 0.97 | 59649-56-8| MFCD00075199 | 124.14
ChemScene | 2,3-Diaminophenol | 10G | CS-W005863 | 0.97 | 59649-56-8| MFCD00075199 | 124.14
Matrix Scientific 2,4-DICHLORO-6-AMINOPHENOL2-10
2,4-dichloro-6-aminophenol Mf C6h5cl2no Mw 178.02 Cas 527-62-8 Mdl MFCD00035766
Medchemexpress LLC Ethylenediaminetetraacetic acid sodium hydrate | 85715-60-2 | MFCD00013305 | 97.0% | 376.20 g/mol | C10H13N2Na3O8 · xH2O | 50 G
EDTA hydrate sodium is the trisodium salt hydrate form of ethylenediaminetetraacetic acid used as a chelating agent and biochemical reagent in life-science research. Supplied as a white to off-white solid with ~97.0% purity and a molecular weight of 376.20 g/mol, it is commonly used to sequester metal ions, stabilize formulations, and buffer solutions in laboratory applications.
- Chelates divalent and trivalent metal ions to prevent metal-catalyzed reactions.
- Stabilizes enzyme preparations and biochemical assays by binding trace metals.
- Acts as a buffer component in solution preparation and pH control.
- High-purity solid, easy to weigh and dissolve for reproducible results.
- Available in common laboratory pack sizes for convenient use.
Medchemexpress LLC MK-8033 hydrochloride | 1283000-43-0 | MFCD18633221 | ≥98.0% | C24H22Cl2N6O | 10MG
MK-8033 hydrochloride is a small-molecule, ATP-competitive dual inhibitor of c-Met and Ron kinases supplied as the hydrochloride salt for research use. It has been used in oncology research and was evaluated in early clinical trials; supplier listings report high purity and analytical characterization for laboratory applications.
- Potent dual c-Met and Ron kinase inhibitor
- Hydrochloride salt form
- Purity ≥98.0%
- Characterized by molecular formula and molecular weight
- Intended for research use in oncology studies
- Documented in early-phase clinical investigations
Medchemexpress LLC Iccb-19 hydrochloride | 1803605-68-6 | 99.3% | 291.84 | 1 ML
ICCB-19 hydrochloride is an inhibitor of TRADD (TNFRSF1A associated via death domain). It binds to the N-terminal domain of TRADD (TRADD-N), which prevents TRADD-N from binding to both TRADD-C and TRAF2. ICCB-19 hydrochloride also acts as an indirect inhibitor of RIPK1 kinase activity and effectively induces autophagy and the degradation of long-lived proteins.
- TRADD (TNFRSF1A associated via death domain) inhibitor.
- Binds with N-terminal domain of TRADD (TRADD-N), disrupting its binding to both TRADD-C and TRAF2.
- Indirect inhibitor of RIPK1 kinase activity.
- Induces autophagy and degradation of long-lived proteins.
- Inhibits Bortezomib-induced apoptosis and RIPK1-dependent apoptosis (RDA) with an IC50 of about 1 μM (In Vitro).
- Reduces inflammatory responses in Tradd-/- mice (In Vivo).
Medchemexpress LLC SKI-178 | 1259484-97-3 | 99.29% | 100 MG
SKI-178 is a potent inhibitor of sphingosine kinase-1 (SphK1) and SphK2. It exhibits cytotoxicity at IC50 concentrations ranging from 0.1 to 1.8 μM in various cancer cell lines, including MTR3, NCI-ADR, and HL60/VCR cells. SKI-178 induces apoptosis in human acute myeloid leukemia cell lines in a CDK1-dependent manner and has been shown to inhibit leukemic progression in an MLL-AF9 mouse model.
- Potent inhibitor of sphingosine kinase-1 (SphK1) and SphK2
- Exhibits cytotoxicity in multiple cancer cell lines
- Induces apoptosis in human acute myeloid leukemia cell lines
- Inhibits leukemic progression in MLL-AF9 mouse model
- Purity of 99.29%
- Soluble in DMSO for in vitro experiments
- Formulations suitable for oral and intraperitoneal injection for in vivo studies
Medchemexpress LLC 4-fluorobenzaldehyde | 459-57-4 | MFCD00003378 | 97.3% | 124.11 | C7H5FO | 1000g
4-Fluorobenzaldehyde is a biochemical reagent that can be used as a biological material or organic compound for life science related research
Medchemexpress LLC Ethylenediaminetetraacetic acid hydrate sodium | 85715-60-2 | MFCD00149675 | 97.0% | 376.20 g/mol | C10H13N2Na3O8 · xH2O | 100 G
Ethylenediaminetetraacetic acid sodium hydrate is a research-grade chelating agent and buffer component used to bind metal ions, stabilize solutions, and support a variety of laboratory protocols. It is supplied as a solid suitable for analytical and preparative applications.
- High purity (97.0%).
- Molecular weight: 376.20 g/mol.
- Chemical formula: C10H13N2Na3O8 · xH2O.
- Appearance: white to off-white solid.
- Function: chelating agent for metal ions and buffer formulations.
- Available in 100 G packaging for laboratory use.
Sigma Aldrich Fine Chemicals Biosciences 4-Aminophenol-d7 98 atom % D | 285132-88-9 | MFCD01074232 | 1G
4-Aminophenol-d7 98 atom % D | Mol Wt: 116.17 | 285132-88-9 | MFCD01074232 | 1G
