General Cell Lines and Cell Cultures
Eurofins Discoverx ChemiScreen SST5 Somatostatin Receptor Stable Cell Line, 2 vials. (HTS139C)
The ChemiScreen SST5 Somatostatin Receptor Stable Cell Line is an engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. somatostatin) based activation of SSTR5 GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses SSTR5 alongside endogenous high levels of the promiscuous G protein, Gα15, coupling the receptor to the calcium signaling pathway. Upon activation of SSTR5, the resulting calcium activity can be fluorescently assayed. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, visit www.discoverx.com/targets/gpcr-target-biology.
Amsbio LLC SW480 Wnt reporter stable cell Line (Active)
SW480 Wnt reporter stable cell Line (Active)
ATCC P3X63Ag8.653; Plasmacytoma; Mouse (Mus musculus)
P3X63Ag8.653 is a B lymphoblast cell line that was isolated from a mouse with plasmacytoma. This cell line was deposited by JF Kearney and can be used in immunology and immune system disorder research.
Eurofins Discoverx PathHunter U2OS mRHO(P23H) MEM-EA Pharmacotrafficking Assay, 2 vials. (93-1077C3)
The PathHunter U2OS mRHO(P23H) MEM-EA Pharmacotrafficking Assay is a stable, engineered cell line for use in studying pharmacochaperones targeting mRHO. This cell line enables assessment of chaperone-based stabilization of mRHO(P23H) via detection of rescued membrane trafficking. The included cell line overexpresses ProLink-tagged mutant mRHO(P23H), which is misfolded and retained in the ER. The cell line also expresses membrane-localized EA. When a pharmacochaperone stabilizes the mutant mRHO, it is trafficked to the membrane, producing EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
ATCC Fibroblast Growth Kit-Serum-free
Fibroblast Growth Kit–Serum-free (ATCC PCS-201-040) and Fibroblast Growth Kit–Low Serum (ATCC PCS-201-041) each contain components that when added to Fibroblast Basal Medium (ATCC PCS-201-030) creates a complete ATCC Primary Cell Solutions culture environment for fibroblasts (eg, Dermal Fibroblasts, Normal, Human Neonatal, ATCC PCS-201-010).
Eurofins Discoverx PathHunter U2OS BMPR1B/ACVR2B Dimerization Cell Line, 2 vials. (93-1052C3)
The PathHunter BMPR1B/ACVR2B Dimerization cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting receptor-receptor interaction. This cell line enables assessment of ligand (e.g. BMP-6) induced dimerization of BMPR1B/ACVR2B receptors. This product uses EFC technology. The cell line included overexpresses ACVR2B target protein fused to PK alongside BMPR1B target protein fused to EA. Upon ligand-induced dimerization of BMPR1B/ACVR2B, detectable EFC signal is produced. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/kinases.
Biochain Institute Inc Paraffin Tissue Section - Human Bone Tumor, 5 sides/PK
BioChain's tissue products are based on the sample repository network established following the IRB-approved ethical standard and procedures. BioChain's formalin fixed paraffin embedded (FFPE) tissue section line encompasses a large selection of tissue sections which are suitable for immunohistochemistry and in situ hybridization assays. The tissue sections are approximately 5 um thick. Each slide contains tissue from a single human tumor. Documentation of tissues' clinical histories may be available upon request. For those customers who want to perform FFPE DNA and RNA isolation, BioChain can provide tissue section slices in tubes instead of mounting them on glass slides.
ATCC LNCaP clone FGC; Prostate Carcinoma; Human (Homo sapiens)
LNCaP clone FGC is a cell line exhibiting epithelial morphology that was isolated in 1977 by J.S. Horoszewicz, et al., from a needle aspiration biopsy of the left supraclavicular lymph node of a 50-year-old, White, male (blood type B+) with confirmed diagnosis of metastatic prostate carcinoma. This cell line can be used in cancer research.
ATCC Streptococcus pneumoniae; 262
Streptococcus pneumoniae strain 262 is a whole-genome sequenced bacterium that was isolated in Arizona from the sputum of a 75-year-old human male. This bacterial culture has applications in susceptibility disc testing and respiratory disease research. This strain is serotype 19 (Danish designation 19F).
Eurofins Discoverx PathHunter U2OS KCNH2(G601S) MEM-EA Pharmacotrafficking Assay, 2 vials. (93-1064C3)
The PathHunter U2OS KCNH2(G601S) MEM-EA Pharmacotrafficking Assay is a stable, engineered cell line for use in studying pharmacochaperones targeting KCNH2. This cell line enables assessment of chaperone-based stabilization of KCNH2(G601S) via detection of rescued membrane trafficking. The included cell line overexpresses ProLink-tagged mutant KCNH2(G601S), which is misfolded and retained in the ER. The cell line also expresses membrane-localized EA. When a pharmacochaperone stabilizes the mutant KCNH2, it is trafficked to the membrane, producing EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
ATCC Bartonella henselae
Bartonella henselae strain Houston-1 [CIP 103737, G5436] was isolated in Houston, Texas, from the blood of an HIV-positive male. This whole-genome sequenced bacterial type strain has applications in infectious disease research and vector-borne disease research.
Biochain Institute Inc Paraffin Tissue Section - Parkinson's Disease: Brain: Occipital Lobe, 5 slides/PK
BioChain's tissue products are based on the sample repository network established following the IRB-approved ethical standard and procedures. BioChain's formalin fixed paraffin embedded (FFPE) tissue section line encompasses a large selection of tissue sections which are suitable for immunohistochemistry and in situ hybridization assays. The tissue sections are approximately 5 um thick. Each slide contains tissue from single human diseased sample. Documentation of tissues' clinical histories may be available upon request. For those customers who want to perform FFPE DNA and RNA isolation, BioChain can provide tissue section slices in tubes instead of mounting them on glass slides.
Biochain Institute Inc Lung Tumor and Normal Tissue Array 60 spots: Duplicated spots from lung tumor tissues (25 donors) and lung normal tiss, 2 slides/PK
BioChain's tissue arrays or tissue microarrays (TMAs) are a useful tool in biomarker research and drug target validation. It consists of paraffin blocks that are assembled in array fashion to allow multiplex histological analysis. BioChain's TMAs provide a valuable tool for analysis of protein, RNA, or DNA molecules in oncology, both the malignant and metastatic markers. TMAs can also be constructed with tissues from other diseases and species.
Biochain Institute Inc Matched Pair - Paraffin Tissue Section - Human Primary and Matched Metastatic Tumor (PM): Kidney, 5 x2 slides /PK
BioChain's human paraffin tissue section (FFPE) matched pair products include: Primary Pair (PP), Primary and Metastatic Pair (PM). ??PP consists of paraffin tissue sections of primary tumor and its adjacent normal tissue; PM consists of paraffin tissue sections of primary tumor and corresponding metastatic tumor. Paraffin tissue sections in each pair are prepared from the same donor. This product line is ideal for localization of tumor- specific genes and tumor metastatic genes.
ATCC HCC1937; Breast Carcinoma; Human (Homo sapiens)
HCC1937 were isolated from a primary ductal carcinoma derived from a 23-year-old, White female with stage IIB breast cancer. This cell line was initiated in 1995 and took 11.5 months to establish.