Hydroxybenzoic Acid Derivatives
4-Fluorobenzoyl Chloride 97.0+%, TCI America™
CAS: 403-43-0 Molecular Formula: C7H4ClFO Molecular Weight (g/mol): 158.556 MDL Number: MFCD00000684 InChI Key: CZKLEJHVLCMVQR-UHFFFAOYSA-N Synonym: benzoyl chloride, 4-fluoro,p-fluorobenzoyl chloride,benzoyl chloride, p-fluoro,p-fluorobenzoic acid chloride,4-fluorobenzoylchloride,fluorobenzoyl 4-chloride,4-fluorobenzoic acid chloride,p-fluorobenzoylchloride,p-fluorobenzoyl choride,4-flurobenzoyl chloride PubChem CID: 67879 IUPAC Name: 4-fluorobenzoyl chloride SMILES: C1=CC(=CC=C1C(=O)Cl)F
2,4,6-Trichlorobenzoic Acid 98.0+%, TCI America™
CAS: 50-43-1 Molecular Formula: C7H3Cl3O2 Molecular Weight (g/mol): 225.449 MDL Number: MFCD00060699 InChI Key: RAFFVQBMVYYTQS-UHFFFAOYSA-N Synonym: benzoic acid, 2,4,6-trichloro,unii-0bwg1hx6ck,2,4,6-trichlorobenzoicacid,2,4,6-trichloro-benzoic acid,0bwg1hx6ck,2,4,6-trichlorbenzoes,pubchem18496,acmc-209kme,2,4,6-trichlorobbenzoicacid,ksc270e7f PubChem CID: 5764 IUPAC Name: 2,4,6-trichlorobenzoic acid SMILES: C1=C(C=C(C(=C1Cl)C(=O)O)Cl)Cl
Methyl 3-Bromo-4-methylbenzoate 98.0+%, TCI America™
CAS: 104901-43-1 Molecular Formula: C9H9BrO2 Molecular Weight (g/mol): 229.073 MDL Number: MFCD00144769 InChI Key: MASRAGFWFYHMFI-UHFFFAOYSA-N Synonym: 3-bromo-4-methylbenzoic acid methyl ester,methyl 3-bromo-p-toluate,methyl3-bromo-4-methylbenzoate,benzoic acid, 3-bromo-4-methyl-, methyl ester,3-bromo-p-toluic acid methyl ester,3-bromo-4-methyl methyl benzoate,3-bromo-4-methyl-benzoic acid methyl ester,pubchem3967,acmc-2098dw,methyl 3-bromo4-methylbenzoate PubChem CID: 7015747 IUPAC Name: methyl 3-bromo-4-methylbenzoate SMILES: CC1=C(C=C(C=C1)C(=O)OC)Br
Medchemexpress LLC 4-Hydroxymethylpyrazole | 25222-43-9 | 99.74% | 98.11 | 25 G
4-Hydroxymethylpyrazole is the primary metabolite of Fomepizole, resulting from hepatic oxidative metabolism. Its plasma concentration correlates positively with the administered Fomepizole dosage, and it has a relatively short half-life. It inhibits alcohol dehydrogenase (ADH) in humans and monkeys, although its in vivo impact is considered negligible due to a significantly higher inhibition constant than Fomepizole.
- Functions as an endogenous metabolite
- Demonstrates inhibitory effects on alcohol dehydrogenase
- Suitable for research in metabolic diseases and natural products
Medchemexpress LLC 4-hydroxymethylpyrazole | 25222-43-9 | 99.7% | 98.11 | 10 G
4-Hydroxymethylpyrazole is the primary metabolite of Fomepizole produced through hepatic oxidative metabolism. It exhibits a plasma concentration positively correlated with the administered dosage of Fomepizole and has a relatively short half-life. It also demonstrates inhibitory effects on alcohol dehydrogenase (ADH) in both humans and monkeys, though its inhibition constant is significantly higher than Fomepizole, making its in vivo impact negligible.
- Primary metabolite of Fomepizole
- Exhibits plasma concentration positively correlated with Fomepizole dosage
- Relatively short half-life
- Demonstrates inhibitory effects on alcohol dehydrogenase (ADH)
- For research use only
Medchemexpress LLC 4-Hydroxymethylpyrazole | 25222-43-9 | 99.7% | 98.11 | 100 G
4-Hydroxymethylpyrazole is the primary metabolite of Fomepizole, produced through hepatic oxidative metabolism. It exhibits a plasma concentration positively correlated with the administered dosage of Fomepizole and has a relatively short half-life. This compound demonstrates inhibitory effects on alcohol dehydrogenase (ADH) in humans and monkeys, though its in vivo impact is negligible due to a significantly higher inhibition constant compared to Fomepizole. It is intended for research use only.
- Primary metabolite of Fomepizole
- Produced through hepatic oxidative metabolism
- Exhibits plasma concentration positively correlated with administered dosage
- Relatively short half-life
- Demonstrates inhibitory effects on alcohol dehydrogenase (ADH)
- For research use only
Medchemexpress LLC 4-Hydroxymethylpyrazole | 25222-43-9 | 99.7% | 98.11 | 5 G
4-Hydroxymethylpyrazole is the primary metabolite of Fomepizole, produced through hepatic oxidative metabolism. It has a plasma concentration positively correlated with the administered dosage of Fomepizole and a relatively short half-life. It inhibits alcohol dehydrogenase (ADH) in humans and monkeys, but its inhibition constant is significantly higher than Fomepizole's, rendering its in vivo impact negligible.
- Primary metabolite of Fomepizole
- Produced through hepatic oxidative metabolism
- Plasma concentration positively correlated with administered dosage
- Relatively short half-life
- Inhibits alcohol dehydrogenase (ADH) in humans and monkeys
- In vivo impact negligible
Medchemexpress LLC KH-4-43 | 2813310-07-3 | 99.7% | 422.74 | 1 ML
KH-4-43 is an inhibitor of E3 CRL4, inhibiting its core ligase complex and demonstrating anticancer activity. It is suitable for research use only.
- Inhibits E3 CRL4 core ligase complex
- Demonstrates anticancer activity
- Binding Kd to E3 ROC1-CUL4A CTD is 83 nM
- Binding Kd to ROC1-CUL1 CTD is 9.4 μM
Medchemexpress LLC Bromo-PEG3-azide | 1446282-43-4 | 98.2% | C8H16BrN3O3 | 250 MG
Bromo-PEG3-azide is a PEG-based PROTAC linker used in the synthesis of PROTACs. It also serves as a click chemistry reagent with an Azide group, enabling copper-catalyzed azide-alkyne cycloaddition (CuAAc) with Alkyne-containing molecules. It can also participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
- PEG-based PROTAC linker
- Click chemistry reagent
- Contains an azide group
- Facilitates copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc)
- Engages in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions
- For research use only
Medchemexpress LLC 4-Hydroxymethylpyrazole | 25222-43-9 | MFCD06797673 | 99.7% | 98.11 | 50 G
4-Hydroxymethylpyrazole is the primary metabolite of Fomepizole (HY-B0876) and is produced through hepatic oxidative metabolism. It shows a plasma concentration that correlates with the administered dosage of Fomepizole and has a relatively short half-life. While it inhibits alcohol dehydrogenase (ADH) in humans and monkeys, its inhibition constant is significantly higher than that of Fomepizole, making its in vivo impact negligible.
- Primary metabolite of Fomepizole.
- Exhibits plasma concentration positively correlated with dosage.
- Demonstrates inhibitory effects on alcohol dehydrogenase (ADH) in both humans and monkeys.
- For research use only.
Medchemexpress LLC 4-Bromo-3-fluorobenzaldehyde | 133059-43-5 | 203.01 | 5 G
4-Bromo-3-fluorobenzaldehyde is a drug intermediate that can be used for the synthesis of triaryl dimer antibacterial compounds.
- For research use only.
- Not for sale to patients.
Medchemexpress LLC 4,7,10,13,16,19,22,25-octaoxaoctacosanedioic acid | 1246189-43-4 | 98.0% | 470.51 | C20H38O12 | 250 MG
Bis-PEG8-acid is a polyethylene glycol (PEG) based bifunctional linker with terminal carboxylic acid groups used for PROTAC synthesis and as a cleavable linker in antibody-drug conjugates (ADCs).
- Provides a flexible PEG8 spacer for conjugation chemistry
- Contains terminal carboxylic acid groups for amide coupling
- Molecular formula C20H38O12 and molecular weight 470.51
- Purity 98.0%
- Available in multiple package sizes, including 250 MG
- Powder storage: -20°C (stable 3 years) or 4°C (stable 2 years)
- In solvent storage: -80°C (stable 6 months) or -20°C (stable 1 month)
Medchemexpress LLC 4,7,10,13,16,19,22,25-octaoxaoctacosanedioic acid | 1246189-43-4 | 98.0% | 470.51 | C20H38O12 | 10 G
Bis-PEG8-acid is a bifunctional polyethylene glycol (PEG) linker with two terminal carboxylic acid groups used for the synthesis of PROTACs and antibody-drug conjugates. It is a white to light yellow solid with high purity and good solubility in DMSO.
- Contains two terminal carboxylic acid groups.
- Molecular formula C20H38O12; molecular weight 470.51.
- Purity 98.0%.
- Soluble in DMSO at 100 mg/mL (≈212.54 mM).
- Storage: powder at -20°C for long term; in solvent store at -80°C for up to 6 months.
- Available in multiple pack sizes including 10 g.
Medchemexpress LLC 4,7,10,13,16,19,22,25-octaoxaoctacosanedioic acid | 1246189-43-4 | >98.0% | 470.51 g·mol⁻¹ | C20H38O12 | 100 MG
Bis-PEG8-acid is a polyethylene glycol (PEG)-based bifunctional linker used for conjugation chemistry in the synthesis of PROTACs and cleavable antibody-drug conjugates. It provides a PEG8 spacer with terminal carboxylic acid groups to enable standard coupling reactions and is supplied for research use.
- PEG8 spacer with terminal carboxylic acid groups.
- Suitable for PROTAC linker synthesis and cleavable ADCs.
- High purity; >98.0% reported by manufacturer.
- Available in multiple pack sizes for research workflows.
Medchemexpress LLC 4,7,10,13,16,19,22,25-octaoxaoctacosanedioic acid | 1246189-43-4 | >97.0% | 470.51 g/mol | C20H38O12 | 500 MG
Bis-PEG8-acid is a polyethylene glycol (PEG)-based cleavable linker containing terminal carboxylic acid groups. It is used as a hydrophilic spacer in the synthesis of proteolysis targeting chimeras (PROTACs) and antibody-drug conjugates (ADCs), improving solubility and flexibility between conjugated moieties.
- Cleavable PEG-based linker with terminal carboxylic acids.
- Hydrophilic spacer that increases aqueous solubility.
- Facilitates conjugation in PROTAC and ADC synthesis.
- High purity suitable for research applications.
- Supplied as a 500 mg quantity for laboratory use.
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