Aminophenols
Aobchem 3 5-Di-tert-butylbenzoic acid | ≥97% | CAS 16225-26-6 | C15H22O2 | 25g
3 5-Di-tert-butylbenzoic acid | ≥97% | CAS 16225-26-6 | C15H22O2 | 25g
Aobchem 1-Bromo-3 4-difluoro-2 5-dimethylbenzene | 95% | CAS 2969357-28-4 | C8H7BrF2 | 500mg
1-Bromo-3 4-difluoro-2 5-dimethylbenzene | 95% | CAS 2969357-28-4 | C8H7BrF2 | 500mg
Aobchem 1-Bromo-3 4-difluoro-2 5-dimethylbenzene | 95% | CAS 2969357-28-4 | C8H7BrF2 | 5g
1-Bromo-3 4-difluoro-2 5-dimethylbenzene | 95% | CAS 2969357-28-4 | C8H7BrF2 | 5g
Medchemexpress LLC SKI-178 | 1259484-97-3 | 99.3% | 50 MG
SKI-178 is a potent inhibitor of both sphingosine kinase-1 (SphK1) and sphingosine kinase-2 (SphK2). It demonstrates cytotoxicity in various cancer cell lines, including agent-sensitive and multi-agent resistant types, with IC50 concentrations ranging from 0.1 to 1.8 μM. This compound has been shown to induce apoptosis in human acute myeloid leukemia cell lines in a CDK1-dependent manner and correlates with prolonged Bcl-2 phosphorylation. In in-vivo studies, SKI-178 inhibited leukemic progression in the MLL-AF9 mouse model, leading to a decrease in white blood cell counts.
- Potent SphK1 and SphK2 inhibitor
- Exhibits cytotoxicity in various cancer cell lines
- Induces apoptosis in human acute myeloid leukemia cells
- Correlates with prolonged Bcl-2 phosphorylation
- Inhibits leukemic progression in MLL-AF9 mouse model
Medchemexpress LLC Guvacine hydrochloride | 6027-91-4 | MFCD00055191 | 99.9% | 163.60 g/mol | C6H10ClNO2 | 25 MG
Guvacine hydrochloride is the hydrochloride salt of guvacine, a pyridine alkaloid that acts as a GABA uptake inhibitor. Supplied as a high-purity research reagent, it is used in biochemical and neuropharmacological studies to probe GABA transporter activity. The substance is intended for laboratory research use only and is not for human or veterinary use.
- High purity (99.93%) for reliable experimental results.
- Molecular weight 163.60 g/mol.
- Molecular formula C6H10ClNO2.
- CAS number 6027-91-4 for unambiguous identification.
- Available in multiple pack sizes and solution formats for flexible use.
- Suitable for in vitro biochemical and pharmacology research.
Medchemexpress LLC MRE-269-d7 | 1265295-20-2 | 99.6% | C25H22D7N3O3 | 1 MG
MRE-269-d7 is a deuterium-labeled form of MRE-269. It functions as an active metabolite of selexipag and acts as a selective IP receptor agonist. Stable heavy isotopes, such as deuterium, are incorporated into drug molecules primarily as tracers for quantitative analysis during drug development. Deuteration can also impact the pharmacokinetic and metabolic profiles of drugs.
- This compound can be used as a tracer.
- It can be used as an internal standard for quantitative analysis.
- It is an isotope-labeled compound.
- It is suitable for use in in vivo cell experiments.
- It is useful for therapeutic drug monitoring.
Medchemexpress LLC HAIYPRH hydrochloride | 100.0% | 929.46 | 5 MG
HAIYPRH hydrochloride is a targeting ligand that specifically binds to the transferrin receptor (TfR). It can mediate the transport of nanocarriers across the blood-brain barrier.
- Can be conjugated to liposomes for ischemic stroke targeting treatment.
- Heptapeptide that can be used to target gliomas.
- Used as a ligand to target co-delivery systems to tumor cells expressing transferrin receptors.
- Modified co-delivery systems show higher efficiency in cellular uptake and gene expression in U87 MG cells.
- Modified co-delivery systems accumulate in tumors more efficiently in vivo.
Medchemexpress LLC G-5555 hydrochloride | 2319590-15-1 | 98.3% | 529.42 | 25 MG
G-5555 hydrochloride is a potent and selective p21-activated kinase 1 (PAK1) inhibitor with a Ki of 3.7 nM. This compound is intended for research use only.
- Potent and selective p21-activated kinase 1 (PAK1) inhibitor.
- Exhibits excellent kinase selectivity.
- Shows low blood clearance and acceptable half-life.
- Offers good oral exposure and high oral bioavailability.
- Demonstrates tumor growth inhibition in xenograft models.