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Filtered Search Results
Medchemexpress LLC Cediranib maleate | 857036-77-2 | 99.95% | 100 MG
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Cediranib maleate is a highly potent, orally available VEGFR inhibitor. It inhibits VEGF-stimulated proliferation and KDR phosphorylation, reducing vessel area, length, and branching. It ablates experimental angiogenesis and inhibits endochondral ossification and corpora luteal development. It also inhibits the growth of established human tumor xenografts in athymic mice, showing a reduction in microvessel density within tumors.
- Highly potent, orally available VEGFR inhibitor
- Inhibits VEGF-stimulated proliferation and KDR phosphorylation
- Reduces vessel area, length, and branching
- Ablates experimental angiogenesis
- Inhibits endochondral ossification and corpora luteal development
- Inhibits growth of established human tumor xenografts
- Reduces microvessel density within tumors
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eMolecules 2828446-92-8 | Ambeed | 2-(((tert-Butyldimethylsilyl)oxy)methyl)-5-(4455-tetramethyl-132-dioxaborolan-2-yl)thiazole | 100mg | 491657158 | A307802 | MFCD19689425 | 355.38 | C16H30BNO3SSi
Ambeed | 1-Methyl-2-oxo-12-dihydropyridine-4-carbonitrile | 100mg | 518523937 | A126143 | 70411-83-5 | MFCD27923636 | 134.138 | C7H6N2O
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Apexbio Technology LLC NB-598 Maleate 155294-62-5 50mg
NB-598 Maleate is a small-molecule inhibitor targeting squalene epoxidase (SE) an essential enzyme in cholesterol biosynthesis It is designed to inhibit SE thereby disrupting the oxygenation of squalene and affecting downstream synthesis of cholesterol intermediates particularly within farnesol-dependent pathways leading to triglyceride biosynthesis NB-598 Maleate exerts its biological activity primarily through inhibition of squalene epoxidase In mouse pancreatic islet models NB-598 Maleate reduces insulin secretion under both basal and glucose-stimulated conditions Additionally this compound inhibits calcium voltage-dependent (CaV) ion channels in cellular assays Based on these pharmacological properties NB-598 Maleate holds research potential in studying cholesterol biosynthesis pathways lipid metabolism insulin regulation and the physiological role of CaV channels
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Apexbio Technology LLC Flupirtine maleate 75507-68-5 100mg
Flupirtine maleate (CAS 75507-68-5) is a non-opioid analgesic compound characterized by its modulatory effects on neuronal excitability It acts primarily by opening neuronal potassium channels leading to membrane stabilization and reduced excitatory neurotransmission Additionally flupirtine exerts indirect antagonism of N-methyl-D-aspartate (NMDA) receptors which contributes to its analgesic and muscle relaxant effects Due to this dual mechanism flupirtine maleate is utilized in research focusing on pain modulation neuroprotection and the investigation of NMDA receptor-mediated pathways
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Medchemexpress LLC Avitinib maleate | 1557268-88-8 | 99.9% | 603.60 | 25 MG
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Avitinib maleate is a third-generation, irreversible, and orally active selective EGFR inhibitor. It has IC50 values of 0.18 nM against both EGFR L858R and EGFR T790M, and 7.68 nM against wild-type EGFR. It is also a BTK inhibitor, inducing apoptosis and inhibiting BTK phosphorylation in mantle cell lymphoma. It exhibits anticancer effects.
- Third-generation, irreversible, and orally active selective EGFR inhibitor.
- Potent against EGFR L858R, EGFR T790M, and wild-type EGFR.
- BTK inhibitor.
- Induces apoptosis.
- Inhibits phosphorylation of BTK in mantle cell lymphoma.
- Exhibits anticancer effects.
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eMolecules 217300-17-9 | Ambeed | (Triisopropylsiloxy)methyl chloride | 100mg | 589771798 | A991979 | MFCD05865265 | 222.83 | C10H23ClOSi
ChemScene | Imidazo[12-a]pyrimidin-7-amine | 25mg | 801475938 | CS-0094347 | 462651-80-5 | MFCD09909665 | 134.142 | C6H6N4
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Medchemexpress LLC Setiptiline maleate | 85650-57-3 | 99.9% | 377.43 | 50 MG
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Setiptiline maleate is a serotonin receptor antagonist and a tetracyclic antidepressant (TeCA) that acts as a noradrenergic and specific serotonergic antidepressant (NaSSA).
- Functions as a norepinephrine reuptake inhibitor.
- Acts as an α2-adrenergic receptor antagonist.
- Serves as a serotonin receptor antagonist, targeting 5-HT2A, 5-HT2C, and/or 5-HT3 subtypes.
- Acts as an H1 receptor inverse agonist/antihistamine.
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TARGETMOL CHEMICALS INC ACEPROMAZINE MALEATE 50MG
Also available in 5 mg 10 mg 25 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. ACEPROMAZINE MALEATE is a dopamine receptor antagonistpurity: 99%
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AdipoGen Fluorescein diacetate
Chemical. CAS 596-09-8. Formula C24H16O7. MW 416.38. Synthetic. FDA is a non-fluorescent hydrophobic fluorescein derivative that can pass through the cell membrane whereupon intracellular esterases hydrolyze the diacetate group producing the highly fluorescent product fluorescein. The fluorescein molecules accumulate in cells that possess intact membranes so the green fluorescence can be used as a marker of cell viability. Cells that do not possess an intact cell membrane or an active metabolism may not accumulate the fluorescent product and therefore do not exhibit green fluorescence. FDA may be used in combination with PI staining as the non-viable cells take up the PI and stain dead cells red whereas viable cells do not take up the PI and should only stain green. This 2-color separation of non-viable and viable cells may provide a more accurate quantitation of cell viability than single color analysis.
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Cayman Chemical Fluorescein diacetate, Purity: ≥98%, CAS: 596-09-8, 5 g
A cell-permeable fluorogenic cell viability probe; cleaved by intracellular esterases to produce fluorescein which displays excitation/emission maxima of 490/520 nm, respectively
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AdipoGen Naphtholfluorescein diacetate
Chemical. CAS 77084-71-0. Formula C32H20O7. Molecular Weight 516.5. Naphthofluorescein-diacetate is a non-fluoresent compound that is hydrolyzed by esterases to the fluorescent compound Naphthofluorescein. Spectral data lambdaex 594 nm lambdaem 663 nm in 0.1 M Tris pH 9.0 esterase. The fluorescent naphthofluorescein has been shown to be an inhibitor of furin.
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Selleck Chemical LLC Ethynodiol diacetate S3160-50mg
Ethynodiol diacetate (8080 CB Ethynodiol acetate) is one of the first synthetic progestogens used in contraceptive pills
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Sigma Aldrich Fine Chemicals Biosciences Methyl 2-oxobutanoate 95% | 3952-66-7 | MFCD03093092 | 25G
Methyl 2-oxobutanoate 95% | Purity: >=95.0% (GC); 95% | Mol Wt: 116.12 | 3952-66-7 | MFCD03093092 | 25G
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Medchemexpress LLC HY-13324 50mg Medchemexpress, Bardoxolone methyl CAS:218600-53-4 Purity:>98%
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Medchemexpress, HY-13324 50mg Bardoxolone methyl CAS:218600-53-4 Bardoxolone methyl (NSC 713200; RTA 402; CDDO Methyl ester) is a synthetic triterpenoid compound with potential antineoplastic and anti-inflammatory activities, acting as an activator of the Nrf2 pathway and an inhibitor of the NF-κB pathway. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
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eMolecules 1604-11-1 | Dimethyl methylsuccinate | Combi-Blocks | MFCD00008449 | 160.169 | C7H12O4 | 95.000 | COC(=O)CC(C)C(=O)OC | 25g | 482934781
Dimethyl methylsuccinate | Combi-Blocks | 1604-11-1 | MFCD00008449 | 160.169 | C7H12O4 | 95.000 | COC(=O)CC(C)C(=O)OC | 25g | 482934781
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