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An antidepressant; selectively inhibits norepinephrine uptake over 5-HT uptake in rat hypothalamic synaptosomes (IC50s = 0.9 and >100 µM, respectively); decreases immobility time in the forced swim test in mice at 8 and 16 mg/kg
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There are five immunoglobulin classes in humans. Out of these immunoglobulin M (IgM) is a high molecular weight protein that has five or six subunits. IgM monomers are made of two heavy chains and two light chains connected by a disulfide bond. Human serum shows low concentration of IgM monomers. It has a high carbohydrate content of about 12%. It is the first immunoglobulin produced by neonates.IgM antibodies are present as pentamers in the serum and are produced in response to antigens.IgM from human serum is purified from normal human serum by precipitation and gel filtration techniques. The immunoglobulin is determined to be atleast 95% pure by HPLC procedures.
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An analytical reference standard categorized as a muscle relaxant; has been found as an impurity in seized heroin; intended for research and forensic applications
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Small and Specialty Supplier Partner Small and/or specialty supplier based on Federal laws and SBA requirements. Learn More
A β2-AR agonist; selectively induces cAMP accumulation in CHO cells expressing the β2-AR over the β1- and β3-ARs (EC50s = 0.4, 398, and 794 nM for the human receptors, respectively); inhibits contractions induced by electrical stimulation in isolated superfused guinea pig trachea strips; inhibits histamine-induced bronchospasms in guinea pigs when administered via nebulization (EC50 = 30 µM)
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Small and Specialty Supplier Partner Small and/or specialty supplier based on Federal laws and SBA requirements. Learn More
A pyranocoumarin with diverse biological activities; inhibits RANKL-induced osteoclastogenesis of primary mouse BMDMs at 10 µM and LPS-induced NO production in RAW 264.7 macrophages at 100 µM; inhibits PAF-induced platelet aggregation in isolated rabbit platelet-rich plasma (IC50 = 50 µM) and contractions of isolated guinea pig ileum induced by histamine or leukotriene D4 (pD2s = 4.84 and 4.34, respectively); decreases ovariectomy-induced bone loss in a mouse model of osteoporosis at 10 mg/kg; reduces the number of tumors initiated by DMBA and promoted by TPA in a mouse two-stage model of skin carcinogenesis
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More