General Cell Lines and Cell Cultures
Abcam CGP 35348, GABAB antagonist, 10MG
MW 225.22 Da. Selective GABAB antagonist (IC50 = 34 μM). Brain penetrant *in vivo*. Also available in simple stock solutions (ab146707) - add 1 ml of water to get an exact, ready-to-use concentration.
The product is subject to the following: Abcam Restricted Use Statement
Eurofins Discoverx PathHunter CHO-K1 GPR162 β-Arrestin Orphan GPCR Cell Line, 2 vials. (93-0383C2A)
The PathHunter GPR162 cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand based activation of GPR162 GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged GPR162 and EA-tagged β-Arrestin-2. Activation of GPR162 stimulates the recruitment of β-Arrestin-2 and produces EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. This is an orphan receptor without a known ligand. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
Eurofins Discoverx PathHunter CHO-K1 CXCR2 (IL8RB) β-Arrestin Cell Line, 2 vials. (93-0202C2)
The PathHunter CXCR2 (IL8RB) cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. CXCL8/IL8) based activation of CXCR2 GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged CXCR2 and EA-tagged β-Arrestin-2. Activation of CXCR2 stimulates the recruitment of β-Arrestin-2 and produces EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
Revvity Health Sciences Inc AequoZen Human Adrenergic α1A Cell Line, CHO-K1 Frozen Cells
AequoZen Human Adrenergic α1A Cell Line, CHO-K1 Frozen Cells
Revvity Health Sciences Inc AequoZen Human GPR99 Cell Line, CHO-K1 Frozen Cells
AequoZen Human GPR99 Cell Line, CHO-K1 Frozen Cells
Medchemexpress LLC TPT-260 | 2154425-45-1 | >98% | C₃₀H₃₂FN₅O₅ | 100 MG
TPT-260 is a potent, selective, and orally active ATP-competitive PI3Kδ inhibitor. It potently inhibits PI3Kδ activity with a high degree of selectivity over other PI3K isoforms and kinases.
- Potent PI3Kδ inhibitor
- Selective inhibition over other PI3K isoforms and kinases
- Orally active
- ATP-competitive
Eurofins Discoverx PathHunter U2OS MCHR1 β-Arrestin-1 Cell Line, 2 vials. (93-0243C3)
The PathHunter MCHR1 (ARR1) cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. MCH) based activation of MCHR1 GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged MCHR1 and EA-tagged β-Arrestin-1. Activation of MCHR1 stimulates the recruitment of β-Arrestin-1 and produces EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
ATCC clone 1-5c-4; HeLa Contaminant; Human (Homo sapiens)
The clone 1-5c-4 [Wong-Kilbourne derivative (D) of Chang conjunctiva] cell line was originally thought to be derived from normal conjunctiva, but was subsequently found, based on isoenzyme analysis, HeLa marker chromosomes, and DNA fingerprinting, to have been established via HeLa cell contamination.
Genscript Corporation CHO-K1/TIGIT Stable Cell Line
TIGIT (T cell immunoreceptor with Ig and ITIM domains) was recently characterized as an inhibitory receptor which is expressed mainly on NK Treg CD8 T and CD4 T cells TIGIT harbors an immunoglobulin tail tyrosine (ITT)-like phosphorylation motif and an ITIM (immunoreceptor tyrosine-based inhibition motif) in its cytoplasmic tail The poliovirus receptor (PVR or CD155) was identified as the physical ligand of TIGIT with high affinity and PVRL2 (Nectin2 or CD112) also binds to TIGIT with a weaker binding capacity TIGIT/PVR engagement suppresses T cell activation through IL-10 secretion mediated by dendritic cells Furthermore TIGIT also exerts an intrinsic inhibitory function to T cell activation
Eurofins Discoverx PathHunter CHO-K1 GPR32 β-Arrestin Orphan GPCR Cell Line, 2 vials. (93-0321C2A)
The PathHunter GPR32 cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand based activation of GPR32 GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged GPR32 and EA-tagged β-Arrestin-2. Activation of GPR32 stimulates the recruitment of β-Arrestin-2 and produces EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. This is an orphan receptor without a known ligand. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
ATCC GK1.5; Hybridoma; Rat/Mouse (Rattus norvegicus/Mus musculus)
GK1.5 is a B lymphocyte cell that was isolated from the spleen of a mouse with leukemia. The antibody profoundly blocks antigen specific murine class II MHC antigen reactive helper T lymphocyte lines.
Eurofins Discoverx ChemiScreen BB3 Bombesin Receptor Membrane Preparation, 1 vial. (HTS160M)
The ChemiScreen BB3 Bombesin Receptor Membrane Preparation is derived from proprietary stable recombinant cells to ensure high levels of BRS3 surface expression. ChemiScreen membrane preps can be used to screen for ligand binding affinities using a competitive radio-labeled ligand approach. Increased binding affinities will lead to higher radioactive signal. Membrane preps contain 1 mL of 1 mg/mL frozen membranes derived from a stably modified clonal cell line which was chosen for optimal receptor expression. For detailed product information, visit www.discoverx.com/membranepreps.
ATCC CMT-93; Rectal Carcinoma; Mouse (Mus musculus)
CMT-93 is a cell line exhibiting epithelial morphology that was isolated from the rectum of a mouse with polyploid carcinoma. This cell line was deposited by LM Franks and can be used in cancer research.
ATCC Piezo1 knock-out HEK293T; Embryonic; Kidney; Human (Homo sapiens)
The Piezo1 knock-out HEK293T cell line can be used to assess ion channel activity by electrophysiology without any interference from endogenous mechanically activated currents caused by the ion channel Piezo1.
ATCC NCI-H1688; Lung Carcinoma; Human (Homo sapiens)
NCI-H1688 [H1688] is an epithelial-like cell that was derived from a liver metastasis isolated from the lung of a patient prior to therapy. This cell line can be used in cancer research.