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An antibiotic; active against macrolide-resistant R. equi and S. zooepidemicus (MIC90s = 1 and 0.125 μg/ml, respectively); reduces the number of pneumonic lesions in a bovine M. haemolytica challenge model at a dose of 6 mg/kg
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A 5-HT3 receptor antagonist (Ki = 0.8 nM for the mouse receptor); selective for 5-HT3 over 5-HT4 (Ki = 156 nM for the porcine receptor); an antagonist of the α9 nAChR (IC50 = 166 nM for the rat receptor); a partial agonist of α7 nAChR (Ki = 6.9 nM for the rat receptor); enhances glycine-induced potentiation of homomeric α1 but not homomeric α2 glycine receptors at 10 µM; blocks 5-HT-induced depolarizations in isolated rabbit nodose ganglia at 0.1 nM; exhibits anti-emetic effects in a ferret model of cisplatin-induced emesis at 1 mg/kg
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A dihydrofolate reductase inhibitor that prevents the production of tetrahydrofolic acid in P. falciparum and other protozoa; displays a prophylactic effect (ED50 = 0.5 mg/kg) in in vivo antimalarial mouse models
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A dihydropyridine used as an antihypertensive agent due to its ability to block L-type and T-type calcium channels; also binds to adenosine A1, A2A, and A3 receptors with Ki values of 8.96, 23.0, and 8.3 µM, respectively
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A stable and efficient hole-transport material in organic light-emitting devices and in ssDSSCs; yields high ssDSSC efficiency due to its excellent pore-filling property into mesoporous titania films
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A medium-chain acylcarnitine; decreases the oxidation rate of 3-methyl-2-butanoate and 4-methyl-2-oxopentanoate in isolated rat muscle mitochondria in the presence of carnitine, but increases it in the absence of carnitine; with malate, has been used as a mitochondrial respiration substrate along with malate to measure the effect of creatine on the respiration rate of isolated rat cardiac fibers exposed to increasing concentrations of ADP
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A selective antagonist of the dopamine D1-like receptor subtypes D1 and D5 (Kis = 0.2 and 0.3 nM, respectively); useful for studying the role of the dopamine system in normal brain function and neurological disorders
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An H+/K+-ATPase inhibitor; reversibly inhibits the activity of the H+/K+-ATPase in an enzyme assay; inhibits histamine-induced gastric acid secretion in rats at 30 mg/kg, s.c.
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