Process Flow Controllers
Selleck Chemical LLC ARS-853
ARS-853 is a selective covalent KRAS(G12C) inhibitor that inhibits mutant KRAS-driven signaling by binding to the GDP-bound oncoprotein and preventing activation ARS-853 also induces apoptosis
TARGETMOL CHEMICALS INC ARS-1323 5MG
Also available in 1mg 10mg 25mg 50mg 100mg 500mg and bulk. Please contact Fisher for quotes. ARS-1323 is the racemate of ARS-1620 and a mutant K-ras G12C inhibitor. purity: 98%
Selleck Chemical LLC ARS-853
ARS-853 is a selective covalent KRAS(G12C) inhibitor that inhibits mutant KRAS-driven signaling by binding to the GDP-bound oncoprotein and preventing activation ARS-853 also induces apoptosis
TARGETMOL CHEMICALS INC ARS-1630 5MG
Also available in 1mg 10mg 25mg 50mg 100mg and bulk. Please contact Fisher for quotes. ARS-1630 is a mutant K-ras G12C inhibitor. It is a less active enantiomer of ARS-1620. purity: 97%
Medchemexpress LLC ARS-853 | 1629268-00-3 | 98.4% | 432.94 | 100 MG
ARS-853 is a cell-active, selective, covalent KRAS G12C inhibitor that targets mutant KRAS-driven signaling. It works by binding to the GDP-bound oncoprotein, thereby preventing its activation.
- Cell-active, selective, covalent KRAS G12C inhibitor
- Inhibits mutant KRAS-driven signaling
- Binds to GDP-bound oncoprotein
- Prevents KRAS activation
- IC50 of 2.5 μM
- Molecular weight of 432.94
- Purity of 98.4%
- Appearance as a solid
- Color is white to off-white
Medchemexpress LLC ARS-1323 | 1698024-73-5 | 430.84 | 10 MG
ARS-1323 is a KRAS G12C inhibitor that specifically binds to the cysteine residue on the mutant K-Ras protein, locking it in the GDP-bound conformation. This action blocks K-Ras activation and downstream signaling pathways. It can be used to investigate signal transduction mechanisms and growth characteristics of tumor cells driven by K-Ras G12C.
- Targets Ras
- Inhibits GPCR/G Protein and MAPK/ERK pathway
- Powder storage: -20°C for 3 years, 4°C for 2 years
- In solvent storage: -80°C for 2 years, -20°C for 1 year
- Solubility in DMSO: 100 mg/mL (232.10 mM)
- In vivo solubility options available
Medchemexpress LLC ARS-1630 | 1698055-86-5 | 430.84 | 25 MG
ARS-1630 is a novel inhibitor of mutant K-ras G12C, derived from patent WO 2015054572 A1. It is characterized as a less active enantiomer of ARS-1620. This compound targets mutant K-ras G12C, which is considered potentially druggable through allele-specific covalent targeting of Cys-12 near an inducible allosteric switch II pocket. This approach relies on the active cycling of KRAS G12C between its active-GTP and inactive-GDP conformations, as the accessibility of the switch II pocket is limited to the GDP-bound state.
- Specifically inhibits mutant K-ras G12C.
- It is a less active enantiomer of ARS-1620.
- Molecular weight: 430.84.
- Chemical formula: C21H17ClF2N4O2.
- Appears as a white to yellow solid.
Medchemexpress LLC ARS-1323 | 1698024-73-5 | 430.84 | 1 ML
ARS-1323 is a KRAS G12C inhibitor that specifically binds to the cysteine residue on the mutant K-Ras protein. This action locks K-Ras in its GDP-bound conformation, effectively blocking its activation and subsequent downstream signaling pathways. It is utilized for investigating signal transduction mechanisms and the growth characteristics of tumor cells driven by K-Ras G12C.
- Specifically binds to the cysteine residue on mutant K-Ras protein
- Blocks K-Ras activation and downstream signaling pathways
- Used to investigate signal transduction mechanisms
- Used for studying growth characteristics of KRAS G12C-driven tumor cells
- High purity of 99.7%
- Available in solid and solution formulations
Medchemexpress LLC Ars-1630 | 1698055-86-5 | 430.84 | 100 MG
ARS-1630 is a novel inhibitor of mutant K-ras G12C, whose properties are derived from patent WO 2015054572 A1. It is a less active enantiomer of ARS-1620 and is supplied as a white to yellow solid.
- Inhibits mutant K-ras G12C
- Less active enantiomer of ARS-1620
- Available in solid form
- White to yellow appearance
Med Vet International Jorvet Left/Right Thumb Grip, for 10cc Hauptner Syringe, J0031D02A
Jorvet Left/Right Thumb Grip, for 10cc Hauptner Syringe.
Med Vet International Jorvet O-Ring for 10cc Syringe, J0111ANO
NY, CT, IL, NJ, NH, DE and MN restrict the sale of syringes and needles to licensed professionals and entities. By proceeding to purchase through our website, you acknowledge that you are over 18 years of age.
Med Vet International Dial Flowmeter w/Female DISS & Male DISS, J0534EFM
Wall style Quick release female DISS flowmeter, can hook right to male DISS i.e. ‘H’ tank regulator. Dial flowmeter 1-15 LPM. Outlet end is a male DISS fitting.
Med Vet International Jorvet Plunger Plate for 10cc Hauptner Syringe, J0031D12A
Replacement plunger plate for Jorvet 10cc Hauptner syringe.