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A neonicotinoid insecticide; an antagonist of nAChRs (IC50 = 2.7 nM for the D. melanogaster enzyme); lethal to D. melanogaster (LD50 = 0.03 mg/kg); toxic to mice (LD50 = 28 mg/kg)
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A natural non-caloric sweetener; inhibits glucose transport by Glut 1 and fructose transport by Glut5 (IC50s = 4.6 and 6.7 mM, respectively, for the recombinant human transporters); prevents palmitic acid-induced lipotoxicity in INS-1 mouse insulinoma cells at 50-200 µM; has been used to enhance the solubility of etoposide
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An antitumor antibiotic that induces apoptosis in mature monocytic U937 and myelocytic HL-60 acute myeloid leukemia cells at 0.2-1 μM; triggers a ROS-dependent sphingomyelin-ceramide pathway that activates the MEKK1-SEK1-JNK
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A class III antiarrhythmic agent; inhibits IKr in AT-1 myocytes (IC50 = 20 nM); enhances INa and increases the action potential duration in isolated guinea pig ventricular cells; decreases pinacidil-induced ventricular fibrillation in Langendorff isolated perfused rabbit hearts from 3-30 µM; increases the ERP of the left and right atrium in anesthetized pigs at 15 UG/kg, i.v.; prevents rapid pacing-induced atrial flutter in dogs from 0.25-5 mg/kg
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An amine-reactive fluorescent probe; has commonly been used as a reagent in fluorometric protein assays; has commonly been used as a reagent in fluorometric protein assays; displays excitation/emission maxima of 370/488 nm, respectively, in acetone
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A nonpeptide angiotensin II receptor antagonist which selectively and insurmountably inhibits the angiotensin II AT1 receptor subtype (Ki = 3.7 nM); a partial agonist of PPARγ, activating the receptor to 25-30% of that produced by the full agonist rosiglitazone (EC50 = 4.5 μM); potently reduces blood pressure
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