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Filtered Search Results
Medchemexpress LLC Monomethylauristatin F hydrochloride | 1415246-68-2 | 768.42 | C39H66ClN5O8 | 50 MG
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MMAF hydrochloride (Monomethylauristatin F hydrochloride) is a potent tubulin polymerization inhibitor used as an antitumor agent and as the cytotoxic payload in antibody-drug conjugates (ADCs). It is supplied in small milligram-scale amounts for research and ADC development.
- Potent tubulin polymerization inhibitor.
- Used as a cytotoxic component in ADCs.
- CAS number 1415246-68-2.
- Molecular weight 768.42.
- Chemical formula C39H66ClN5O8.
- Supplied as a solid in milligram quantities for research use.
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eMolecules 10250-61-0 | 1,5-Dimethyl-1H-pyrazole-3-carboxylic acid methyl ester | Chem-Impex | MFCD06661312 | 154.169 | C7H10N2O2 | 99.000 | COC(=O)c1cc(C)n(C)n1 | 1g | 386899433
1,5-Dimethyl-1H-pyrazole-3-carboxylic acid methyl ester | Chem-Impex | 10250-61-0 | MFCD06661312 | 154.169 | C7H10N2O2 | 99.000 | COC(=O)c1cc(C)n(C)n1 | 1g | 386899433
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Medchemexpress LLC Z-WEHD-FMK | 210345-00-9 | 98.0% | 763.77 | 5 MG
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Z-WEHD-FMK is a potent, cell-permeable, and irreversible caspase-1/5 inhibitor. It also shows a robust inhibitory effect on cathepsin B activity (IC50=6 μM).
- Blocks C. trachomatis-induced cleavage of golgin-84 and increases GM130 expression in cells.
- Inhibits E. piscicida-induced ZF4 cell cytotoxicity and pyroptotic morphology.
- Inhibits cytotoxicity induced by cytosolic LPS delivery.
- Reduces IL-1β release in bone marrow-derived macrophages (BMDM) depending on metal ion concentration.
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![eMolecules 5-Norbornene-2,2-dimethanol | Combi-Blocks |154.209 | C9H14O2 | 95.000 | OCC1(CO)C[C@@H]2C[C@H]1C=C2 | 1g | 401042964](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502189765.JPG-250.jpg)
eMolecules 5-Norbornene-2,2-dimethanol | Combi-Blocks |154.209 | C9H14O2 | 95.000 | OCC1(CO)C[C@@H]2C[C@H]1C=C2 | 1g | 401042964
5-Norbornene-2,2-dimethanol | Combi-Blocks |154.209 | C9H14O2 | 95.000 | OCC1(CO)C[C@@H]2C[C@H]1C=C2 | 1g | 401042964
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![Medchemexpress LLC [4-hydroxy-2-(2-hydroxyphenyl)-1,3-thiazol-5-yl]-(1,2-oxazolidin-2-yl)methanone | 2102179-29-1 | MFCD34602961 | 99.5% | 292.31 g/mol | C13H12N2O4S | 5 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/default.jpg-250.jpg)
Medchemexpress LLC [4-hydroxy-2-(2-hydroxyphenyl)-1,3-thiazol-5-yl]-(1,2-oxazolidin-2-yl)methanone | 2102179-29-1 | MFCD34602961 | 99.5% | 292.31 g/mol | C13H12N2O4S | 5 MG
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TRPM8 antagonist 3 is a novel, potent small-molecule blocker of the TRPM8 ion channel with a reported IC50 of 11 nM. Supplied as a solid (off-white to light yellow), it is intended for research use and is characterized by high purity and defined storage conditions.
- Potent TRPM8 inhibition (IC50 11 nM).
- High purity (≈99.5%).
- Chemical formula C13H12N2O4S; molecular weight 292.31 g/mol.
- Supplied as an off-white to light yellow solid.
- Powder stable at -20°C for up to 3 years; solvent stability documented.
- Available in multiple package sizes and as a 10 mM solution in DMSO.
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Medchemexpress LLC BET bromodomain inhibitor 1 | 2411226-02-1 | 99.7% | 100 MG
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BET bromodomain inhibitor 1 is an orally active, selective bromodomain and extra-terminal (BET) bromodomain inhibitor with an IC50 of 2.6 nM for BRD4. It binds to BRD2(2), BRD3(2), BRD4(1), BRD4(2), and BRDT(2) with high affinities (Kd values of 1.3 nM, 1.0 nM, 3.0 nM, 1.6 nM, 2.1 nM, respectively). This inhibitor demonstrates anti-cancer activity.
- Orally active, selective BET bromodomain inhibitor
- High affinity binding to BRD proteins (BRD2(2), BRD3(2), BRD4(1), BRD4(2), BRDT(2))
- Demonstrates anti-cancer activity
- Excellent selectivity for BET bromodomain family
- Does not inhibit five cytochrome P450 enzymes
- Inhibits growth of acute myeloid leukemia and multiple myeloma cell lines
- Exhibits strong antitumor activities in vivo
- Induces G1-phase cell cycle arrest
- Dose-dependent inhibition of c-Myc and upregulation of p21
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(CCC(C)(C)O)C(=O)O[C@H]1[C@H]2c3cc4OCOc4cc3CCN3CCC[C@]23C=C1OC | 250mg | 603142371](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502191382.JPG-250.jpg)
eMolecules 26833-85-2 | Harringtonine | Combi-Blocks, Inc. | MFCD28978177 | 531.602 | C28H37NO9 | 96.000 | COC(=O)C[C@](O)(CCC(C)(C)O)C(=O)O[C@H]1[C@H]2c3cc4OCOc4cc3CCN3CCC[C@]23C=C1OC | 250mg | 603142371
Harringtonine | Combi-Blocks, Inc. | 26833-85-2 | MFCD28978177 | 531.602 | C28H37NO9 | 96.000 | COC(=O)C[C@](O)(CCC(C)(C)O)C(=O)O[C@H]1[C@H]2c3cc4OCOc4cc3CCN3CCC[C@]23C=C1OC | 250mg | 603142371
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Matrix Scientific METHYL 1H-PYRAZOLE-3-CARBOXYLATE MF C5H6N2O2 MW 126.12 CAS 15366-34-4 MDL MFCD00649381 QTY 1 UOM G
METHYL 1H-PYRAZOLE-3-CARBOXYLATE MF C5H6N2O2 MW 126.12 CAS 15366-34-4 MDL MFCD00649381 QTY 1 UOM G
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eMolecules 2090332-56-0 | methyl 1-amino-6-bromoisoquinoline-4-carboxylate | Synthonix281.109 | C11H9BrN2O2 | 95.000 | COC(=O)c1cnc(N)c2ccc(Br)cc12 | 250mg | 779537019
methyl 1-amino-6-bromoisoquinoline-4-carboxylate | Synthonix | 2090332-56-0281.109 | C11H9BrN2O2 | 95.000 | COC(=O)c1cnc(N)c2ccc(Br)cc12 | 250mg | 779537019
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eMolecules 53673-40-8 | 1-(2-AMINOETHYL)-3-ISOPROPYLUREA | AstaTech | MFCD09998224 | 145.206 | C6H15N3O | 95.000 | CC(C)NC(=O)NCCN | 1g | 112531466
1-(2-AMINOETHYL)-3-ISOPROPYLUREA | AstaTech | 53673-40-8 | MFCD09998224 | 145.206 | C6H15N3O | 95.000 | CC(C)NC(=O)NCCN | 1g | 112531466
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![Medchemexpress LLC Methyl 5-[benzylsulfonyl-...]-2-[(4-methylphenyl)methoxy]benzoate | 1919853-46-5 | MFCD31382181 | 99.9% | 680.79 | C34H36N2O9S2 | 25 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000215068.png-250.jpg)
Medchemexpress LLC Methyl 5-[benzylsulfonyl-...]-2-[(4-methylphenyl)methoxy]benzoate | 1919853-46-5 | MFCD31382181 | 99.9% | 680.79 | C34H36N2O9S2 | 25 MG
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PTP1B-IN-2 is a potent small-molecule inhibitor of protein tyrosine phosphatase 1B (PTP1B) that potently inhibits the target (IC50 = 50 nM) and demonstrates cellular activity by enhancing insulin receptor β phosphorylation and increasing insulin-stimulated glucose uptake in muscle cells.
- Potent PTP1B inhibition (IC50 50 nM).
- High selectivity versus SHP-2 and LAR (>40-fold).
- Improved selectivity versus TCPTP (~15-fold).
- Enhances insulin-mediated IRβ phosphorylation in cells.
- Increases insulin-stimulated glucose uptake in L6 myotubes.
- High purity suitable for research use (≈99.9%).
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Cayman Chemical CA-074 methyl ester, Purity: ≥98%, CAS: 147859-80-1, 1 mg
A cell-permeable inhibitor of cathepsin B and L in vivo and in whole cells; used to study the role of cathepsin B in neurodegeneration, cancer cell metastasis, necrosis, and rheumatoid arthritis
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Medchemexpress LLC HY-100350 1mg Medchemexpress, CA-074 methyl ester CAS:147859-80-1 Purity:>98%
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Medchemexpress, HY-100350 1mg CA-074 methyl ester CAS:147859-80-1 CA-074 methyl ester is a specific inhibitor of Cathepsin B , which has potent bioactivities such as neuroprotective, anti-cancer, and anti-inflamatory effects. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
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MEDCHEMEXPRESS LLC TRPM8 ANTAGONIST 5MG
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501872390 TRPM8 ANTAGONIST 5MG
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MEDCHEMEXPRESS LLC MS417 5MG
Small and Specialty Supplier Partner
Small and/or specialty supplier based on Federal laws and SBA requirements.
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Small and/or specialty supplier based on Federal laws and SBA requirements.
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501872303 MS417 5MG
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
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