ELISA Substrates and Reagents
Sigma Aldrich Fine Chemicals Biosciences MAP Kinase 2/Erk2 Protein
N-terminal GST tagged recombinant full-length human MAP Kinase 2/Erk2 Activated with MEK1 (14-429).
American Research Products Inc Mouse Heat shock protein HSP 9
Mouse Heat shock protein HSP 90-beta (HSP90AB1) ELISA kit from CUSABIO Detection Range 15 6 pg/mL-1000 pg/mL Sensitivity 3 9 pg/mL Sample serum plasma tissue homogenates cell lysates Method Sandwich
ABclonal Technology Phospho-SnRK2.6-S175 pAb
Activator of the abscisic acid (ABA) signaling pathway that regulates numerous ABA responses, such as stomata closure in response to drought, darkness, high CO2, plant pathogens, or decreases in atmospheric relative humidity (RH) (PubMed30361234).
Cayman Chemical PAD Stop SolutIon 1ea
A negative modulator of mitochondrial calcium uptake selectively decreases mitochondrial over cytosolic histamine-induced calcium uptake but also decreases the mitochondrial membrane potential in HeLa cells at 10 UM binds to Micu1 in a cell-free assay (Kd 8.4 UM for the mouse protein) decreases myotube width in differentiated C2C12 skeletal muscle myoblasts in an in vitro model of myotube growth protects against ferroptosis induced by RSL3 erastin or glutamate in HT22 hippocampal cells at 2.5 UM
ABclonal Technology Phospho-RELB-S573 Rabbit pAb
Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and protein kinase binding activity. Involved in lymphocyte differentiation and negative regulation of interferon-beta production. Located in cytosol and nucleoplasm. Part of chromatin, nucleus, and transcription repressor complex. Colocalizes with centrosome. Implicated in breast cancer and immunodeficiency 53. Biomarker of breast cancer and transitional cell carcinoma.
ABclonal Technology Phospho-MARCKS-S162 Rabbit pAb
The protein encoded by this gene is a substrate for protein kinase C. It is localized to the plasma membrane and is an actin filament crosslinking protein. Phosphorylation by protein kinase C or binding to calcium-calmodulin inhibits its association with actin and with the plasma membrane, leading to its presence in the cytoplasm. The protein is thought to be involved in cell motility, phagocytosis, membrane trafficking and mitogenesis.
ABclonal Technology phospho-LATS1-S909/LATS2-S872 Rabbit pAb
The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments.
ABclonal Technology Phospho-ERK1-T202 + ERK2-T185 Rabbit pAb
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act in a signaling cascade that regulates various cellular processes such as proliferation, differentiation, and cell cycle progression in response to a variety of extracellular signals. This kinase is activated by upstream kinases, resulting in its translocation to the nucleus where it phosphorylates nuclear targets. Alternatively spliced transcript variants encoding different protein isoforms have been described.
ABclonal Technology Phospho-PFKFB2-S483 Rabbit pAb
The protein encoded by this gene is involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls glycolysis in eukaryotes. The encoded protein has a 6-phosphofructo-2-kinase activity that catalyzes the synthesis of fructose-2,6-bisphosphate, and a fructose-2,6-biphosphatase activity that catalyzes the degradation of fructose-2,6-bisphosphate. This protein regulates fructose-2,6-bisphosphate levels in the heart, while a related enzyme encoded by a different gene regulates fructose-2,6-bisphosphate levels in the liver and muscle. This enzyme functions as a homodimer. Two transcript variants encoding two different isoforms have been found for this gene.