Human Sera
Cayman Chemical PropacetamolhydrochLRIde 100mg
An inhibitor of Nav1 7 (IC50 0 17 UM) selective for Nav1 7 over hERG/Kv11 1 Nav1 5 and Nav1 8 (IC50s 10 1 1 and 2 2 UM respectively) but does inhibit Nav1 3 and Nav1 4 (IC50s 0 3 and 0 4 UM respectively) inhibits formalin-induced flinching in a rat model of persistent pain at 20 and 30 mg/kg increases latency to paw withdrawal in a hot plate test in a mouse model of CFA-induced inflammatory pain
Cayman Chemical PhenylacetylglycIn 50mg
A coumarin inhibits vitamin K1 epoxidation and prothrombin synthesis by 18 and 67 respectively in cell-free assays at 6 2 mM has been used in the synthesis of anticoagulants as well as antithrombotic anti-inflammatory antibacterial and antifungal agents
Cayman Chemical BrequInarsodIum salt 100mg
Immunogen Recombinant human IL-6 protein Host Mouse Species Reactivity ( ) Human Cross Reactivity ( ) Human IL-6 Applications IHC WB MW 24 kDa
Cayman Chemical CephalotaxIn 50mg
Immunogen Mouse IgG2b Host Rabbit Species Reactivity ( ) Mouse Cross Reactivity ( ) IgG2b (-) Mouse IgG1 IgG2a IgG3 IgM IgA IgE (-) Human goat rat IgG Applications ELISA WB MW 150 and 50 kDa for non-reduced and reduced mouse IgG1 respectively
Cayman Chemical SyrosngopIn 50mg
Immunogen Peptide from the N-terminal region of human paxillina/B/Y Host Rabbit Species Reactivity ( ) Human Applications ICC WB
Cayman Chemical StevIolbIosIde 50mg
An antioxidant heavy metal chelator prevents methylmercury-induced GSH loss and cytotoxicity to isolated mouse aortic endothelial cells at 50 UM prevents ROS production and cytotoxicity induced by bleomycin in primary bovine pulmonary artery endothelial cells at 50 UM increases survival of rats in a model of mercury chloride-induced toxicity at 2 mg/kg
Cayman Chemical Nethyl PRfluoroctnsulfon 100mg
A dopamine D3 receptor agonist selective for dopamine D3 over dopamine D2 receptors (EC50s 38 and 10000 nM respectively inBarrestin recruitment assays using CHO-K1 cells expressing the human receptors) dopamine D1 D4 and D5 receptors and a panel of 45 GPCRs transporters and ion channels at 10 UM inhibits forskolin-induced cAMP accumulation in HEK293 cells expressing the human dopamine D3 receptor (IC50 86 nM) induces phosphorylation of ERK in CHO-K1 cells expressing the human dopamine D3 receptor (EC50 21 nM) protects against 6-OHDA-induced cell death in human iPSC-derived cells differentiated into dopaminergic neurons at 50 nM
Cayman Chemical 5a-ndrostn-3-ol 50mg
Host Mouse Cross Reactivity human and mouse TIF1 Applications ELISA ICC IHC WB
Cayman Chemical ChIkusetsusaponIn IVa 50mg
A triterpene saponin with diverse biological activities inhibits HIV-1 protease (IC50 50 UM) inhibits carrageenan-induced paw edema in rats and compound 48/80-induced scratching behavior in mice from 50-200 mg/kg inhibits ethanol absorption and increases glucose tolerance in rats decreases mucosal lesion size and severity in a rat model of ethanol-induced gastric ulcers from 10-50 mg/kg
Cayman Chemical ntImycIn A Complex 50mg
An ERK inhibitor (IC50 2 7 nM for ERK2) selective for ERK over a panel of 465 kinases reduces RSK phosphorylation in mutant B-RAF-expressing A375 melanoma and mutant K-Ras-expressing HCT116 colorectal cancer cells (IC50s 3 3 and 4 nM respectively) inhibits proliferation in a panel of cancer cell lines including melanoma colorectal and lung cancer cells reduces tumor growth in A375 Calu-6 and COLO 205 mouse xenograft models
Cayman Chemical MELK-8ahydrochlorIde 50mg
An antiviral agent inhibits replication of wild-type HBV and drug-resistant HBV strains rtA181T rtA181V and rtN236T (IC50s 146 145 161 and 131 nM respectively) inhibits the formation of viral capsids and decreases viral core protein levels in HBV-infected HepG2 and HepG2.2.15 cells at 1 and 10 UM inhibits HBV replication and reduces the levels of viral intracellular core antigens in mice inoculated with HepAD38 cells at 7.5-60 mg/kg
Cayman Chemical PyraclostrobIn 50mg
A ruthenium complex with anticancer activity cytotoxic to HT-29 and SW480 cells (IC50s 24.46 and 123.3 UM respectively) induces mitochondrial apoptosis in SW480 cells reduces tumor growth in a SaI/N murine fibrosarcoma model at 10.5 21 and 42 mg/kg
Cayman Chemical 4 2ACtoxyACtylphenyl AC 50mg
A flavonoid aglycone inhibits the Kv1.3 channel in a patch-clamp assay at 30 UM cytotoxic to human LNCaP prostate Lu1 lung and MCF-7 breast cancer cells (EC50s 6.7 4.7 and 1.1 UM respectively)