General Cell Lines and Cell Cultures
Thermo Scientific™ GeneBLAzer™ Gqi5-NFAT-bla CHO-K1 Cells
The GeneBLAzer™ Gqi5-NFAT-bla CHO-K1 cell line contains the promiscuous Gα protein, Gqi5, stably integrated into the CellSensor™ NFAT-bla CHO-K1 cell line.
Thermo Scientific™ GeneBLAzer™ ERα-UAS-bla GripTite™ Cells
ER alpha-UAS-bla GripTite™cells contain the ligand-binding domain (LBD) of the human Estrogen receptor alpha (ER alpha) fused to the DNA-binding domain of GAL4 stably integrated in the GeneBLAzer™ UAS-bla GripTite™ cell line.
Thermo Scientific™ CellSensor™ irf1-bla TF-1 Cell Line
Jak/Stat signaling pathways play essential roles in cellular responses to distinct cytokines. One of the Jak/Stat pathways, Jak2/Stat5, mediates cell proliferation in response to Interleukin-3 (IL-3), prolactin, erythropoietin (Epo), and granulocyte-macrophage colony stimulating factor (GM-CSF).
Thermo Scientific™ CellSensor™ SIE-bla THP-1 Cell Line
The CellSensor™ SIE-bla THP-1 cell line contains a beta-lactamase reporter gene under control of the Sis Inducible Element (SIE), stably integrated into THP-1 cells.
Thermo Scientific™ CellSensor™ c-Fos-bla ME-180 Cell Line
The CellSensor™ c-fos-bla ME-180 cell line contains a beta-lactamase reporter gene under control of the c-fos response element stably integrated into ME-180 cells.
Thermo Scientific™ CellSensor™ AP-1-bla A375 Cell Line
The CellSensor™ AP1-bla A375 cell line contains a beta-lactamase reporter gene under control of the AP1 response element stably integrated into A375 cells.
Thermo Scientific™ CellSensor™ irf1-bla CTLL-2 Cell Line
Jak/Stat signaling pathways play essential roles in the cellular responses to distinct cytokines.
Thermo Scientific™ LanthaScreen™ STAT3 GripTite™ Cell Line
The JAK/STAT3 signaling pathway is known to be activated by cytokines such as IL-6. In this pathway, binding of IL-6 to its cell-surface receptors results in the activation of JAKs, which in turn phosphoactivate STAT3 proteins at a specific tyrosine residue (Y705).
Thermo Scientific™ GeneBLAzer™ ADRA1A-NFAT-bla CHO-K1 Cells
The GeneBLAzer™ ADRA1A-NFAT-bla CHO-K1 cells contain the human Adrenergic Alpha-1A Receptor (ADRA1A), (Accession No. NM_000680) stably integrated into the CellSensor™ NFAT-bla CHO-K1 cell line.
Thermo Scientific™ GeneBLAzer™ NPSR1-B-NFAT-bla CHO-K1 Cells
The GeneBLAzer™ NPSR1-B-NFAT-bla CHO-K1 cells contain the human Neuropeptide S Receptor 1-Isoform B (NPSR1-B), (Accession # NP_997056) stably integrated into the CellSensor™ NFAT-bla CHO-K1 cell line.
Thermo Scientific™ GeneBLAzer™ ADORA2A-CRE-bla CHO-K1 Cells
GeneBLAzer™ ADORA2A-CRE-bla CHO-K1 cells contain the human Adenosine Receptor A2A (ADORA2A) stably integrated into the CellSensor™ CRE-bla CHO-K1 cell line.
Thermo Scientific™ Tango™ EDG8-bla U2OS Cells
The Tango™ EDG8-bla U2OS cells contain the human Endothelial Differentiation Gene 8 (EDG8) linked to a TEV protease site and a Gal4-VP16 transcription factor stably integrated into the Tango™ GPCR-bla U2OS parental cell line.
Thermo Scientific™ Tango™ NPY2R-bla U2OS Cells
The Tango™ NPY2R-bla U2OS cells contain the human Neuropeptide Y Receptor Y2 (NPY2R) linked to a TEV protease site and a Gal4-VP16 transcription factor stably integrated into the Tango™ GPCR-bla U2OS parental cell line.
Thermo Scientific™ CellSensor™ DHFR/E2F-bla NIH3T3 Cell Line
The CellSensor™ dhfr(E2F)-bla NIH 3T3 Cell Line contains a beta-lactamase reporter gene under control of the E2F/DP1 binding sequence from the DHFR gene promoter, stably integrated into NIH 3T3 cells.
Thermo Scientific™ GeneBLAzer™ ERRα-UAS-bla HEK 293T Cells
ERR alpha-UAS-bla HEK 293T cells contain the ligand-binding domain (LBD) of the human Estrogen related receptor alpha (ERR alpha) fused to the DNA-binding domain of GAL4 stably integrated in the GeneBLAzer UAS-bla HEK 293T cell line.