Aminophenols
Medchemexpress LLC dTAGV-1 hydrochloride | 2624313-16-0 | 99.9% | C68H91ClN6O14S | 50 MG
dTAGV-1 hydrochloride is a potent and selective degrader of FKBP12F36V-tagged proteins PROTAC degrader. It can induce degradation of FKBP12F36V-Nluc in vivo.
- Target protein ligand
- Linker
- VHL ligand
- VHL ligand and linker
Medchemexpress LLC MRL-494 hydrochloride | 2699937-04-5 | 98.6% | 1 MG
MRL-494 hydrochloride is an antibacterial agent that functions as an inhibitor of β-barrel assembly machine A (BamA), remaining impervious to efflux and the outer membrane permeability barrier. It effectively inhibits both Gram-positive and Gram-negative bacteria by lethally disrupting the cytoplasmic membrane and inhibiting Outer Membrane Proteins (OMPs) biogenesis.
- Antibacterial agent
- Inhibitor of β-barrel assembly machine A (BamA)
- Impervious to efflux and the outer membrane permeability barrier
- Inhibits gram-positive bacteria
- Inhibits gram-negative bacteria
- Lethally disrupts the cytoplasmic membrane
- Inhibits outer membrane proteins (OMPs) biogenesis
Medchemexpress LLC SKI-178 | 1259484-97-3 | 99.29% | 100 MG
SKI-178 is a potent inhibitor of sphingosine kinase-1 (SphK1) and SphK2. It exhibits cytotoxicity at IC50 concentrations ranging from 0.1 to 1.8 μM in various cancer cell lines, including MTR3, NCI-ADR, and HL60/VCR cells. SKI-178 induces apoptosis in human acute myeloid leukemia cell lines in a CDK1-dependent manner and has been shown to inhibit leukemic progression in an MLL-AF9 mouse model.
- Potent inhibitor of sphingosine kinase-1 (SphK1) and SphK2
- Exhibits cytotoxicity in multiple cancer cell lines
- Induces apoptosis in human acute myeloid leukemia cell lines
- Inhibits leukemic progression in MLL-AF9 mouse model
- Purity of 99.29%
- Soluble in DMSO for in vitro experiments
- Formulations suitable for oral and intraperitoneal injection for in vivo studies
Medchemexpress LLC UNC9994 hydrochloride | 2108826-33-9 | 99.5% | 457.84 | 50 MG
UNC9994 hydrochloride | 2108826-33-9 | 99.5% | 457.84 | 50 MG
Medchemexpress LLC GSK2945 (hydrochloride) | 2517771-89-8 | 98.5% | 457.80 | 1 ML
GSK2945 hydrochloride is a tertiary amine and a highly specific Rev-erbα/REV-ERBα (mouse/human reverse erythroblastosis virus α) antagonist with EC50s of 21.5 μM and 20.8 μM, respectively. It enhances cholesterol 7α-hydroxylase (CYP7A1) levels and cholesterol metabolism. For research use only.
- Highly specific Rev-erbα/REV-ERBα antagonist.
- Enhances cholesterol 7α-hydroxylase (CYP7A1) levels.
- Promotes cholesterol metabolism.
- Suitable for research applications.
![Medchemexpress LLC 4-pyridinecarboxylic acid, 2-[[[2-[[2-(dimethylamino)ethyl]...]]-, hydrochloride | 3026728-26-4 | 96.6% | 25 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000231786.png-250.jpg)
Medchemexpress LLC 4-pyridinecarboxylic acid, 2-[[[2-[[2-(dimethylamino)ethyl]...]]-, hydrochloride | 3026728-26-4 | 96.6% | 25 MG
KDM5-C49 hydrochloride is a potent, selective inhibitor of KDM5 histone demethylases used for biochemical and cellular research, including cancer studies. It is supplied as a high-purity solid-liquid mixture with defined storage recommendations to maintain stability.
- Potent KDM5 inhibitor with reported IC50s of 40 nM (KDM5A), 160 nM (KDM5B), and 100 nM (KDM5C).
- High purity suitable for research applications.
- Molecular weight approximately 344.84 g/mol.
- Physical form: solid-liquid mixture, colorless to light yellow.
- Recommended storage: 4°C sealed; stock solutions: -80°C (up to 6 months) or -20°C (up to 1 month).
- Available in small milligram pack sizes for laboratory use.
Medchemexpress LLC PD153035 hydrochloride | 183322-45-4 | 99.5% | 50 MG
PD153035 hydrochloride is the hydrochloride salt of a potent epidermal growth factor receptor (EGFR) inhibitor used in biochemical and cellular research. It is supplied as a high-purity, well-characterized small-molecule reagent with defined solubility and storage recommendations.
- Potent EGFR inhibitor with reported Ki = 6 pM and IC50 = 25 pM.
- High purity: 99.48%.
- Molecular formula C16H15BrClN3O2; molecular weight 396.67 g/mol.
- Soluble in DMSO (4 mg/mL); insoluble in water (< 0.1 mg/mL).
- Recommended storage: solid at 4°C; in solution -80°C (6 months) or -20°C (1 month).
- Supplied as a 50 mg package for research use.
Medchemexpress LLC DiAzKs hydrochloride | 2421187-79-1 | 98.0% | 25 MG
DiAzKs (H-L-Photo-lysine) hydrochloride is a diazirine-containing lysine amino acid and a photo-cross-linker. It can be site-selectively incorporated into proteins and is utilized to crosslink protein-protein interactions both in vitro and in living cells. This compound functions as a UV light-activated photo-crosslinking probe. Photo-lysine, readily incorporated into proteins by native mammalian translation machinery, can be used to capture and identify proteins that recognize lysine post-translational modifications (PTMs), including 'readers' and 'erasers' of histone modifications.
- Functions as a UV light-activated photo-crosslinking probe
- Site-selectively incorporated into proteins
- Utilized to crosslink protein-protein interactions in vitro and in living cells
- Used to capture and identify proteins that recognize lysine post-translational modifications
Medchemexpress LLC MS8511 (hydrochloride) | 3031788-28-7 | C28H42ClN5O3 | 1 MG
MS8511 hydrochloride is a chemical compound for research use, identified as 2-Propenamide, N-[6-methoxy-4-[[1-(1-methylethyl)-4-piperidinyl]amino]-7-[3-(1-pyrrolidinyl)propoxy]-2-quinolinyl]-, hydrochloride (1:1). It appears as an off-white to light yellow solid and has a purity of 98.07% by LCMS. This product is intended for laboratory chemicals and manufacture of substances.
- For research use only
- Off-white to light yellow solid appearance
- Purity of 98.07%
- Stable under recommended storage conditions
- Recommended storage for powder: -20°C for 3 years
- Recommended storage for in solvent: -80°C for 6 months, -20°C for 1 month