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Filtered Search Results
Medchemexpress LLC Stem bromelain (EC 3.4.22.32) | 37189-34-7 | 25 G
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Stem bromelain (EC 3.4.22.32) is a cysteine protease and antibacterial agent isolated from pineapple (Ananas comosus), known for its fibrinolytic, anti-inflammatory, antitumor, and antimycobacterial activities.
- Cysteine protease and antibacterial agent.
- Induces secretion of IL-12p70 and IL-6.
- Promotes apoptosis, affects PARP, Caspase 3, 9, Bax, and Bcl-2.
- Fibrinolytic, antiedema, antithrombotic, and anti-inflammatory activities.
- Shows in vivo antitumor, antileukemic, and antimetastatic effects.
- Has antimycobacterial activity.
- Provides protection against lead poisoning.
- In vitro, causes apoptosis; increases CD80, CD86, IL-12p70, TNF-α, IL-6 in macrophages.
- In vivo, reduces lead accumulation in kidneys and spleen of lead-exposed Wistar rats.
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Medchemexpress LLC Cklf1-c19 | 960358-79-6 | 99.8% | 2225.54 | 1 MG
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CKLF1-C19 is the C-terminal peptide of human chemokine-like factor 1 (CKLF1). It interacts with CCR4 and inhibits chemotaxis induced by both CKLF1 and CCL17. CKLF1-C19 has demonstrated the ability to suppress allergic lung inflammation by inhibiting chemotaxis mediated by CCR3 and CCR4.
- Induces chemotactic migration of human Th2 cells at concentrations of 200 ng/mL or 500 ng/mL for 30 minutes.
- Inhibits CCL11-induced chemotaxis of mouse eosinophils and human CCR3-transfected or mouse CCR3-transfected HEK293 cells at 100 ng/mL for 30 minutes.
- A single intraperitoneal dose (0.01-100 μg, 200 μL) administered 30 minutes before OVA induction significantly reduces airway hyperresponsiveness (AHR) in comparison to the ovalbumin (OVA) group treated with saline.
- A single subcutaneous dose (0.5 mg or 1 mg, 200 μL) decreases CCL11-mediated recruitment of eosinophils into the peritoneal cavity in a mouse model of asthma.
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Cambridge Isotope Laboratories 4 4-DiBDE (BDE-15) (13C12 99%) 50 ug/mL in nonane 1 2 mL
4 4-DiBDE (BDE-15) (13C12 99%) 50 ug/mL in nonane 1 2 mL
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Medchemexpress LLC LR-90 | 245075-84-7 | 99.2% | C₃₅H₃₄Cl₂N₄O₈ | 1 ML
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LR-90 is an advanced glycation end product (AGE) inhibitor that has shown to inhibit inflammatory responses in human monocytes. It is also utilized in research concerning diabetic animal models.
- Inhibits AGE formation.
- Reduces inflammatory responses in human monocytes.
- Applicable in research related to diabetic animal models.
- Inhibits RAGE, MCP-1, COX-2, IP-10, and NOX2 mRNA expression in THP-1 cells.
- Blocks THP-1 cell adherence to endothelial cells.
- Has no significant effect on the viability of THP-1 cells at tested concentrations.
- Significantly reduces plasma lipids and modestly affects hyperglycemia in ZDF rats.
- Decreases renal AGE, AGER, and lipid peroxidation.
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Cambridge Isotope Laboratories PCN Cleanup Solution (13C10 99%) 200X stock in isooctane 1 2 mL
PCN Cleanup Solution (13C10 99%) 200X stock in isooctane 1 2 mL
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Medchemexpress LLC Urea, N-cyclopropyl-N'-[(3R)-1-[[5-(1-methylethyl)-1H-pyrazol-3-yl]carbonyl]-3-pyrrolidinyl | 3031476-73-7 | C15H23N5O2 | 25 MG
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Urea, N-cyclopropyl-N'-[(3R)-1-[[5-(1-methylethyl)-1H-pyrazol-3-yl]carbonyl]-3-pyrrolidinyl | 3031476-73-7 | C15H23N5O2 | 25 MG
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Medchemexpress LLC Verapamil EP Impurity C hydrochloride | 51012-67-0 | 99.6% | 245.75 | 1 ML
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Verapamil EP Impurity C hydrochloride, also known as NSC-609249 hydrochloride, is an impurity of Verapamil. Verapamil itself acts as a calcium channel blocker and a potent, orally active first-generation P-glycoprotein (P-gp) inhibitor. This product is intended for research use only.
- Impurity of Verapamil
- Related to a calcium channel blocker
- Related to a P-glycoprotein inhibitor
- For research use only
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Apexbio Technology LLC Chlorprothixene (hydrochloride) 6469-93-8 25g
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Chlorprothixene hydrochloride (CAS 6469-93-8) is a small-molecule antagonist targeting dopamine (D1 D2 D3 D5) and histamine H1 receptors It modulates neurotransmission by blocking these receptors thereby regulating dopaminergic and histaminergic pathways Chlorprothixene hydrochloride exerts its biological activity primarily through receptor antagonism In in vitro studies it demonstrates nanomolar affinity with Ki values of 18 nM (D1) 2 96 nM (D2) 4 56 nM (D3) 9 nM (D5) and 3 75 nM (H1) Additionally it reduces SARS-CoV viral replication (IC50 13 0 18 5 M depending on strain) Based on these pharmacological properties chlorprothixene hydrochloride holds research potential in antipsychotic therapy antiviral investigation and modulation of inflammation in cystic fibrosis models
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Medchemexpress LLC TNF RII/TNFRSF1B Mo 100ug
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Recombinant mouse TNF RII (TNFRSF1B) extracellular domain expressed in HEK293 cells with a C-terminal 6xHis tag, provided as purified protein for research use. It binds tumor necrosis factor-α and is used to study TNF signaling, receptor crosstalk, TRAF2 recruitment, and apoptosis pathways in vitro.
- Eukaryotic expression in HEK293 cells supports proper folding and post-translational modifications.
- C-terminal 6xHis tag enables facile purification and detection.
- High affinity for TNF-α, suitable for receptor binding studies.
- Useful in assays probing apoptosis and TNF receptor signaling.
- Provided for research use only; not for human or diagnostic use.
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Cambridge Isotope Laboratories JECS Labeled Mixture Solution in water (ultrapure) 1 2 mL
JECS Labeled Mixture Solution in water (ultrapure) 1 2 mL
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eMolecules 128-09-6 | N-Chlorosuccinimide | Oakwood Chemical | MFCD00005511 | 133.530 | C4H4ClNO2 | 99.000 | ClN1C(=O)CCC1=O | 1kg | 798923356
N-Chlorosuccinimide | Oakwood Chemical | 128-09-6 | MFCD00005511 | 133.530 | C4H4ClNO2 | 99.000 | ClN1C(=O)CCC1=O | 1kg | 798923356
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Medchemexpress LLC Etzadroxil 25g
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Etzadroxil (Ethyl 2-Ethylbutyrate) is a volatile ester compound Sulopenem Etzadroxil is an orally available ester proagent form of Sulopenem an antibiotic with broad-spectrum activities against Gram-positive and Gram-negative bacteria[1][2]
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Research Products International Corp 4NitroPhos bisCyclohexylam 25G
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Free PNP: <250ppm
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Medchemexpress LLC Iminostilbene | 256-96-2 | 25 G
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Iminostilbene, a chemical precursor of carbamazepine, is an orally active inhibitor of PKM2 (Pyruvate Kinase M2) and COX2 (Cyclooxygenase-2). It inhibits PKM2's interaction with HIF-1α and STAT3, reducing COX2 and iNOS expression. This suppresses macrophage-mediated inflammatory responses and improves myocardial ischemia/reperfusion (MI/R) injury, offering promise for research in inflammation regulation, cardiovascular, and macrophage-mediated immune-related diseases.
- Precursor of carbamazepine
- Orally active inhibitor of PKM2 and COX2
- Inhibits PKM2 and its interaction with HIF-1α and STAT3
- Reduces COX2 and iNOS expression
- Suppresses LPS-induced inflammatory cytokine release
- Suppresses macrophage-mediated inflammatory responses
- Improves myocardial ischemia/reperfusion (MI/R) injury
- Supports research in inflammation, cardiovascular, and immune-related diseases
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Medchemexpress LLC Apolipoprotein E/APO 100ug | 100ug
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Apolipoprotein E (APOE) plays a key role in lipoprotein-mediated lipid transport and is a core component in the production transformation and clearance of plasma lipoproteins As an amphipathic molecule APOE binds to various lipoprotein particles including chylomicrons chylomicron remnants VLDL and IDL favoring HDL Apolipoprotein E/APOE Protein Human (Biotinylated HEK293 His) is the recombinant human-derived Apolipoprotein E/APOE protein expressed by HEK293 with N-His labeled tag
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