Human Sera
Lonza Walkersville PyroCell Monocyte Activation Test - Human Serum Kit - 3 vials cryopreserved, pooled PBMC (human, pMAT cells), 3 vials of cryopreserved Human Serum Supplement, for 288 tests (3x 96-well plates).
The Monocyte Activation Test (MAT) is an in vitro assay for pyrogen testing in pharmaceutical and medical device industries. The principle of the Monocyte Activation Test is based on the detection of inflammatory cytokines released by human monocytes in response to exogenous bacterial endotoxin (LPS) and non-endotoxin pyrogens (NEP). Since its first adoption by the European Pharmacopeia in 2010 (Ph. Eur. chapter 2.6.30) the Monocyte Activation Test is recognized as a compendial method for pyrogen testing in several world regions including Europe. Here, the Monocyte Activation Test is recommended as a replacement test for the Rabbit Pyrogen Test (RPT). Here, the Monocyte Activation Test is the compendial method for pyrogen testing following the discontinuation of the Rabbit Pyrogen Test. The Monocyte Activation Test also complies with EU Directive 2010/63/EU on the protection of experimental animals.
Cayman Chemical BCIPp-toluIdIn salt 100mg
A colorimetric substrate for alkaline phosphatase; can be used to detect alkaline phosphatase activity by IHC or WB
Cayman Chemical TrImeprazIntartrate 100mg
A histamine H1 receptor antagonist (Ki = 0.72 nM in a radioligand binding assay); selective for the histamine H1 receptor over mAChRs (Ki = 38 nM in a radioligand binding assay); inhibits anti-IgE-induced histamine release from isolated human lung fragments (IC50 = 19 nM) but induces histamine release (RC50 = 1.03 µM); reduces SARS-CoV-2 replication in SARS-CoV-2-infected Vero E6 cells (EC50 = 1.76 µM) with a CC50 value of 19.73 µM
Cayman Chemical Hydroxytyrosol Acetate 50mg
A polyphenol with diverse biological activities; scavenges DPPH radicals in a cell-free assay (IC50 = 1.73 µM); active against V. parahaemolyticus (MIC = 39 UG/ml); inhibits LPS-induced increases in NO, iNOS, and COX-2 levels in isolated mouse peritoneal macrophages at 50 or 100 µM; inhibits hypoxia- and reoxygenation-induced LDH release in isolated rat brain slices; inhibits paw swelling, joint synovial hyperplasia, and cartilage erosion in a mouse model of collagen II-induced rheumatoid arthritis at 0.05% in the diet; decreases serum levels of IgG1, IgG2a, MMP-3, and COMP, as well as levels of TNF-α, IL-1β, IFN-γ, IL-6, IL-17a, and PGE2 in hind paw joint homogenates, in the same model
Cayman Chemical 5 4 6DIchlorostrIazIn2y 50mg
An amine-reactive fluorescent protein-labeling agent; has been conjugated to IgG for use as fluorescent antibodies and as a pre-column or on-column reagent to label amino acids and amino acid-containing compounds; has been used as a derivatizing agent in the analysis of ephedrine and pseudoephedrine; ex/em = 492/513 nm, respectively
Cayman Chemical N-OxalylglycIn 100mg
A cell permeable inhibitor of α-ketoglutarate-dependent enzymes, including JMJD2A, JMJD2C, and JMJD2E (IC50s = 250, 500, and 24 μM, respectively); inhibits the prolyl hydroxylase domain-containing proteins PHD1 and PHD2 with IC50 values of 2.1 and 5.6 μM, respectively
Cayman Chemical Incensole Acetate 50mg
A diterpene with diverse biological activities; a TRPV3 activator (EC50 = 16 µM for inducing calcium influx in HEK293 cells expressing TRPV3); inhibits IκBα degradation in TNF-α-stimulated HeLa cells at 60-140 µM; reduces amyloid-β (25-35) peptide-induced apoptosis, increases in MDA levels, and the production of ROS; reduces paw edema in a mouse model of hind paw inflammation at 50 mg/kg; has anxiolytic and antidepressant-like activity in mice
Cayman Chemical RopIdoxurIdIn 50mg
A radiosensitizer and a prodrug form of idoxuridine; inhibits viral plaque formation in HSV-1- or HSV-2-HeLa infected cells at 100 µM; enhances radiation-induced decreases in tumor growth without reducing body weight in an HT-29 colon cancer mouse xenograft model at 1,000 mg/kg per day for six days; increases animal survival in a mouse model of lethal HSV-2 infection at 100 mg/kg every five days
Cayman Chemical PIrfenIdon 100mg
An orally bioavailable pyridone derivative with antifibrotic, anti-inflammatory, and antioxidant activities; inhibits TGF-β1-stimulated increases in collagen type I, fibronectin, and Hsp47 expression in A549 lung cancer cells in a concentration-dependent manner; inhibits fibrosis and inhibits increases in collagen content, fibrocyte pool size, and the levels of chemokines CCL2 and CCL12 at 300 mg/kg in lung in a mouse model of pulmonary fibrosis induced by bleomycin; inhibits fibrosis and increases in hepatocyte apoptosis, lobular inflammation, and hepatic expression of the fibrosis-related genes Col1a1, Timp1, Tgfb1, Pdgfb, and Fgf2 in a mouse model of NASH at 280 mg/kg; inhibits NADPH-dependent lipid peroxidation in sheep liver microsomes and scavenges hydroxyl radicals (IC50s = ~6 and ~2.5 mM, respectively)
Cayman Chemical -FluvalInate 50mg
A pyrethroid acaricide; induces tail currents in AmNav1 and VdNav1 channels expressed Xenopus oocytes (EC50s = 60 and 160 nM, respectively) with a faster tail current decay in VdNav1 channels; topical application at 2 µl in combination with coumaphos, atrazine, 2,4-DMPF, chlorpyriphos, and chlorothalonil does not affect honeybee queen mass, egg-laying patterns, or the mass of daughter worker bees at emergence
Cayman Chemical StevIosIdehydrate 50mg
A natural non-caloric sweetener; increases glucose-stimulated insulin secretion in isolated mouse pancreatic islets at 1 µM; reduces LPS-stimulated increases in TNF-α and IL-1β production in THP-1 cells, but also induces TNF-α and IL-1β production in unstimulated THP-1 cells at 1 mM; decreases systolic blood pressure in GK type 2 diabetic rats at 0.03 g/kg; reduces TPA-induced EAr edema in mice (ID50 = 291.6 UG/ear)
MOLECULAR DEPOT LLC Glucuronidase-ArylSulf. 5 mL
b-Glucuronidase/Arylsulfatase from Helix pomatia is an enzymatic bend of -Glucuronidase and Arylsulfatase from Helix pomatia with each enzyme having an activity of at least 3500 U/mL This product has been used as molecular tool for various biochemical applications It has also been used in a wide array of other chemical and immunological applications For in vitro research use only