Human Sera
Cayman Chemical Esmolol AcIdhydrochlorIde 50mg
An active metabolite of isotretinoin increases protein expression of CK7 and CK19 in normal human epidermal keratinocytes at 10 UM inhibits proliferation of retinoid-sensitive UM-SCC-22A and UM-SCC-35 HNSCC cells has been found in influent and effluent wastewater is teratogenic to embryos when administered to pregnant dams at 100 mg/kg on day 11 of gestation
Cayman Chemical 7 DIethylamInocoumarIn3ca 50mg
A glycolipid TLR4 antagonist inhibits lipid A-induced TLR4 activation in a cell-based assay (IC50 5 013 UM) reduces LPS-induced lethality in mice at 10 mg/kg decreases angiotensin II-induced aortic expansion and rupture as well as the incidence of abdominal aortic aneurysms in ApoE-/- mice at 3 mg/kg
Cayman Chemical HydrocortIson Aceponate 50mg
A flavonoid glycoside with diverse biological activities inhibits RANKL-induced osteoclastogenesis in RAW 264 7 cells at 5 UM inhibits Aurora B kinase (IC50 11 07 UM in a cell-free assay) as well as Aurora A kinase and RSK2 at 20 UM induces cell cycle arrest at the G2/M phase and apoptosis in HGC-27 cells decreases LDH release induced by DL-buthionine (SR)-sulfoximine in primary rat cortical cells (IC50 7 4 Ug/ml) reduces acetic acid-induced writhing in mice
Cayman Chemical FlucloxacIlInsodIum salt 100mg
A flavonoid glycoside with diverse biological activities protects lard from thermal oxidation at 0 02 and 0 04 inhibits carrageenin-induced edema and yeast-induced fever in rats decreases serum levels of triglycerides and LDL as well as increases serum HDL levels in a rat model of high-fat diet-induced atherosclerosis at 20 and 50 mg/kg
Cayman Chemical ErlotInIbhydrochlorIde 50mg
A carbohydrate starting material has been used as a starting material in the synthesis of L-nucleoside-based anti-HIV agents
Cayman Chemical DIhydrojasmonIc AcId 100mg
A fluorescent membrane potential indicator displays excitation/emission maxima of 490/516 nm respectively has been used to measure the membrane potential of live or fixed mammalian and bacterial cells by flow cytometry or fluorescence microscopy
Cayman Chemical 3 6-DIsInapoylsucrose 50mg
A very long-chain saturated fatty acid a component of D-003
Cayman Chemical 2 6-XylIdInhydrochlorIde 50mg
An analytical reference standard that is structurally similar to known phytocannabinoids a metabolite of 9-hexahydrocannabinol intended for research and forensic applications
Cayman Chemical ChlorphensIn Carbamate 100mg
An inhibitor of Src MET and FMS kinases (IC50s 0.12 0.14 and 0.76 nM respectively) inhibits the proliferation of MKN45 and SNU-5 human gastric cancer cells (IC50s 0.2 and 0.17 nM respectively) as well as Ba/F3 pro-B cells expressing TEL-CSF1R (IC50s 19.3 nM) inhibits cell migration of HCC827 cells at 100 nM inhibits tumor growth in a MKN45 mouse xenograft model at 10 and 30 mg/kg inhibits phosphorylation of MET at Tyr1234 and Tyr1349 in the same model at 10 mg/kg
Cayman Chemical PalIperIdon PalmItate 100mg
A diterpenoid with diverse biological activities inhibits induction of EA-EBV by TPA in Raji cells (IC50 25.2 M) active against the plant pathogenic fungus V. mali (IC50 18 mg/L) dermal application (3.3 Umol) reduces the tumor promoting effects of TPA on 712-demethylbenz[a]anthracene-induced papilloma formation by 53 in mice has been found in cigarette smoke condensate
Cayman Chemical DexmedetomIdIn 100mg
An inhibitor of SARS-CoV-2 Mpro (Ki 3.11 nM) inhibits Mpro from SARS-CoV-1 HKU1-CoV OC43-CoV and MERS-CoV (Kis 4.94 189 36.4 and 187 nM respectively) as well as Mpro from NL-63-CoV and 229E CoV (Kis 226 and 44.4 nM respectively) selective for these enzymes over several other proteases including human and HIV-1 proteases (IC50s 100 UM for all) as well as a panel of G protein-coupled receptors kinases and transporters (IC50s ≥100 UM for all) inhibits SARS-CoV-2 replication in A549 cells (EC50 77.9 nM) and reduces the cytopathic effect of SARS-CoV-2 in infected Vero E6 cells (EC50 74.5 nM) reduces lung viral titers and the severity of pulmonary lesions in mice infected with the mouse-adapted SARS-CoV-2 MA10 variant at 300 and 1000 mg/kg
Cayman Chemical 7 pMethoxybenzylamIno4nI 50mg
A biologically active form of vitamin E inhibits the growth of DU145 LNCaP and Caco-2 cancer cells at 25 UM reduces airway eosinophil infiltration and levels of IL-6 IL-5 IL-13 and CCL2 in a rat model of ovalbumin-induced allergic inflammation and a rat model of ovalbumin- and ozone-induced asthma at 100 mg/kg reduces lipid peroxidation in vitamin E-depleted iron-loaded rats
Cayman Chemical PIcoxystrobIn 100mg
A pyrimidine nucleotide used in the synthesis of RNA an intermediate in the synthesis of phospholipids
Cayman Chemical CnabIgerol 50mg
An internal standard for the quantification of N-nitroso desloratadine by GC- or LC-MS
Cayman Chemical 7-KetosItosterol 50mg
An internal standard for the quantification of ursocholic acid by GC- or LC-MS