Human Sera
Cayman Chemical N-NItrosonrnIcotIn 50mg
A heterobifunctional PEGylated linker contains a reactive NH2 end group as well as an azide functional group for use in click chemistry reactions has been used as a linker in the synthesis of bivalent mTOR inhibitors
Cayman Chemical Arnba euchroma Shkalkn 50mg
A peptide ETB receptor agonist selectively binds to ETB receptors (Ki 16 pM) over ETA receptors (IC50 1.9 UM) induces contractions of isolated guinea pig trachea from 0.01-1 UM reduces MAP in normotensive rats and SHRs and diminishes the transient depressor response in SHRs at 1 nmol/kg reduces infarct volume and improves motor and neurological function in a rat model of cerebral ischemia improves Ab-induced spatial memory deficits in a rat model of Alzheimers disease
Cayman Chemical NCbzGlyProGlyGlyProAla 50mg
An alkaloid with diverse biological activities inhibits 5-HT reuptake by OCT2 and dopamine reuptake by OCT3 (IC50s 0.137 and 0.354 UM respectively for human recombinant transporters) as well as reduces dopamine 5-HT and norepinephrine reuptake in mouse brain synaptosomes decreases immobility time in the forced swim test in a mouse model of depression induced by chronic unpredictable mild stress at 1.5 and 3 mg/kg reduces acetic acid-induced writhing in mice and increases the mechanical paw withdrawal threshold in a mouse model of bone cancer pain at 10 mg/kg
Cayman Chemical 5bromo4chLRo3Indolyl 50mg
A fluorogenic substrate for trypsin cathepsin B and cathepsin H AMC is released upon enzymatic cleavage by trypsin cathepsin B or cathepsin H and its fluorescence can be used to quantify trypsin cathepsin B and cathepsin H activity ex/em 340-360/440-460 nm respectively
Cayman Chemical HArgGlyAspCysOHtrIfluo 50mg
A platelet aggregation inhibitor inhibits ADP- collagen- or epinephrine-induced platelet aggregation in isolated human platelets (IC50s 730 92 and 3.4 UM respectively) inhibits arachidonic acid-induced platelet aggregation and TXA2 production in isolated rat platelets (IC50s 3.3 and 32.8 UM respectively) reduces LPS-induced contractions in isolated endothelium-denuded rat aortic strips in a concentration-dependent manner decreases thrombus weight in a rat model of arterio-venous shunt thrombosis at 50 mg/kg increases survival in a mouse model of septicemia induced by LPS at 10 and 20 mg/kg
Cayman Chemical Ocmum gratsmum Pprton 100mg
A modified form of AB42 that is citrullinated at arginine 5 exhibits increased transient formation of soluble oligomers and decreased rate of fibril formation compared with unmodified AB42 forms fibrils composed of parallelBsheets
Cayman Chemical MaduramIcInamonIum salt 100mg
A tricyclic antidepressant binds to the norepinephrine and 5-HT transporters (Kd 1.41 and 19.6 nM respectively) binds to histamine H1 muscarinic acetylcholine and a1-adrenergic receptors (Kds 25 25 and 130 nM respectively) inhibits norepinephrine uptake into rat whole brain and hypothalamic synaptosomes (IC50s 12 and 0.55 M respectively) and 5-HT uptake into rat whole brain synaptosomes (IC50 5.5 M) inhibits food-induced cataplexy in narcoleptic dogs at 1 mg/kg i.v.
Cayman Chemical TrImeprazIntartrate 100mg
An internal standard for the quantification of carebastine by GC- or LC-MS
Cayman Chemical 2Methyl2thIazolIn4carbo 100mg
An internal standard for the quantification of vapendavir by GC- or LC-MS
Cayman Chemical N-PropIonylglycIn 50mg
A coumarin with diverse biological activities inhibits LPS-induced nitric oxide production in mouse peritoneal macrophages (IC50 20 UM) completely inhibits collagen-induced aggregation of isolated rabbit platelets at 100 Ug/ml inhibits BChE (IC50 12.96 Ug/ml) reduces triacylglycerol levels and expression of the genes encoding SREBP-1c FASN and ACC1 in 3T3-L1 adipocytes and HepG2 cells
Cayman Chemical Mometason Furoate 50mg
A potent cell-permeable inhibitor of the tyrosine kinase activity of the epidermal growth factor (EGF) receptor (IC50 0 45 nM) effective in cells blocking tyrosine phosphorylation induced by either EGF or heregulin (IC50s 39 and 220 nM respectively)
Cayman Chemical TrIfluorothymIdIn 100mg
A muscarinic receptor agonist (EC50s 23 48 and 63 nM for M1 M3 and M5 respectively and 1 UM for M2 and M4) stimulates secretion by salivary glands and is useful in ameliorating xerostomia (dry mouth)
Cayman Chemical -NornIcotIn 100mg
A natural indole alkaloid with demonstrated beneficial effects in cancer obesity inflammation and many other conditions an AhR antagonist (Ki 28 nM) activator of TRPV1 (EC50 45 nM) and inhibitor of signaling through NF-KB
Cayman Chemical NIlvadIpIn 100mg
A JAK1 and JAK2 inhibitor (IC50s 0 0059 and 0 0057 UM respectively) selective for JAK1 and JAK2 over JAK3 TYK2 c-Met and Chk2 (IC50s 0 4 0 053 10 and 1 UM respectively) inhibits IL-6-induced phosphorylation of STAT3 in isolated human PBMCs and rat whole blood (IC50s 0 044 and 0 128 UM respectively) reduces disease severity in a type II collagen-induced mouse model of arthritis at 3 and 10 mg/kg decreases lung macrophage infiltration and disease severity in rhesus monkeys infected with SARS-CoV-2 at 4 mg/animal
Cayman Chemical TrospIumchlorIde 100mg
A cell-permeable asymmetrical indolocarbazole that exhibits antiproliferative activity by selectively blocking cyclin D1/Cdk4 (IC50 0 8 M) inhibits HCT116 and NCI-H460 tumor cell growth (IC50s 1 cell cycle arrest