Human Sera
Cayman Chemical SItaglIptInphosphate 50mg
A peptidomimetic inhibitor of FTase (IC50 500 pM) selective for FTase over GGTase I (IC50 50 nM) inhibits the growth of NIH3T3 cells expressing RasF at 20 UM reduces tumor growth in a mouse xenograft model using Calu-1 cells that contain a K-Ras oncogenic mutation
Cayman Chemical ACtylcImIgenol ArabInosID 50mg
An internal standard for the quantification of D-( )-glucose by GC- or LC-MS
Cayman Chemical AzImIlIdehydrochlorIde 50mg
An a-hydroxy acid that is over-produced in the human neurometabolic disease D-2-hydroxyglutaric aciduria may be synthesized from oxalate and propionyl-coenzyme A by an a-hydroxyglutaric acid synthetase in bacteria
Cayman Chemical ComplnatusIde 100mg
A monounsaturated fatty acid a major component of membrane phospholipids inhibits collagen-stimulated platelet aggregation at 10 Ug/ml inhibits fMLF-induced neutrophil aggregation and degranulation at 5 UM induces release of intracellular calcium in human platelets at 60 UM increases TNF-a IL-8 IL-6 and IL-1B production neutrophil accumulation and apoptotic and necrotic cell death in mouse lung
Cayman Chemical 4MethylpentnoIc AcIdd12 100mg
A positive allosteric modulator of a6B3Y2 subunit-containing GABAA receptors selectively increases GABA-induced currents in X laevis oocytes expressing a6B3Y2 over a1B3Y2 a2B3Y2 a3B3Y2 a4B3Y2 and a5B3Y2 subunit-containing receptors at 10 M
Cayman Chemical RucaparIbcamsylate 100mg
An internal standard for the quantification of pyrazolam by GC- or LC-MS intended for research and forensic applications
Cayman Chemical EscItalopramoxalate 50mg
A pan-Glut inhibitor inhibits glucose uptake in HEK293 cells expressing Glut1 Glut2 Glut3 or Glut4 (IC50s 2.6 8.8 4.5 and 0.9 UM respectively) and in A549 and H1299 NSCLC cells (IC50s 2.5 and 1.9 UM respectively) decreases the OCR in a time-dependent manner induces cell cycle arrest at the G1/S phase and increases ROS levels in A549 cells at 10 UM decreases tumor volume and weight in an A549 mouse xenograft model at 10 mg/kg
Cayman Chemical NMethylNnItrosopIperazIn 100mg
A succinamic acid-terminated PAMAM dendrimer ~59 Å in diameter has 128 surface groups inhibits plaque formation induced by MERS-CoV in Vero cells at 10 UM active against S. aureus PAMAM G5.0-SAH encapsulating doxorubicin decreases cell viability in KB carcinoma cells does not induce mortality in zebrafish at 250 ppm in tank water
Cayman Chemical 5-HydroxymethylcytIdIn 50mg
An analytical reference standard categorized as a lysergamide intended for research and forensic applications