Use fibroblast growth factor 8B (FGF-8B) to activate PI3K and MAPK pathways. FGF-8B has broad mitogenic and cell survival activities, and regulates gastrulation, epithelial-mesenchymal transition, and later on mesenchymal to epithelial differentiation during embryonic development (Klagsbrun. Prog Growth Factor Res, 1989). FGF-8B has mitogenic effects on somatic cells in the germinal epithelium and is expressed in adult mouse ovarian cells and tissues. This suggests that it regulates maturation of oocytes and seminiferous epithelium in testis (Valve et al. Biochem Biophys Res Commun, 1997). Human recombinant FGF-8B from STEMCELL comes lyophilized with ≥ 95% purity; specific activity EC50 ≤ 5 ng/mL; endotoxin levels verified ≤ 0.2 EU/μg protein. Alternative names: AIGF, Androgen-induced growth factor, FGF-8, FGF-8B, Fibroblast growth factor-8B, HBGF-8, Heparin-binding growth factor 8; HH6, KAL6. Visit STEMCELL.com for more information.