Human Sera
Cayman Chemical 3 4trImethylenaPyrrolId 50mg
A cathinone whose physiological and toxicological properties are not known
Cayman Chemical MItoxntronhydrochlorIde 50mg
An inhibitor of DNA topoisomerase IIα and HIV-1 integrase (IC50s = 5.3 and 3.8 μM, respectively); intercalates DNA in a cell-free assay at 2 µM; inhibits DNA synthesis and induces DNA-protein crosslinks in vitro; inhibits the growth of K562 and K562-derived etoposide-resistant K/VP.5 cells (IC50s = 0.42 and 1.68 µM, respectively); inhibits HIV-1 integrase (IC50 = 3.8 μM); inhibits the membrane fusion of a mixed population of HEK293T cells expressing either ACE2 or the extracellular domain SARS-CoV-2 spike glycoprotein; inhibits the entry of SARS-CoV-2 into Vero E6 cells at 0.2 µM
Cayman Chemical PhentolamInmesylate 100mg
A reversible antagonist of α-adrenergic receptors, non-specifically binding all α1- and α2-adrenoceptors with nanomolar affinities; rapidly and transiently increases local blood flow
Cayman Chemical RufloxacInhydrochlorIde 100mg
A fluoroquinolone antibiotic; active against S. aureus, E. coli, P. aeruginosa, P. morganii, K. pneumoniae, and E. cloacae in vitro (MICs = 0.78, 0.78, 12.5, 1.56, M. luteus DNA gyrase (IC50 = 1.5 mM); inhibits DNA synthesis in S. aureus, E. coli, P. aeruginosa, K. pneumoniae, and E. cloacae (IC50s = 0.93, 1.03, 38.8, 0.55, and 0.66 μg/ml, respectively); reduces bacterial burden in the spleen and liver in a mouse model of systemic S. typhimurium infection at 50 mg/kg, p.o.
Cayman Chemical ArtIcaInhydrochlorIde 50mg
An amide local anesthetic most commonly used in dentistry; it possesses a unique ester side chain that is metabolized rapidly by circulating esterases
Cayman Chemical EvacetrapIb 100mg
A benzazepine-based inhibitor of CETP (IC50s = 5.5 and 26 nM for human recombinant and plasma-derived proteins, respectively); selective for CETP over a panel of cell surface and nuclear receptors at 1 µM; reduces expression of PCSK9 and LDLR in HepG2 cells in a dose-dependent manner; reduces protein levels of LDLR, SREBF2-M, and PCSK9 in HepG2 lysates, nuclear extracts, and culture medium, respectively, in a dose-dependent manner; inhibits CETP activity by 98.5, 98.6, and 18.4% at four, eight, and 24 h, respectively, in CETP/ApoA1 transgenic mice at 30 mg/kg; increases HDL cholesterol levels in serum from CETP/ApoA1 transgenic mice in a dose-dependent manner, including by 129.7% eight hours after a 30 mg/kg dose
Cayman Chemical ArachIdonyl SerInol 50mg
A 2-AG analog with increased stability; approximately a log less potent as a CB1 receptor agonist than 2-AG
Cayman Chemical PImonIdazole 100mg
A small molecule radiosensitizer that has proven to be an effective and nontoxic immunochemical hypoxia marker for human squamous cell carcinomas of the cervix, head and neck
Cayman Chemical FlupIrtInmaleate 100mg
An activator of Kv7/KCNQ; induces relaxation of preconstricted pulmonary arteries isolated from wild type and SERT+ mice; decreases mean right ventricular pressure and right ventricular hypertrophy in hypoxia-induced and SERT+ mouse models of pulmonary arterial hypertension at 30 mg/kg per day; increases the paw withdrawal threshold in a rat model of streptozotocin-induced diabetic neuropathy at 10 mg/kg; increases paw withdrawal latency in a rat model of carrageenan-induced paw inflammation when used in combination with morphine; indirectly antagonizes NMDA receptors via its effects on potassium channels
Cayman Chemical -nabasInhydrochlorIde 50mg
An alkaloid agonist of nAChRs with teratogenic activity; induces depolarization of TE 671 cells endogenously expressing human fetal muscle-type nAChRs (EC50 = 10.1 µM); binds to α4β2 subunit-containing nAChRs in K177 cells (Ki = 37.63 nM); teratogenic in vivo, inducing congenital defects, including cleft palate and severe fixed excessive flexure of carpal joints, in piglets when administered to pregnant dams during gestation days 43-53 at a dose of 2.6 mg/kg twice per day
Cayman Chemical CarotenoId MIxture 100mg
A mixture of carotenoids; contains capsanthin and β-carotene, as well as additional carotenoids and carotenoid esters
Cayman Chemical LOMEGUATRIB 50MG
A modified quanine base which acts as a pseudosubstrate inactivator of MGMT (IC50 = ~3 nM)
Cayman Chemical OctnoIc AcId-d15 100mg
An internal standard for the quantification of octanoic acid by GC- or LC-MS
Cayman Chemical Flumethason 50mg
An agonist of glucocorticoid and mineralocorticoid receptors (EC50s = 0.26 and 0.494 nM, respectively, in CV-1 cells expressing human receptors); inhibits the growth of UM-UC-3, TCC-SUP, and 5637 urothelial carcinoma cell lines (100 nM); decreases TNF production ex vivo in blood cells collected by BAL from calves with experimentally-induced local lung inflammation (5 mg per animal); impairs cell cycle re-entry of cardiac cells seven days post cryo-injury to the heart and impairs cardiac regeneration in vivo in zebrafish (5 μM)
Cayman Chemical 1R 3S3AmInocyclopentn c 50mg
A synthetic intermediate useful for pharmaceutical synthesis.