General Cell Lines and Cell Cultures
Brainxell Inc Microglia (Human iPSC-Derived, Male Line, GFP Reporter, 2M)
Microglia derived from iPSC line WC-30, male. Contents: 1 vial of ≥2x10^6 viable cryopreserved cells. Ubiquitously expressing eGFP. Marker Expression: Confirmed expression of microglia surface markers including: CD45, CD11b, CX3CR1, P2RY12, and TMEM119. Immunocytochemistry shortly after plating microglia (shown here with a DAPI stain) reveals prominent expression of TREM2 (green) and IBA1 (red). Function: Human microglia demonstrate phagocytosis and can be stimulated to secrete a variety of cytokines. iPSC derived microglia are immunologically naive. Related diseases: Autism, Epilepsy, Multiple Sclerosis, Alzheimer's & Huntington's Disease.
Abcam Piribedil dihydrochloride, D2/D3 dopamine receptor agonist, 50MG
MW 371.27 g/mol, Purity >99%. D₂/D₃ dopamine receptor agonist. D₃ selectivity demonstrated in vitro. Improves attentional dysfunction in combination with L-DOPA.
The product is subject to the following: Abcam Restricted Use Statement
Brainxell Inc Spinal Motor Neurons (Human iPSC-Derived, Male Line, 1M)
Human spinal motor neurons derived from iPSC line WC-30, male. Contents: 1 vial of ≥1x10^6 viable cryopreserved cells. Marker Expression: Spinal Motor Neurons (BX-0100) have high neuronal purity (>80%) and consist of greater than 70% motor neurons. Labeling with the pan-neuronal marker MAP2 (green) and the motor neuron-specific marker FOXP1 (red) highlights the purity of this neuronal product. Function: Spinal Motor Neurons exhibit pronounced electrophysiological activity after two weeks in culture, as demonstrated by multi-electrode array (MEA) recordings. Related diseases: Amyotrophic Lateral Sclerosis (ALS), Spinal muscular atrophy (SMA), & Spinal Cord Injury. Primary neurotransmitter released: Acetylcholine
Abcam (R)-Baclofen (mM/ml), GABAB agonist, 25MM_ML
MW 213.66 Da, Purity >98%. More active enantiomer of selective GABAB agonist (R,S)-Baclofen (ab120149). Soluble in 1 ml water to give specified mM/ml concentration.
The product is subject to the following: Abcam Restricted Use Statement
Eurofins Discoverx PathHunter Jurkat PD-1 (SHP1) Signaling Assay, 2 vials. (93-1104C19)
The PathHunter PD-1 Checkpoint Signaling cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting signaling checkpoints. This cell line enables assessment of ligand (e.g. PD-L1, PD-L2) based activation of PD-1 receptors via detection of SH2 domain protein recruitment. The included cell line overexpresses ProLink-tagged PD-1 target protein and EA-tagged SH2 domain protein. Upon activation of the receptor by its ligand or an agonist antibody, recruitment of SH2 domain protein to the phosphorylated receptor tail leads to production of EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/checkpoint.
Cayman Chemical GABAA Receptor subunit NTe
Immunogen: Fusion protein from the N-terminal region of the δ subunit of rat GABAA receptor • Host: Rabbit • Species Reactivity: (+) Mouse and rat • Applications: ICC, IHC, and WB • GABAA-Rs are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases including epilepsy, anxiety, depression, and substance abuse. It is a multimeric subunit complex with six α's, four b’s, and four g’s, plus alternative splicing variants of some of these subunits. Several studies demonstrate that the d-subunit of the receptor may affect subunit assembly and may also confer differential sensitivity to neurosteroids and to ethanol.
ATCC Enterococcus faecalis; Strain AGR 329
Enterococcus faecalis strain AGR 329 is a drug-resistant bacterium that was isolated from piglet feces. This whole-genome sequenced strain is resistant to erythromycin and tetracycline; no vancomycin resistance genes were detected by PCR. It has applications for antimicrobial resistance research and drug development.
ATCC Salmonella enterica; subspecies enterica; serovar Enteritidis; Strain: SAP18-0432
Salmonella enterica subsp. enterica serovar Enteritidis strain SAP18-0432 was isolated in the United States from a human. This whole-genome sequenced bacterium was part of the 2018 PulseNet-GenomeTrakr joint proficiency test exercise. This strain has applications in infectious disease research and zoonotic disease research.
ATCC Merck Pneumococcal polysaccharide powder Type 57 (d19A) 10mg
This purified pneumococcal polysaccharides was manufactured by Merck & Company for small-quantity distribution by ATCC. The pneumococcal powders include types that are components of the current 23-valent vaccine against Streptococcus pneumoniae. Each of the polysaccharide antigens used in the polyvalent vaccine is extracted and purified separately. These vaccine products can be used to assay for type-specific antibodies, research immune responses, and study immunodeficiencies.
ATCC F-12K Medium
F-12K Medium (Kaighn's Modification of Ham's F-12 Medium) contains 2 mM L-glutamine and 1500 mg/L sodium bicarbonate. It has applications for cell culture, cell growth, and viability.
Biochain Institute Inc FDA Standard Frozen Tissue Array - Mouse Normal, 4 slides/PK
BioChain provides FDA Standard Frozen Tissue Array which is designed in conformance with FDA guideline and meeting the requirements for IHC (Immunohistochemistry) and IVD (In vitro Diagnostic Devices) certification. This tissue array has two slides which contain 30 different normal tissue types and 3 donors per tissue type.
ATCC IC-21; Peritoneal Macrophage; Mouse (Mus musculus)
IC-21 is a macrophage cell that was isolated from a mouse and can be used in immunology.
Biochain Institute Inc Matched Pair - cDNA - Human Primary and Matched Metastatic Tumor Tissue: Kidney, 10 x2 rxn /PK
BioChain's human cDNA matched pair products include: Primary Pair (PP), Primary and Metastasis Pair (PM). PP consists of cDNA prepared from primary tumor and its adjacent normal tissue; PM consists of cDNA prepared from primary tumor and corresponding metastatic tumor. cDNAs in each pair are prepared from the same donor. This product line is designed for identifying tumor-specific (or disease specific) genes and tumor metastatic genes.
Eurofins Discoverx ChemiScreen S1P5 Lysophospholipid Receptor Membrane Preparation, 1 vial. (HTS193M)
The ChemiScreen S1P5 Lysophospholipid Receptor Membrane Preparation is derived from proprietary stable recombinant cells to ensure high levels of S1PR5 surface expression. ChemiScreen membrane preps can be used to screen for GPCR activity using GTPγS assays. Increased GPCR activation levels will lead to higher radioactive signal. Membrane preps contain 1 mL of 1 mg/mL frozen membranes derived from a stably modified clonal cell line which was chosen for optimal receptor expression. For detailed product information, visit www.discoverx.com/membranepreps.