Sera
Cayman Chemical EpIpregnolon 50mg
A neurosteroid and an active metabolite of pregnenolone; inhibits spontaneous contractions in myometrial strips isolated from at-term pregnant women (IC50 = 156 µM); decreases operant alcohol self-administration in rats at 10 and 20 mg/kg
Cayman Chemical DegarelIxacetate 50mg
A synthetic GNRHR antagonist (IC50 = 3 nM in HEK293 cells expressing the human receptor); inhibits the growth of WPMY-1, WPE1-NA22, BPH-1, and LNCaP prostate cell lines via caspase activation and induction of apoptosis (10 μM); decreases plasma testosterone levels in rats to castrate levels for the first 49 days post treatment (2 mg/kg); decreases tumor volume of Dunning R3327H prostate tumor flank implants in rats (1 mg/kg per month)
Cayman Chemical CYPERMETHRIN 100MG
A type II pyrethroid insecticide; prolongs opening of sodium channels resulting in membrane depolarization and a conductance block of the insect nervous system; reduces survival of ticks in vitro (1-1.5 mg); reduces survival of lice in sheep fleece and prevents re-infestation in contact-challenged sheep (5 and 10 ppm); induces developmental neurotoxicities in zebrafish (50 to 200 μg/L); induces Parkinson's disease-like neurodegeneration in rats (15 mg/kg twice weekly for 24 weeks)
Cayman Chemical LevonrdefrIn 100mg
A vasoconstrictor; (–)-enantiomer of nordefrin; rapidly increases blood pressure and heart rate in anesthetized dogs (1-5 UG/kg); in combination with mepivacaine, increases systolic arterial blood pressure in anesthetized dogs (0.514 and 1.542 mg/kg)
Cayman Chemical 5methyl2HOBAhydrochlorId 50mg
An isoketal scavenger; reduces angiotensin II-induced increases in systolic blood pressure in mice
Cayman Chemical NAmIdInoLaspartIc AcId 100mg
A guanidino compound with epileptogenic activity; induces whole-cell currents in rat hippocampal slices; intrahippocampal administration induces status epilepticus and neuronal cell death in rats
Cayman Chemical 5 7 3 4Tetramethoxyflavon 50mg
A flavone with diverse biological activities; selectively inhibits MRP1 over MRP2 (IC50s = 7.9 and >50 µM, respectively); inhibits LPS-induced nitric oxide (NO) release in primary mouse peritoneal macrophages from 0.03-30 µM; active against P. falciparum (IC50 = 4.06 UG/ml); is cytotoxic to B16/F10 melanoma cells at 20 µM; inhibits IL-33-induced production of CCL2 and CCL5 in primary human mast cells at 50 and 100 µM; decreases the synovial fluid levels of PGE2, IL-1β, and TNF-α in a rat model of surgically induced osteoarthritis at 100 mg/kg
Cayman Chemical ML-241hydrochlorIde 50mg
A selective inhibitor of p97 (IC50 = 0.11 µM); selective for the p97 D2 domain; disrupts the ERAD pathway, preventing the degradation of p97-dependent proteasome substrates in a reporter assay using HeLa cells (IC50 = 3.5 µM) and inducing the accumulation of ubiquitin conjugates in the nuclear plus membrane and cytosolic compartments of SW403 cells at 5 and 10 µM
Cayman Chemical AcetylharpagIde 50mg
An iridoid glycoside with diverse biological activities; reduces the proliferation of A431 cancer cells (IC50 = 310 µM); reduces the number of tumors per mouse and the percentage of mice with tumors in a mouse model of 4-nitroquinolin 1-oxide-induced carcinogenesis at 0.005% in the drinking water; decreases carrageenan-induced paw swelling in rats at 10 mg/kg; reduces blood glucose levels in a mouse model of alloxan-induced type I diabetes at 10 mg/kg
Cayman Chemical ADL5859hydrochlorIde 50mg
A δ-opioid receptor agonist (Ki = 0.84 nM); selective for δ-opioid receptors over μ-opioid and κ-opioid receptors at 10 μM; completely reverses CFA-induced mechanical hyperalgesia in rats at 3 mg/kg; decreases immobility time in the forced swim test in rats
Cayman Chemical RopIdoxurIdIn 50mg
A radiosensitizer and a prodrug form of idoxuridine; inhibits viral plaque formation in HSV-1- or HSV-2-HeLa infected cells at 100 µM; enhances radiation-induced decreases in tumor growth without reducing body weight in an HT-29 colon cancer mouse xenograft model at 1,000 mg/kg per day for six days; increases animal survival in a mouse model of lethal HSV-2 infection at 100 mg/kg every five days