Thiazoles
Medchemexpress LLC AGI-5198 | 1355326-35-0 | 99.9% | 462.56 | 5 MG
AGI-5198 (IDH-C35) is a potent and selective mutant IDH1R132H inhibitor with an IC50 of 0.07 μM. It causes 50 to 60% growth inhibition of human glioma xenografts and does not affect the growth of IDH1 wild-type glioma xenografts. This compound reverses the effects of ionizing radiation (IR) on IDH1(R132H) mutated cancer cells, leading to higher levels of reactive oxygen species, DNA double-strand breaks, and cell death.
- Potent and selective mutant IDH1R132H inhibitor.
- Causes 50 to 60% growth inhibition of human glioma xenografts.
- Does not affect the growth of IDH1 wild-type glioma xenografts.
- Reverses the effects of ionizing radiation (IR) on IDH1(R132H) mutated cancer cells, leading to higher levels of reactive oxygen species, DNA double-strand breaks, and cell death.
Apexbio Technology LLC MTT Cell Proliferation Assay Kit 500T
MTT Cell Proliferation Assay Kit is a colorimetric assay designed to quantify cell viability proliferation or cytotoxicity in mammalian cell cultures by measuring metabolic activity The kit exerts its biological activity through the enzymatic reduction of the tetrazolium dye MTT by actively respiring mitochondria in viable cells leading to the formation of insoluble purple formazan crystals The amount of formazan produced correlates with cellular metabolic activity Based on these properties MTT Cell Proliferation Assay Kit holds research potential in pharmaceutical screening toxicity testing oncology and cell biology research
Apexbio Technology LLC MTT Cell Proliferation Assay Kit 2500T
MTT Cell Proliferation Assay Kit is a colorimetric assay designed to quantify cell viability proliferation or cytotoxicity in mammalian cell cultures by measuring metabolic activity The kit exerts its biological activity through the enzymatic reduction of the tetrazolium dye MTT by actively respiring mitochondria in viable cells leading to the formation of insoluble purple formazan crystals The amount of formazan produced correlates with cellular metabolic activity Based on these properties MTT Cell Proliferation Assay Kit holds research potential in pharmaceutical screening toxicity testing oncology and cell biology research
Medchemexpress LLC 2,4-Dimethylthiazole-5-carboxylic acid | 53137-27-2 | MFCD00052943 | 157.19 | 500 MG
2,4-Dimethylthiazole-5-carboxylic acid is a versatile building block utilized in chemical synthesis, particularly for drug discovery and the development of pharmaceuticals and agrochemicals. Its unique thiazole structure imparts significant functionality, enabling the modification of lead compounds and the enhancement of biological activity. It is suitable for research use only.
- Used as a heterocyclic building block
- Enhances biological activity in compounds
- Important in pharmaceutical and agrochemical synthesis
- Applicable in the flavoring and fragrance industries
- Contributes to advancements in medicinal chemistry and agricultural science
Apexbio Technology LLC YL-109 36341-25-0 10mM (in 1mL DMSO)
YL-109 (CAS 36341-25-0) is a small molecule with demonstrated antitumor properties primarily acting through modulation of the aryl hydrocarbon receptor (AhR) signaling pathway This compound enhances expression of the molecular chaperone-associated ubiquitin ligase CHIP (C-terminus of Hsp70-interacting protein) leading to downstream regulation of processes implicated in cell proliferation and invasion In breast cancer models YL-109 induces CHIP expression resulting in suppressed proliferation and invasive capabilities of cancer cells YL-109 is thus a valuable tool for investigating AhR-mediated anticancer mechanisms and exploring therapeutic strategies in breast cancer research
Apexbio Technology LLC YL-109 36341-25-0 10mg
YL-109 (CAS 36341-25-0) is a small molecule with demonstrated antitumor properties primarily acting through modulation of the aryl hydrocarbon receptor (AhR) signaling pathway This compound enhances expression of the molecular chaperone-associated ubiquitin ligase CHIP (C-terminus of Hsp70-interacting protein) leading to downstream regulation of processes implicated in cell proliferation and invasion In breast cancer models YL-109 induces CHIP expression resulting in suppressed proliferation and invasive capabilities of cancer cells YL-109 is thus a valuable tool for investigating AhR-mediated anticancer mechanisms and exploring therapeutic strategies in breast cancer research
![Medchemexpress LLC [Sar9,Met(O2)11]-Substance P | 110880-55-2 | 99.6% | 1393.66 | 5 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000424719.png-250.jpg)
Medchemexpress LLC [Sar9,Met(O2)11]-Substance P | 110880-55-2 | 99.6% | 1393.66 | 5 MG
[Sar9,Met(O2)11]-Substance P is a tachykinin NK1 receptor selective agonist.
- High purity: 99.6%
- Appearance: White to off-white solid
- Molecular weight: 1393.66
- Soluble in H2O and PBS at 100 mg/mL with sonication
- Powder stability: 2 years at -80°C, 1 year at -20°C (sealed, away from moisture)
- In-solvent stability: 6 months at -80°C, 1 month at -20°C (sealed, away from moisture)
- Targets NK1 receptor with an IC50 of 1.1 x 10-10 M in human U373MG cells
Medchemexpress LLC KL-11743 | 1369452-53-8 | 99.4% | C30H30N6O3 | 50 MG
KL-11743 is a potent, orally active, and glucose-competitive inhibitor of class I glucose transporters (GLUT1, GLUT2, GLUT3, and GLUT4). It blocks glucose metabolism and can synergize with electron transport inhibitors to induce cell death. Additionally, KL-11743 induces the formation of disulfide bonds in actin cytoskeletal proteins, leading to cellular disulfidptosis.
- Potent, orally active, and glucose-competitive inhibitor of class I glucose transporters
- Blocks glucose metabolism and synergizes with electron transport inhibitors to induce cell death
- Induces cellular disulfidptosis
- Inhibits the growth of various cancer cell lines in vitro
- Effective in decreasing tumor growth in animal models
Medchemexpress LLC HZX-02-059 | 2240205-30-3 | 99.4% | 487.48 | 25 MG
HZX-02-059 is a potent methuosis inducer and dual-target PIKfyve/tubulin inhibitor with anticancer activity. It primarily disrupts the balance of endocytosis and exocytosis, leading to the formation of numerous vesicles and inducing cell death. This compound also induces cell vacuolization, promotes apoptosis, downregulates the p53 pathway, inhibits PI3K/AKT phosphorylation, and suppresses c-Myc and NF-κB transcription.
- Potent methuosis inducer
- Dual-target PIKfyve/tubulin inhibitor
- Anticancer activity
- Induces cell vacuolization
- Promotes apoptosis
- Downregulates the p53 pathway
- Inhibits PI3K/AKT phosphorylation
- Inhibits c-Myc and NF-κB transcription
- Broad spectrum of cytotoxicity against various human cancer cell lines
Medchemexpress LLC Phospho-JNK1/2/3 (Thr183) Antibody | 100 UL
Phospho-JNK1/2/3 (Thr183) Antibody is a rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to Phospho-JNK1/2/3 (Thr183). It is for research use only and not sold to patients.
- Host: Rabbit
- Clonality: Polyclonal
- Species reactivity: Human, mouse, rat
- Immunogen: Synthetic phosphopeptide (Thr183)
- Applications: WB (1:500-1:1000), IHC-P (1:50-1:100), ICC/IF (1:50-1:200), IP (1:20), FC (1:50-1:100)
- Sensitivity: Endogenous
- Purity: Affinity purified
- Conjugation: Non-conjugated
- Modification: Phosphorylated
- Isotype: IgG
- Appearance: Liquid
- Formulation: Rabbit IgG in PBS, 0.05% BSA, 0.02% sodium azide, 50% glycerol
- Storage and stability: Stored at -20°C for 1 year, avoid repeated freeze/thaw cycles