General Cell Lines and Cell Cultures
Genscript Corporation CHO-K1/MC5/G15 Stable Cell Li
The melanocortin receptor 5 MC5 receptor is Gs-coupled GPCRs expressed in the adrenal gland fat cells kidney leukocytes lung lymph node mammary gland ovary pituitary testis and uterus Mice with targeted deletion of the MC5 receptor have a defect in water and thermoregulation secondary to their decreased production of sebaceous lipids
ATCC Treponema medium
Treponema medium strain G7201 is a bacterial type strain that was isolated in 1972 from the subgingival plaque of an adult male with periodontitis.
ATCC Merck Pneumococcal polysaccharide powder Type 9 (d9N) 2mg
Purified pneumococcal polysaccharides are manufactured by Merck & Company for small quantity distribution by ATCC. The pneumococcal powders include those types which are components of the current 23-valent vaccine against Streptococcus pneumoniae.Each of the polysaccharide antigens used in the polyvalent vaccine is extracted and purified separately. These vaccine products can be used to assay for type-specific antibodies, research immune responses and study immunodeficiencies.
Eurofins Discoverx PathHunter CHO-K1 mP2RY12 β-Arrestin Cell Line, 2 vials. (93-0613C2)
The PathHunter mP2RY12 cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. ATP) based activation of mP2RY12 GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged mP2RY12 and EA-tagged β-Arrestin-2. Activation of mP2RY12 stimulates the recruitment of β-Arrestin-2 and produces EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. Please note that this product expresses the Mouse version of this protein. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
Eurofins Discoverx PathHunter U2OS TORC2 Nuclear Translocation Cell Line, 2 vials. (93-0813C3)
The PathHunter U2OS TORC2 Nuclear Translocation Cell Line is a stable, engineered cell line for use in studying drug candidates affecting the CRTC/CREB pathway. This cell line enables assessment of ligand (e.g. forskolin) based pathway activation via detection of resulting TORC2 (CRTC2) nuclear translocation. This product uses EFC technology. The included cell line overexpresses ProLabel-tagged TORC2 (CRTC2) and nuclear localized EA. Upon pathway activation, induced nuclear translocation of TORC2 leads to production of EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/pathways.
Biochain Institute Inc Matched Pair - Total Protein - Human Primary Tumor and Metastatic Tumor Tissue (PM): Liver, 0.2 x2 mg /PK
BioChain's human total protein matched pair products include: Primary Pair (PP), Primary and Metastatic Pair (PM). PP consists of total protein isolated from primary tumor and its adjacent normal tissue; PM consists of total protein from primary tumor andcorresponding metastastic tumor. Total proteins in each pair are prepared from the same donor. This product line is designedfor identifying tumor-specific genes and tumor metastasis genes.
ATCC Respiratory Exclusivity Panel
This panel of seven quantitative genomic and synthetic nucleic acid preparations was selected from respiratory pathogen strains commonly cited in exclusivity or cross-reactivity studies in SARS-CoV-2 EUA submissions and/or FDA 510(k) submissions.
ATCC NCI-H889; Lung Carcinoma; Human (Homo sapiens)
NCI-H889 [H889] is a cell line exhibiting epithelial morphology that was isolated from the lungs of a 69-year-old, White female with carcinoma. This product has applications for cancer research.
Biochain Institute Inc Matched Pair - DNA - Human Primary and Metastatic Tumor Tissue: Kidney, 2x10 ug/PK
BioChain's human DNA matched pair products include: Primary Pair (PP), Primary and Metastasis Pair (PM). PP consists of DNA prepared from primary tumor and its adjacent normal tissue; PM consists of DNA prepared from primary tumor and corresponding ponding metastatic tumor. Genomic DNA in each pair is prepared from the same donor. This product line is designed foridentifying tumor-specific genes and tumor metastatic genes.
Medchemexpress LLC GIP Human HEK293 1mg
The GIP protein is a member of the glucagon superfamily an important incretin hormone that stimulates pancreatic beta cells to secrete insulin in response to food intake Through its G protein-coupled receptor it activates adenylyl cyclase and other signal transduction pathways GIP Protein Human (HEK293 hFc) is the recombinant human-derived GIP protein expressed by HEK293 with C-hFc labeled tag
Eurofins Discoverx PathHunter CHO-K1 GLP1R β-Arrestin-1 Cell Line, 2 vials. (93-0914C2)
The PathHunter GLP1R (ARR1) cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. exendin-4) based activation of GLP1R GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged GLP1R and EA-tagged β-Arrestin-1. Activation of GLP1R stimulates the recruitment of β-Arrestin-1 and produces EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
Eurofins Discoverx PathHunter U2OS GHR-JAK1 Functional Assay, 2 vials. (93-0756C3)
The PathHunter GHR-JAK1 Functional assay cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting CTKs. This cell line enables assessment of GHR activation via detection of JAK1 mediated phosphorylation-induced SH2 domain protein recruitment. This product uses EFC technology. The included cell line overexpresses ProLink-tagged GHR cytokine receptor, an untagged CTK JAK1 and EA-tagged SH2 domain protein. Upon activation of the cytokine receptor, CTK-based receptor phosphorylation leads to SH2-EA recruitment and production of EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/kinases.
Eurofins Discoverx PathHunter PTHR2 Total GPCR Internalization U2OS Cell Line, 2 vials. (93-0763C3)
The PathHunter PTHR2 Total GPCR internalization cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) affecting GPCR activation and internalization. This cell line uses EFC technology to measure ligand-induced internalization of PTHR2 via detection of localization to the early endosome. The included cell line overexpresses ProLink-tagged PTHR2 and an EA-tagged early endosome protein. Upon ligand-induced receptor activation, resulting internalization of the PTHR2 receptor to the early endosome leads to production of EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
Genscript Corporation CHO-K1/BTLA Stable Cell Line
The B and T lymphocyte attenuator (BTLA) is an Ig super family protein with an intermediate type Ig fold in the ectodomain and an ITIM inhibitory signaling domain in the cytosol BTLA interacts with the herpesvirus entry mediator (HVEM TNFRSF14) a TNFR super family member Engagement of BTLA by HVEM induces tyrosine phosphorylation of the ITIM motifs in the cytoplasmic tail of BTLA allowing the recruitment of the phosphatases SHP-1 and SHP-2 which attenuate signaling