General Cell Lines and Cell Cultures
Eurofins Discoverx PathHunter U2OS OPRM1 β-Arrestin Cell Line, 2 vials. (93-0213C3)
The PathHunter OPRM1 cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. met 5-enkephalin) based activation of OPRM1 GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged OPRM1 and EA-tagged β-Arrestin-2. Activation of OPRM1 stimulates the recruitment of β-Arrestin-2 and produces EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
Genscript Corporation CHO-K1/CB1/G15 Stable Cell Li
The cannabinoid receptor CNR1 is Gs-coupled GPCRs expressed in primarily CNS and some peripheral neurones particularly prevalent in basal ganglia hippocampus cerebellum cerebral cortex and also presented in some non-neuronal cells and tissues for example leukocytes and testis A shorter human splice variant (411aa) has been identified in the brain and other tissues by reverse-transcriptase PCR but mRNA levels were less than 10-fold the levels of the longer isoform The pharmacological characteristics of the isoforms are similar
Genscript Corporation B7-H3 4Ig /B7-H3b hFc Chimer
B7-H3 a member of the B7 family of immunomodulatory molecules is overexpressed in a wide range of solid cancers B7-H3 binds to activated T cells via an as yet unidentified receptor In assays using sub-optimal amount so anti-CD3 stimulation 2Ig B7 H3 enhances T cell proliferation T cell interferon-gamma (IFN-gamma) production and cytotoxic T cells induction
Amsbio LLC MIP-2 Leeporter™ Luciferase Reporter-RAW264.7 Cell Line
MIP-2 Leeporter™ Luciferase Reporter-RAW264.7 Cell Line
Amsbio LLC Human Merkel Cell Carcinoma FFPE tissue block
Human Merkel Cell Carcinoma FFPE tissue block
Eurofins Discoverx PathHunter Rhesus EDG5 β-Arrestin Cell-Based Assay Kit (CHO-K1)
The PathHunter Rhesus EDG5 β-Arrestin Stable Cell Line Assay (CHO-K1) contains a stable clonal cell line used to measure rhesus EDG5 (GPCR) activity via recruitment of β-Arrestin2. This is a complete kit that includes the cell vials and all required reagents needed for cell culture and running the assay.
ATCC PfizerPneumococcal polysaccharide powder Type 51 (d7F) 2mg
Purified pneumococcal polysaccharide type 7F is manufactured by Pfizer, Inc., for small-quantity distribution by ATCC. The pneumococcal powder type 7F is a component of the current 13-valent vaccine against Streptococcus pneumoniae. The pneumococcal polysaccharide type 7F can be used to assay for type-specific antibodies, research immune responses, and study immunodeficiencies.
Biochain Institute Inc Frozen Tissue Section - Arrhythmia, infarct: Heart Ventricle, left, 5 slides/PK
BioChain's tissue products are based on the sample repository network established following the IRB-approved ethical standard and procedures. BioChain's Frozen Tissue Slides are ideal for rapidly identifying cellular localization of RNA or protein. A single human adult normal tissue with 5-10 um thickness is mounted on a positively charged glass slide. The slides are fixed and dehydrated with acetone for consistent results with in situ hybridization and immunohistochemistry. More organs may be available upon request.
Eurofins Discoverx PathHunter U2OS mOPRM1 β-Arrestin Cell Line, 2 vials. (93-0524C3)
The PathHunter mOPRM1 cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. met 5-enkephalin) based activation of mOPRM1 GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged mOPRM1 and EA-tagged β-Arrestin-2. Activation of mOPRM1 stimulates the recruitment of β-Arrestin-2 and produces EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. Please note that this product expresses the Mouse version of this protein. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
Biochain Institute Inc Frozen Tissue Section - Arrhythmia, infarct: Heart, 5 slides/PK
BioChain's tissue products are based on the sample repository network established following the IRB-approved ethical standard and procedures. BioChain's Frozen Tissue Slides are ideal for rapidly identifying cellular localization of RNA or protein. A single human adult normal tissue with 5-10 um thickness is mounted on a positively charged glass slide. The slides are fixed and dehydrated with acetone for consistent results with in situ hybridization and immunohistochemistry. More organs may be available upon request.
Eurofins Discoverx ChemiScreen FFAR3/GPR41 Free Fatty Acid Receptor Stable Cell Line, 2 vials. (HTS135C)
The ChemiScreen FFAR3/GPR41 Free Fatty Acid Receptor Stable Cell Line is an engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. free fatty acids) based activation of FFAR3 GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses FFAR3 alongside endogenous high levels of the promiscuous G protein, Gα15, coupling the receptor to the calcium signaling pathway. Upon activation of FFAR3, the resulting calcium activity can be fluorescently assayed. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, visit www.discoverx.com/targets/gpcr-target-biology.
Eurofins Discoverx Ready-to-Assay FFA3/GPR41 Free Fatty Acid Receptor Frozen Cells, 2 Vials of Cells. (HTS135RTA)
The Ready-to-Assay FFA3/GPR41 Free Fatty Acid Receptor Frozen Cells are a simple, thaw-and-assay cell format for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This assay assesses ligand (e.g. free fatty acids) based activation of FFAR3 GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses FFAR3 alongside exogenous levels of a promiscuous G-protein, coupling the receptor to the calcium signaling pathway. Upon activation of FFAR3, the resulting calcium activity can be fluorescently assayed. Ready-to-assay kits consist of two vials of the stably modified clonal cell line in a convenient thaw-and-use format. For detailed product information, User manual and datasheet, visit www.discoverx.com/products-applications/frozen-cells.
Eurofins Discoverx PathHunter HEK 293 AVPR2 β-Arrestin Cell Line, 2 vials. (93-0187C1)
The PathHunter AVPR2 cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. vasopressin) based activation of AVPR2 GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged AVPR2 and EA-tagged β-Arrestin-2. Activation of AVPR2 stimulates the recruitment of β-Arrestin-2 and produces EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
Eurofins Discoverx PathHunter U2OS ACVR1B/BMPR2 Dimerization Cell Line, 2 vials. (93-1072C3)
The PathHunter ACVR1B/BMPR2 Dimerization cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting receptor-receptor interaction. This cell line enables assessment of ligand (e.g. activin A) induced dimerization of ACVR1B/BMPR2 receptors. This product uses EFC technology. The cell line included overexpresses ACVR1B target protein fused to PK alongside BMPR2 target protein fused to EA. Upon ligand-induced dimerization of ACVR1B/BMPR2 , detectable EFC signal is produced. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/kinases.
Vector Biolabs human CDK9 shRNA Adenovirus (Ad-h-CDK9-shRNA)
Ready to use in vivo grade AAV and Adenovirus Ready to use in vivo grade AAV and Adenovirus pre synthesized DNA vector High titer viral vectors 1/EA