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Filtered Search Results
Medchemexpress LLC Neratinib (maleate) | 915942-22-2 | 99.7% | 673.11 | 1 ML
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Neratinib (HKI-272) maleate is an orally available, irreversible, highly selective HER2 and EGFR inhibitor with IC50s of 59 nM and 92 nM, respectively. This product is for research use only.
- Inhibits HER2 and EGFR with IC50s of 59 nM and 92 nM.
- Shows anticancer activities against cancer cells expressing high levels of HER-2 or EGFR.
- Reduces tumor growth in a dose-dependent manner in various xenografts.
- Inhibits proliferation of cell lines with high HER-2 levels.
- Arrests cell cycle at G1-S phase in BT474 cells.
- Inhibits MAPK and Akt phosphorylation.
- Down-regulates cyclin D1 levels and induces p27.
- Inactive in MX-1 and MCF-7 xenografts.
- Inhibited phosphorylation of HER-2 in BT474 xenografts.
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Medchemexpress LLC WAY-100635 maleate | 1092679-51-0 | MFCD01321056 | 99.6% | 538.64 g·mol⁻¹ | C29H38N4O6 | 50 MG
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WAY-100635 maleate is the maleate salt of WAY-100635, a potent and selective 5-hydroxytryptamine 1A (5-HT1A) receptor antagonist used in pharmacological research. It is supplied as a high-purity solid for use in receptor binding and functional assays.
- Potent 5-HT1A antagonist with IC50 ~0.91 nM and Ki ~0.39 nM.
- High purity, typically ≥99.5% by supplier analysis.
- White to off-white solid suitable for formulation and assay work.
- High solubility in DMSO; aqueous solutions may require sonication or warming.
- Stable when sealed and stored cold; long-term solvent storage at -80°C is recommended.
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Medchemexpress LLC Filgotinib maleate | 1802998-75-9 | MFCD34184747 | 99.9% | 541.58 | C25H27N5O7S | 10 MG
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Filgotinib maleate is the maleate salt of filgotinib, a selective, orally active JAK1 inhibitor supplied as a high-purity research reagent for studying inflammatory and antiviral pathways. Provided as a 10 mg solid, it is intended for laboratory use with recommended storage conditions noted on the product datasheet and SDS.
- Selective JAK1 inhibitor for research applications.
- Maleate salt form for improved solubility.
- High purity suitable for analytical and biological studies.
- 10 mg solid package convenient for small-scale experiments.
- Recommended storage: solid 4°C; in solvent -80°C up to 6 months.
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Medchemexpress LLC Asenapine maleate | 85650-56-2 | 99.95% | 401.84 | 10 MG
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Asenapine maleate, also known by its synonym Org 5222 maleate, is a brain-penetrant atypical antipsychotic. It acts as an antagonist for various receptors, including serotonin, adrenoceptors, dopamine, and histamine receptors. It is investigated for its potential in treating schizophrenia and bipolar disorder.
- Acts as an antagonist of serotonin receptors.
- Exhibits antagonism towards adrenoceptors.
- Functions as a dopamine receptor antagonist.
- Blocks histamine receptors.
- Investigated for its use in schizophrenia.
- Studied for application in bipolar disorder.
- May offer superior therapeutic effects on anxiety symptoms.
- Demonstrates anxiolytic-like effects in behavioral tests in mice.
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TARGETMOL CHEMICALS INC Prochlorperazine Maleate 200MG
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Also available in 1 mL, 25 mg, 50 mg, 100 mg, 500 mg and bulk. Please contact Fisher for quotes. Prochlorperazine Maleate (Capazine) is a phenothiazine antipsychotic used principally in the treatment of NAUSEA; VOMITING; and VERTIGO. It is more likely than CHLORPROMAZINE to cause EXTRAPYRAMIDAL DISORDERS. Purity 99.99%
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Medchemexpress LLC AZD9496 | 1639042-08-2 | 10 MG
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AZD9496 is an orally active, selective estrogen receptor degrader (SERD) and an effective, selective estrogen receptor (ERα) antagonist. It demonstrates high potency with an IC50 of 0.28 nM for ERα antagonism and significantly inhibits MCF-7 cell growth.
- Orally active, selective estrogen receptor degrader (SERD)
- Effective and selective estrogen receptor (ERα) antagonist
- IC50 of 0.28 nM for ERα antagonism
- Inhibits MCF-7 cell growth with an EC50 of 0.04 nM
- High selectivity over other nuclear hormone receptors
- Shows significant tumor growth inhibition in estrogen-dependent MCF-7 xenograft models
- Leads to further growth-inhibitory effects when combined with PI3K pathway and CDK4/6 inhibitors
- Demonstrates significant activity in long-term estrogen-deprived models
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Sigma Aldrich Fine Chemicals Biosciences Sodium sulfite puriss., meets analytical specification of Ph. Eur., BP, NF, anhydrous, 95.0-100.0% (iodometric) | 7757-83-7 | MFCD00003503 | 1KG
Sodium sulfite puriss., meets analytical specification of Ph. Eur., BP, NF, anhydrous, 95.0-100.0% (iodometric) | Purity: 95.0-100.0% (iodometric) | Mol Wt: 126.04 | 7757-83-7 | MFCD00003503 | 1KG
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eMolecules EMOLECULES INC
5000471967 METHYL PROPIOLATE 25G
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Chemscene CHEMSCENE
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5000578156 TERT-BUTYL PROPIOLATE 1G
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Chemscene CHEMSCENE
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5000579944 DIETHYL MALEATE 100G
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000586278 MEPYRAMINE MALEATE 1G
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Selleck Chemical LLC Pixantrone Maleate S5059-10mg
Pixantrone (BBR-2778) is a novel aza-anthracenedione compound with antitumor activity It is a weak topoisomerase II inhibitor and forms stable DNA adducts through alkylation with specificity for DNA hypermethylated sites
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Sigma Aldrich Fine Chemicals Biosciences SIGMA ALDRICH FINE CHEMICALS BIOSCIENCES
NC3904409 VINYL CROTONATE
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eMolecules Medchem Express / VUF11207 (fumarate) / 5mg / 515743918 / HY-110318 / / 1785665-61-3 / MFCD27991278 / 586.657 / C31H39FN2O8
Medchem Express / VUF11207 (fumarate) / 5mg / 515743918 / HY-110318 / / 1785665-61-3 / MFCD27991278 / 586.657 / C31H39FN2O8
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Medchemexpress LLC Cipralisant maleate 50mg | 223420-20-0 | 50MG
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Cipralisant (GT-2331) (maleate) is an orally active low-toxicity potent selective high affinity histamine H3 receptor full antagonist in vivo and an agonist in vitro with a pKi of 9 9 for histamine H3 receptor and a Ki of 0 47 nM for rat histamine H3 receptor Cipralisant (maleate) has the potential for attention-deficit hyperactivity disorder research[1 [2 [3 [4 Cipralisant (maleate) is a click chemistry reagent it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups
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