Human Sera
Cayman Chemical 13 E-DocosenoIc AcId 50mg
A 22-carbon monounsaturated fatty acid; the trans isomer of 13(Z)-docosenoic acid
Cayman Chemical FerroprotoporphyrIn 50mg
An iron-containing cofactor; involved the transport or storage of oxygen by hemoglobin or myoglobin, respectively, electron transfer by cytochrome b5, and oxidation of xenobiotics or endogenous substrates by CYPs
Cayman Chemical OctacosnoIc AcId 100mg
A very long-chain saturated fatty acid and the major component of D-003
Cayman Chemical TrImethadIon 50mg
An anticonvulsant; decreases the levels of α-oxoglutarate, malate, and fumarate in the brain, as well as plasma glucose levels in rats; increases latency to first pentetrazole-induced clonic seizure in mice (ED50 = 10 mg/kg); inhibits absence-like seizures but not tonic convulsions in spontaneously epileptic rats
Cayman Chemical DorsomorphIn 50mg
A potent, reversible inhibitor of AMPK (Ki = 109 nM); dose-dependently inhibits the bone morphogenetic protein type 1 receptors ACTR-I (ALK2), BMPR-IA (ALK3), and BMPR-IB (ALK6); downregulates the Akt/mTOR pathway to induce autophagy in U251 human glioma cells
Cayman Chemical 4NItrophenyl DCelobIosId 50mg
An enzyme substrate; has been used to characterize function of endoglucanase 1 from T. harzianum, β-glucosidase from T. xylanolyticum, and GH3 aryl β-glucosidases from A. oryzae
Cayman Chemical FosInoprIlsodIum salt 100mg
A prodrug form of fosinoprilat; inhibits angiotensin I-induced pressor responses in normotensive rats, dogs, and monkeys at 15, 15, and 10 µmol/kg, respectively; reduces fractional shortening and decreases left ventricular size in a porcine model of congestive heart failure at 2.5 mg/kg
Cayman Chemical IsotretInoIn 50mg
A retinoid; increases the doubling time and transcription of RARβ mRNA in various human oral squamous cell carcinoma cells at 1 μM; inhibits proliferation of primary human sebocytes (IC50 = 10 μM); decreases triglyceride, stearyl ester, and free fatty acid synthesis and modulates keratin expression in primary human sebocytes at 0.1 μM; reduces chronic rejection damage and decreases mRNA expression of IFN-γ and IL-10 in allografts in chronic Fisher344➛Lewis transplant mice at 2 mg/kg per day; slows rod and cone recovery and prevents light-induced photoreceptor damage in an albino rat model of photoreceptor degeneration at 40 mg/kg
Cayman Chemical Isoalntolacton 50mg
A sesquiterpene lactone with diverse biological activities; inhibits proliferation of PANC-1, BxPC-3, and HPAC pancreatic cancer cells (IC50s = 40, 43, and 48 µM, respectively); induces apoptosis, cell cycle arrest at the S phase, and the production of ROS in PANC-1 cells; decreases LPS-induced production of NO, PGE2, IL-6, and TNF-α in RAW 264.7 macrophages at 4 and 8 µM; reduces production of S. aureus α-toxin in a concentration-dependent manner and increases survival in a mouse model of S. aureus-induced pneumonia at 50 mg/kg
Cayman Chemical Arformoteroltartrate 50mg
A β2-AR agonist; selectively binds to β1- over β2-ARs (Kds = 2.9 and 113 nM, respectively) as well as β3-adrenergic, B2 bradykinin, NK1 and NK2 receptors up to 3 μM; induces cAMP accumulation in cultured human bronchial epithelial cells; relaxes guinea pig tracheal strips precontracted with carbamoylcholine, ovalbumin, or histamine (pD2s = 8.4, 9.5, and 9.5, respectively); reverses histamine- and ovalbumin-induced bronchoconstriction in guinea pigs (ED50s = 1 and 40 nmol/kg, respectively)
Cayman Chemical AcetophenazInmaleate 50mg
A typical antipsychotic; binds to 5-HT6 and 5-HT7 receptors and the androgen receptor (Kis = 72, 2.4, and 800 nM, respectively); inhibits the binding of SKF 10047 (Ki = 36 nM) and spiperone (IC50 = 17 nM) to guinea pig brain membranes; increases the duration of fighting and the latency to submission in mice
Cayman Chemical 14-nhydrodIgItoxIgenIn 50mg
A cardenolide; reduces the activity of guinea pig heart Na+/K+-ATPase by 15% at 10 µM
Cayman Chemical 4ndrosten11ol3 17dIon 50mg
A non-androgenic steroid; metabolized to various androgenic 5α-reduced C19 steroids in LNCaP cells
Cayman Chemical SRT 3025hydrochlorIde 50mg
A SIRT1 activator; increases SIRT1 levels in, and inhibits RANKL-induced osteoclastogenesis of, mouse BMDMs at 2 µM; inhibits proliferation of SU.86.86 cells (IC50 = 0.98 µM); decreases plasma levels of LDL, VLDL, and total cholesterol in ApoE-/- mice fed a high-cholesterol diet at 3.18 g/kg