BioCore HIC is a family of high-performance, hydrophobic interaction chromatography columns designed for Drug-Antibody-Ratio (DAR) determination in Antibody-Drug Conjugates (ADCs) based on their differences in surface hydrophobicity. This column technology involves the creation of a hydrophilic layer decorated with selective hydrophobic functionality, on the surface of monodispersed, wide-pore, spherical, silica particles, combined with well-established column packing processes. BioCore HIC-Butyl and BioCore HIC-Phenyl offer different retention and selectivity.