Human Sera
AdipoGen BioStab Antibody Stabilizer
Free or conjugated antibodies are often used in immunoassays, either in the system specific detector antibody plus streptavidin-HRP or in the system analyte-specific antibody plus species-specific antibody-HRP-conjugate. Both systems allow a high flexibility at lower costs. BioStab Antibody Stabilizer dramatically extends the life of your valuable antibodies, allowing much more consistent results over extended periods of time compared to daily prepared dilutions. BioStab Antibody Stabilizer can be used in ELISA, Western Blotting, Immunohistochemistry and any other applications which require marker or biotinylated antibodies. It is supplied as a ready-to-use solution for dilution of antibodies. This stabilizer contains a minimum amount of a surfactant. The stabilizer is free of any protein to minimize potential unspecific interactions. The method below is strongly recommended for standard assay procedures and reduces loss of valuable conjugates and assay-to-assay variations.
Cayman Chemical Clevdpn 50mg
An inhibitor of L-type calcium channels (IC50s = 7.1 and 78.8 nM at -40 and -80 mV, respectively, in isolated guinea pig cardiomyocytes); preferentially inhibits L-type calcium channels in isolated rat portal vein over rat left ventricle (IC50s = 427 and 20,417 nM, respectively); decreases mean arterial pressure in anesthetized normotensive or spontaneously hypertensive rats (ED30s = 316 and 58 nmol/kg, respectively)
Cayman Chemical socorydn 50mg
An aporphine alkaloid; reduces the action potential duration and amplitude in isolated canine Purkinje fibers at 100 µM; induces relaxation of norepinephrine-precontracted isolated rabbit aortic strips (EC50 = 12.6 µM); cytotoxic to A549 lung cancer cells (IC50 = 197.73 µM), as well as Huh7, HepG2, SNU-449, and SNU-387 hepatic cancer cells (IC50s = 161.3, 148, 262.2, and 254.1 UG/ml, respectively); reduces tumor growth in a Huh7 mouse xenograft model when used in combination with doxorubicin
Cayman Chemical Josamycn 100mg
A macrolide antibiotic; active against clinical isolates of the Gram-positive aerobic bacteria (MIC50s = ≤0.39 UG/ml for all), as well as Gram-negative anaerobic bacteria at 6.25 UG/ml; increases survival in mouse models of systemic S. aureus, S. pyogenes, and S. pneumoniae infection (ED50s = 206.8, 205, and 86.7 mg/kg, respectively)
Cayman Chemical ValrocemIde 100mg
An anticonvulsant; protects against MES-, PTZ-, picrotoxin-, or bicuculline-induced seizures in mice (ED50s = 151, 132, 275, and 248 mg/kg, respectively); prevents sound-induced seizures in Frings audiogenic-sensitive mice (ED50 = 52 mg/kg) and MES-induced seizures in rats (ED50 = 73 mg/kg); prevents seizures in corneally kindled rats (ED50 = 161 mg/kg)
Cayman Chemical DIoctnoyl Glycol 50mg
A DGK inhibitor (Ki = 58 μM); reduces basal and thrombin-stimulated phosphatidic acid levels in washed isolated human platelets at 30, 100, and 500 μM
Cayman Chemical ToltrazurIl sulfon 50mg
An active metabolite of toltrazuril; formed from toltrazuril via the intermediate metabolite toltrazuril sulfoxide by CYP enzymes, including CYP3A; inhibits T. gondii tachyzoite production in African green monkey kidney cells at 0.1, 1, and 5 UG/ml; completely prevents infection with T. gondii tachyzoites in a mouse model of fatal toxoplasmosis at 10 or 20 mg/kg one day prior to, and daily for 10 days following, infection; reduces the number of infected mice in the same model at 10 mg/kg for 11 days starting six days following infection
Cayman Chemical scylo-InosItol 100mg
A stereoisomer of inositol; reduces Aβ40- and Aβ42-induced decreases in the survival of PC12 cells at 0.1-2 UG/µl; reduces increases in soluble and insoluble brain Aβ40 and Aβ42 levels in four- and six-month-old mice in the TgCRND8 model of Alzheimer’s disease when administered prophylactically; reduces increases in insoluble brain Aβ40 and Aβ42 levels in six-month-old mice when administered starting at five months of age; improves established spatial learning and memory deficits in the Morris water maze when compared with TgCRND8 control and non-transgenic littermate control mice; improves survival of TgCRND8 mice
Cayman Chemical MetaproterenolhemIsulfate 50mg
A long-acting β2-AR agonist with bronchodilator actions; inhibits TGF-α-induced hepatocyte DNA syntheses and proliferation in vitro (IC50 = 15 nM); dose-dependently relaxes lung strips and increases heart rate and inotropy of right atria and left atria, respectively, isolated from guinea pig (pD2s = 6.4, 7.08, and 6.61, respectively)
Cayman Chemical DaclatsvIr 100mg
An NS5A inhibitor (Kds = 8 and 210 nM for the NS5A33-202 and NS5A26-202 residues of HCV genotype 1b, respectively); potently inhibits HCV replication in multiple HCV replicon genotypes (EC50s = 9-146 pM) with the highest potency in genotypes 1b and 4a (EC50s = 9 and 12 pM, respectively); disrupts NS5A subcellular localization when used at a concentration of 1 nM; inhibits HCV RNA synthesis and virion assembly and secretion when used at a concentration of 1 nM; inhibits OAT1B1 and OAT1B3 (IC50s = 1.5 and 3.27 µM, respectively)
Cayman Chemical ChlorpyrIfos 50mg
An organophosphate insecticide; lethal to A. melinus, G. ashmeadi, E. eremicus, and E. formosa adults (LC50s = 0.8, 6, 12, and 17 ng/ml, respectively); induces mortality in O. insidiosus adults when applied to corn, sorghum, and alfalfa plants; toxic to mice (LD50 = 155 mg/kg); Postnatal day 11 to 14 exposure decreases nest building and defense behaviors in adult female mice at 3 mg/kg
Cayman Chemical AcamprosatecalcIum salt 100mg
An NMDA modulator with antagonist or agonist effects depending on brain region, receptor composition, and other factors; an acetylated derivative of homotaurine; decreases paired-pulse inhibition of GABAA IPSCs, indicating that it may inhibit GABAB autoreceptor-mediated inhibition of GABA release (300 µM); reduces voluntary intake of ethanol in rats (0.26 and 0.52 mmol/kg per day, i.p.)
Cayman Chemical nrIdronIc AcId 100mg
An amino bisphosphonate that inhibits FPP synthase (IC50 = 388.2 nM in a cell-free assay); reduces the number of RAW 264.7 cells expressing TRAP in an in vitro model of osteoclastogenesis induced by co-culture with CRL-12257 osteoblasts from 0.001-100 µM; inhibits FGF2-induced proliferation and tube formation in HUVECs at 30 µM; reduces the loss of trabeculae and increases bone density in the tibial metaphysis of growing rats at 0.1 mg/kg per day s.c.