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Filtered Search Results
Medchemexpress LLC JH-X-119-01 hydrochloride | 2591344-30-6 | 99.1% | 488.93 g/mol | C25H21ClN6O3 | 50 MG
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JH-X-119-01 hydrochloride is a research-grade small-molecule inhibitor of interleukin-1 receptor-associated kinase 1 (IRAK1). It is supplied as a solid with high reported purity and has demonstrated activity in preclinical LPS-induced sepsis models. Intended for laboratory research use only.
- Potent, selective IRAK1 inhibitor.
- Demonstrated efficacy in LPS-induced sepsis mouse models.
- High purity suitable for research applications.
- Solid form, light yellow to yellow in color.
- Provided in small milligram packaging for preclinical studies.
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000724230 AZITHROMYCIN IMPURIT 1MG
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Apexbio Technology LLC Lomeguatrib 192441-08-0 10mg
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Lomeguatrib (CAS 192441-08-0) is a potent inhibitor of O6-alkylguanine-DNA methyltransferase (MGMT) an enzyme involved in DNA repair that mitigates the cytotoxic effects of alkylating agents In MCF-7 cells Lomeguatrib inactivates MGMT with an approximate IC50 of 6 nM By suppressing MGMT activity Lomeguatrib sensitizes MGMT-expressing cell lines such as A375P and select mutBRAF and mutNRAS melanoma models to temozolomide but does not alter sensitivity to dacarbazine Clinical investigations have demonstrated dose-dependent inactivation of MGMT in patient-derived tumor tissues and peripheral blood mononuclear cells highlighting Lomeguatrib s value as a research tool for studying MGMT-mediated resistance mechanisms in cancer
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Selleck Chemical LLC Azathramycin S4978-25mg
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Azathramycin (Azaerythromycin A Azaerythromycin) is a macrolide antibiotic containing cladinose
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Apexbio Technology LLC Norfloxacin 70458-96-7 5g
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Norfloxacin (70458-96-7) is a small-molecule inhibitor targeting bacterial DNA gyrase It is designed to inhibit DNA gyrase thereby interfering with bacterial DNA replication and transcription Norfloxacin exerts its biological activity primarily through inhibition of topoisomerase activity by binding to bacterial DNA gyrase disrupting DNA supercoiling and strand separation Norfloxacin demonstrates broad-spectrum antibacterial inhibition with reported IC50 values ranging from approximately 0 1 to 10 M depending on bacterial species and assay conditions Based on these pharmacological properties norfloxacin holds research potential in studies of bacterial DNA replication mechanisms antimicrobial susceptibility assays and resistance analyses
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Selleck Chemical LLC Erythromycin S1635-1g
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Erythromycin (E-Mycin) is a macrolide antibiotic that has an antimicrobial spectrum similar to or slightly wider than that of penicillin (IC50 1 5 g/ml)
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Medchemexpress LLC Tiotropium Bromide | 136310-93-5 | 99.9% | 472.42 | 500 MG
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Tiotropium Bromide is a potent muscarinic acetylcholine receptor (mAChR) antagonist. It works by blocking the binding of acetylcholine, which prevents the opening of ligand-gated ion channels. This action leads to the cessation of neuronal signaling and muscle relaxation. As a long-acting, 24-hour anticholinergic bronchodilator, it is widely used in the management of chronic obstructive pulmonary disease and can also alleviate symptoms in cases complicated by chronic heart failure.
- mAChR antagonist
- Blocks acetylcholine binding
- Leads to muscle relaxation
- 24-hour anticholinergic bronchodilator
- Manages chronic obstructive pulmonary disease
- Improves symptoms in chronic heart failure complications
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Medchemexpress LLC Posaconazole-d4 | 1133712-26-1 | 99.9% | 704.80 | 1 MG
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Posaconazole-d4 is a deuterium-labeled form of Posaconazole, a broad-spectrum, second-generation triazole compound with antifungal activity. This compound is suitable for various laboratory applications.
- Used as a tracer
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
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Apexbio Technology LLC Cefadroxil (hydrate),250mg CAS# 66592-87-8
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Cefadroxil is a new semisynthetic cephalosporin with a broad antibacterial spectrum and a high chemotherapeutic potential [1]. In vitro: The inhibitory activity of this compound was similar to that of cephalexin and cephradine when tested against 602 clinical isolates on Mueller-Hinton medium. In the oral treatment of experimental infections of mice, cefadroxil was more effective than cephalexin against Streptococcus pyogenes, and comparably effective against Streptococcus pneumoniae, Staphylococcus aureus, and several gram-negative species [1].In vivo: In mice, oral administration of cefadroxil at doses ranging from 25 to 100 mg/kg attained peak concentrations in the blood. Higher peak levels were noted with cefadroxil than with cephalexin at a dose of 200 mg/kg [1].Other sizes are also available. Please inqury us for quote.
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Apexbio Technology LLC SJB2-043 63388-44-3 5mg
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SJB2-043 (CAS 63388-44-3) is a small molecule inhibitor of ubiquitin-specific protease 1 (USP1) a deubiquitinating enzyme involved in the regulation of DNA repair by deubiquitinating key proteins in the Fanconi anemia (FA) pathway SJB2-043 exhibits an IC50 of 0 544 M for USP1 In cellular models such as K562 leukemia cells and primary AML cells SJB2-043 reduces USP1 levels and promotes proteasomal degradation of ID1 as well as decreasing ID2 and ID3 protein levels Treatment with SJB2-043 also increases Ub-FANCD2 and Ub-PCNA in HeLa cells reflecting modulation of DNA repair processes This compound serves as a valuable tool for studies investigating USP1 function and the regulation of ID proteins in cancer and stem cell biology
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Sigma Aldrich Fine Chemicals Biosciences Diphenhydramine hydrochloride British Pharmacopoeia (BP) Reference Standard | 147-24-0 | MFCD00012479 |
Diphenhydramine hydrochloride British Pharmacopoeia (BP) Reference Standard | Mol Wt: 291.82 | 147-24-0 | MFCD00012479 |
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Apexbio Technology LLC Enoxacin (Penetrex) 74011-58-8 50mg
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Enoxacin (Penetrex) (CAS 74011-58-8) is a small-molecule inhibitor targeting bacterial DNA gyrase and topoisomerase IV It is designed to interfere with bacterial DNA replication and transcription by inhibiting these essential enzymes thereby disrupting cellular DNA processes Enoxacin exerts its biological activity primarily through stabilization of enzyme-DNA cleavage complexes leading to inhibition of DNA replication In in vitro studies enoxacin demonstrates inhibitory activity with reported IC50 values against bacterial DNA gyrase typically ranging between 0 5 10 g/mL depending on bacterial species and assay conditions Based on these pharmacological properties enoxacin holds research potential in studies of DNA topology bacterial resistance mechanisms and antimicrobial pharmacodynamics
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Apexbio Technology LLC SANT-1 304909-07-7 10mg
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SANT-1 (CAS 304909-07-7) is a small molecule antagonist targeting the Smoothened (Smo) transmembrane protein a central component of the Hedgehog (Hh) signaling pathway Dysregulation of Smo activity is implicated in aberrant cell differentiation and proliferation contributing to oncogenesis High-throughput assays indicate that SANT-1 exhibits potent inhibition of Smo with IC50 values of 20 nM and 30 nM in Shh-LIGHT2 and SmoA1-LIGHT2 cell models respectively and demonstrates high binding affinity (KD 1 2 nM) In pancreatic cancer cell lines SANT-1 suppresses Panc-1 cell growth with an IC50 of 100 M Additionally co-administration with SAHA enhances anti-tumor effects via synergistic inhibition of Hh signaling SANT-1 serves as a valuable research tool for studying Hh pathway modulation and investigating combination therapeutic strategies in cancer models
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MEDCHEMEXPRESS LLC TES-991 5MG
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501872404 TES-991 5MG
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MEDCHEMEXPRESS LLC PALMITODIOLEIN 10MG
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501872359 PALMITODIOLEIN 10MG
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